Presentation on theme: "Common Problems in Laboratory Animals Nirah H Shomer, DVM PhD Dip. ACLAM."— Presentation transcript:
Common Problems in Laboratory Animals Nirah H Shomer, DVM PhD Dip. ACLAM
Barbering Normal grooming behaviorNormal grooming behavior Usually, but not always, one unmarked barberUsually, but not always, one unmarked barber Barber is usually dominantBarber is usually dominant Usually harmless, but can precipitate conjunctivitis, ulcerative dermatitisUsually harmless, but can precipitate conjunctivitis, ulcerative dermatitis Barber
There is typically a dominant aggressive mouse Even if you remove the aggressor, another mouse may take his place.Even if you remove the aggressor, another mouse may take his place. Fights are almost exclusively between malesFights are almost exclusively between males In some strains, even littermates raised together will fight (BALB/c, SJL)In some strains, even littermates raised together will fight (BALB/c, SJL)
Fight wounds (fatal) Mice may die, rapidly, of septicemiaMice may die, rapidly, of septicemia Treat with broad spectrum antibioticsTreat with broad spectrum antibiotics
Skin lesions EtiologyPatternTreatment EtiologyPatternTreatment Barbering Normal groomingany (same all mice)remove barber Fight Wounds Fightingtail, back, genitalsremove aggressor Ulcerative Dermatitis Unknownnape of neck, none under armsointments pain drugs Linked to C57BL2° infection commonantibiotics Linked to C57BL2° infection commonantibiotics
Emaciation Look for underlying causeLook for underlying cause Report objectively using Body Condition ScoreReport objectively using Body Condition Score
These are littermates. What is the mouse on the right? Runt What should you check for?
Malocclusion Rodent incisors grow continuouslyRodent incisors grow continuously Can be maintained by weekly clippingCan be maintained by weekly clipping
Malocclusion is heritable
Diarrhea Mouse diarrhea is usually very subtleMouse diarrhea is usually very subtle All you see is bedding stuck to pellets and anusAll you see is bedding stuck to pellets and anus
Rabbit feces Normal pellets Diarrhea True or False: diarrhea is normal in rabbits False: they do have “night feces”, cecotrophs, which are usually eaten directly from the anus
Porphyrin staining Pigment comes from Harderian glandsPigment comes from Harderian glands Increased in stress, respiratory disease, sialodacryoadenitis virus (SDA) infectionIncreased in stress, respiratory disease, sialodacryoadenitis virus (SDA) infection Prominent in rats and gerbils, not in miceProminent in rats and gerbils, not in mice Found around eyes, nares, paws (from grooming face)Found around eyes, nares, paws (from grooming face)
Conjunctivitis Inflammation of the conjunctival tissues; aka pink-eye. Usually bacterial, may not respond well to antibiotics.
Proptosis Bulging or protruding eyeBulging or protruding eye Causes include tumor, abscess, retroorbital bleed/hematoma, glaucomaCauses include tumor, abscess, retroorbital bleed/hematoma, glaucoma Secondary effects include keratitis, loss of eyeSecondary effects include keratitis, loss of eye