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TAO1 kinase maintains chromosomal stability by facilitating proper congression of chromosomes by Roshan L. Shrestha, Naoka Tamura, Anna Fries, Nicolas.

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Presentation on theme: "TAO1 kinase maintains chromosomal stability by facilitating proper congression of chromosomes by Roshan L. Shrestha, Naoka Tamura, Anna Fries, Nicolas."— Presentation transcript:

1 TAO1 kinase maintains chromosomal stability by facilitating proper congression of chromosomes by Roshan L. Shrestha, Naoka Tamura, Anna Fries, Nicolas Levin, Joanna Clark, and Viji M. Draviam Open Biology Volume 4(6): June 4, 2014 ©2014 by The Royal Society

2 TAO1-depleted cells display chromosome congression defects. Roshan L. Shrestha et al. Open Biol. 2014;4: ©2014 by The Royal Society

3 Rescue of TAO1 depletion-induced chromosome congression defects. Roshan L. Shrestha et al. Open Biol. 2014;4: ©2014 by The Royal Society

4 TAO1 is required to maintain dynamic microtubules during mitosis. Roshan L. Shrestha et al. Open Biol. 2014;4: ©2014 by The Royal Society

5 TAO1-depleted cells display mis-segregating lagging chromosomes. Roshan L. Shrestha et al. Open Biol. 2014;4: ©2014 by The Royal Society

6 Taxol or MPS1 inhibitor treatments in TAO1-depleted cells. Roshan L. Shrestha et al. Open Biol. 2014;4: ©2014 by The Royal Society

7 Correcting erroneous kinetochore–microtubule attachments requires TAO1. Roshan L. Shrestha et al. Open Biol. 2014;4: ©2014 by The Royal Society

8 Model of TAO1 depletion-induced mis-segregation arising from defective microtubule stability. Roshan L. Shrestha et al. Open Biol. 2014;4: ©2014 by The Royal Society


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