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-HA -HB -Factor XI deficiency -Factor II deficiency -Factor V deficiency -Factor XIII deficiency -Factor VII deficiency Dental problems in Hemophilia
-Severe Deficiency (Less than 1%) -Moderate Deficiency (less than 1%) -Moderate Deficiency (1%-5%) -Mild Deficiency (≥ 5%) Precoagolant classification
-Frequent bleeding -Two or four per month -Common sites (Joint, muscle, skin) -Hemarthrosis -Chronic muscular problems -Debilitating painful arthritis -Knee, elbow, ankle, Hip, shoulder -Pseudotumor in jaw -Mouth laceration Severe deficiency Hemophilia
Hemophilia Infrequently bleeding Only surgery or Trauma
Purified concentration factor Factor through recombinant technology Whole blood, plasma, cryoprecipitate Half life factor VIII, IX Medical Treatment of Hemophilia
(…Continue) Factor VIII concentrate Routine bleeding (40%) Mild VIII Deficiency DDAVP DDAVP Rise of factor VIII Activity/VWF Tachyphylaxis Water Retention Hyponautremia Seizures
Factor IX deficiency Purified coagulation factor IX concentrate Pure production class protrombine complex PCC = factor IX + … Repeated PCC Infusion DIC Level factor (40%) Hemophilia B Treatment
Vonwillbrand disease Subtyping VWF DDAVP (VWF) Other modalities
Inhibitors(28% HA, 3% - 5% )in Severe HB Low Response Rate to factors Continue Hemorrhage Arthritis Degenerative joint disease Viral Infection blood borne Infection AIDS, Hepatitis B,C Complications factor Infusion
Risks to dental staff Acquiring hepatitis B,C Acquiring HIV
Development of a treatment plan in the hemophilia Use of anti fibrinolytics,Dosage Side effect
Pain control in Hemophilia (…Continue) Analgesia Local Anesthesia PDL Injection Infiltration Block Anesthesia
Prevention of Dental Disease Periodontal therapy Restorative procedures Pulp therapy Oral surgery Surgical complications Antibiotic prophylaxis Orthodontic treatment Dental Healthcare protocol in hemophilia
The end Dr. Jabbarifar 2007
Fungal Infection Viral Infection Bacterial Infection Neoplasm's Idiopathic lesions HIV-gingivitis, HIV – Periodontitis. Oral manifestations HIV Infection
The end Dr. Jabbarifar 2007
Hemophilia What is Hemophilia? Hemophilia is an inherited bleeding disorder in which there is a deficiency or lack of factor VIII or factor IX clotting.
1. Normal haemostasis Haemostasis is the process whereby haemorrhage following vascular injury is arrested. It depends on closely linked interaction.
Hemophilia Definition: rare bleeding disorders due to inherited deficiencies in co-agulation factors Types: 1. Haemophilia A (Classic) Factor VIII.
The hemophilias A and B X-linked hereditary blood clotting disorders due to deficiency of factor VIII (hemophilia A) or factor IX (hemophilia B) Identical.
MLAB 1227: Coagulation Keri Brophy-Martinez
Initiation substances activate s by proteolysis a cascade of circulating precursor proteins which leads to the generation of thrombin which in turn converts.
MISHA MAZHAR 2k10-NUST-BS-V&I-54. Mutations in F8 or F9 genes. Leads to lack of proteins made by these genes. F8 responsible for making the blood.
By: Brandon Jamison, Tucker Dodson, Nami Small. There are several conditions can cause elbow pain and disability, and lead patients and their doctors.
Faculty of Allied Medical Science
Von Willebrand’s Disease. vWD Family of bleeding disorders Family of bleeding disorders Caused by a deficiency or an abnormality of von Willebrand Factor.
HEMOPHILIA By: Jess Gardner and Claire Griffin.
Factor VII Deficiency Diagnosis and Management
Haemostasis describes the normal process of blood clotting. It takes place via a series of complex, tightly regulated interactions involving cellular.
Hemophilia U & I Inc., USA Payor Education Presentation Last Updated; January, 2012.
Cristy M. Thomas FNP-BC University of Nevada School of Medicine University Medical Center, Las Vegas NV Nevada’s Only Level 1 Adult Trauma, Level 2 Pediatric.
Presenter: Dr Suzanna Mwanza Moderator: Dr Sambo
The Basics of Hemophilia. Hemostatic System Blood vessels Platelets Plasma coagulation system Proteolytic or Fibrinolytic system.
Hematology Blueprint PANCE Blueprint. Coagulation Disorders.
Bleeding and Kristine Krafts, M.D. Thrombotic Disorders.
FVIII PRODUCT USAGE IN CLINICAL SETTINGS TSEAC October 31, 2005 Mark Weinstein, Ph.D. Office of Blood Research and Review CBER, FDA.
Hemophilia A By Marissa Miuccio.
The Basics of Hemophilia
The Basics of Hemophilia Nursing Working Group National Hemophilia Foundation.
Sarah Moreno Ms.Brown Child dev. -6
February 4 th, The Child With Pain Single Joint Involvement Multiple Joint Involvement With Fever Septic arthritis/Osteomyelitis Sympathetic arthritis.
Inherited bleeding disorder of primary hemostasis.
ORGAN TRANSPLANTATION: PERSONS WITH CLOTTING DISORDERS Margaret Ragni, MD University of Pittsburgh.
Bleeding Disorders Dr. Farjah H.AlGahtani
Profile and competency for dentist Profiles Competencies.
BLEEDING DISORDERS AN OVERVIEW WITH EMPHASIS ON EMERGENCIES.
An Introduction to Haemophilia and related bleeding disorders M QARI, MD, FRCPA.
Abnormal bleeding in children J Kiwanuka. GENERAL INTRODUCTION.
Bleeding and coagulation disorders
Scene II: Will Alan ever play for the Lakers? After this lesson, the students will be able to: 1)Explain x-linked inheritance using Factor VIII deficiency.
Hemophilia and Rare Bleeding Disorders
MTP Octaplex rFVIIa Calgary. Massive Transfusion Protocol.
بسم الله الرحمن الرحیم.
Bleeding Disorders JANUARY 19, 2012 Erin M. Kwolek.
The Hemophilia Federation of America (HFA) is a national nonprofit organization that assists and advocates for the bleeding disorders community. MISSION.
Chapter 23. Bleeding disorders associated with coagulopathy O bleeding platelet count, bleeding time, capillary fragility test: normal PT, aPTT: prolonged.
Role of Factor Concentrates in Perioperative Coagulopathies Dr Neville Gibbs Department of Anaesthesia Sir Charles Gairdner Hospital.
Child with hematological dysfunction Emad Al Khatib, RN,MSN,CNS.
By: Bekim Ameti. Information On Hemophilia Hemophilia is the oldest known heredity bleeding disorder. Hemophilia has been known for thousands of years.
Hemophilia B. World Federation of Hemophilia Global Survey 2008 Demographics Number of countries in this survey: 108 Percentage of world population covered.
Obada Al-Eisa Saud Bashtawy Emad Mansour. It is an acquired condition characterized by massive activation of the coagulation system. It is always.
Hemophilia A By Saad Mukaty. Definition of Hemophilia Hemophilia (A) is a rare disorder in which blood doesn’t clot normally because it lacks important.
By Dr. Ahmed Mostafa Assist. Prof. of anesthesia & I.C.U.
Hemophilia By Charlene Yan.
Factor II Deficiency By Jessica Johnson Medical Terminology II December 2, 2004.
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