Presentation is loading. Please wait.

Presentation is loading. Please wait.

Flucoral ® Pharmacological Composition Each capsule containing 150mg Fluconazole. Fluconazole is a broad spectrum Systemic Antifungal.

Similar presentations


Presentation on theme: "Flucoral ® Pharmacological Composition Each capsule containing 150mg Fluconazole. Fluconazole is a broad spectrum Systemic Antifungal."— Presentation transcript:

1

2 Flucoral ® Pharmacological Composition Each capsule containing 150mg Fluconazole. Fluconazole is a broad spectrum Systemic Antifungal

3 Flucoral ® Mechanism of action Inhibition of cytochrome P-450 → Impairment of Ergosterol synthesis in the fungal cell membrane → Interfers with fungal cell membrane function &growth → stop the fungal growth N.B: Fluconazole is highly selective inhibitor to fungal cytochrome P-450 and doesn't affect on liver cytochrome P-450

4 Flucoral ® Pharmacokinetics  The bioavailability of orally administered Fluconazole is over 90%  Absorption of fluconazole is unaffected by food or gastric acidity Pharmacokinetics  The bioavailability of orally administered Fluconazole is over 90%  Absorption of fluconazole is unaffected by food or gastric acidity

5 Flucoral ® Pharmacokinetics Peak plasma concentrations (C-max) occur between 1 and 2 hours with a terminal plasma elimination half-life of approximately 30 hours after oral administration

6 Flucoral ® Pharmacokinetics Fluconazole lipophillicity will achieve tissue levels exceeding the required MICs for all pathognomonic fungi for a complete week.

7 Effective Against Candida Species Infection At Wide Range Of Body Sites And Tissues.

8

9

10 Flucoral ® Pharmacokinetics Fluconazole(FLUCORAL) is cleared primarily by renal excretion, with approximately 80% of the administered dose appearing in the urine as unchanged drug. About 11% of the dose is excreted in the urine as metabolites.

11 Flucoral ® Excellent Eradication Flucoral is well established as a first line management option for the treatment of localized and systemic C.albicans infections. Micheal V. Martin;Journal of Antimicrobial Chemotherapy (1999)

12 Pityriasis Versicolor

13 Flucoral ® Excellent eradication rates in PityriasisVersicolor Single dose fluconazole Vs Itraconazole

14 Onychomycosis

15 Flucoral ® Excellent eradication rates in Onychomycosis

16 Flucoral ®

17

18 Flucoral penetrates the nails and persists after twice weekly doses for 6 months in toenails and fingernails Amalia del Palacio et al,dermatophytosis treatment (2000).Madrid,Spain

19  Indications: 1: tinea Capitis. 2: Tinea cruris

20 Tinea Barbe. Tinea Corporis.

21 Tinea Pedis. Tinea Versicolor.

22 Onychomycosi s. Candidiasis.

23 Flucoral ® Safety Fluconazole is contraindicated in lactating women and category C in pregnant women.

24 Flucoral ® Monitoring of liver enzymes is not recommended during therapy with fluconazole (FLUCORAL) American Family Physician,February 15,2001;Volume 63,Number 4

25 Flucoral ® Itraconazole is not suitable for the routine treatment of infections in patients with raised liver enzymes,history of liver diseases when treatment prolonged (>1 month) liver enzyme monitoring should be undertaken Journal of antimicrobial chemotherapy.1999

26 Flucoral ® Flucoral is available as a box containing 2 capsules each containing Fluconazole 150mg with a price of LE.

27 Thank You


Download ppt "Flucoral ® Pharmacological Composition Each capsule containing 150mg Fluconazole. Fluconazole is a broad spectrum Systemic Antifungal."

Similar presentations


Ads by Google