Presentation on theme: "Flucoral® Pharmacological Composition Each capsule containing 150mg Fluconazole. Fluconazole is a broad spectrum Systemic Antifungal."— Presentation transcript:
1Flucoral®Pharmacological Composition Each capsule containing 150mg Fluconazole. Fluconazole is a broad spectrum Systemic Antifungal
2Flucoral®Mechanism of action Inhibition of cytochrome P-450→Impairment of Ergosterol synthesis in the fungal cell membrane→Interfers with fungal cell membrane function &growth→stop the fungal growth N.B: Fluconazole is highly selective inhibitor to fungal cytochrome P-450 and doesn't affect on liver cytochrome P-450
3Flucoral®PharmacokineticsThe bioavailability of orally administered Fluconazole is over 90%Absorption of fluconazole is unaffected by food or gastric acidity
4Flucoral® Pharmacokinetics Peak plasma concentrations (C-max) occur between 1 and 2 hours with a terminal plasma elimination half-life of approximately 30 hours after oral administration
5Flucoral®Pharmacokinetics Fluconazole lipophillicity will achieve tissue levels exceeding the required MICs for all pathognomonic fungi for a complete week.
6FlucoralEffective Against Candida Species Infection At Wide Range Of Body Sites And Tissues.
9Flucoral® Pharmacokinetics Fluconazole(FLUCORAL) is cleared primarily by renal excretion, with approximately 80% of the administered dose appearing in the urine as unchanged drug. About 11% of the dose is excreted in the urine as metabolites.
10Excellent Eradication Flucoral®Excellent EradicationFlucoral is well established as a first line management option for the treatment of localized and systemic C.albicans infections.Micheal V. Martin;Journal of Antimicrobial Chemotherapy (1999)
22Flucoral®SafetyFluconazole is contraindicated in lactating women and category C in pregnant women.
23American Family Physician,February 15,2001;Volume 63,Number 4 Flucoral®Monitoring of liver enzymes is not recommended during therapy with fluconazole (FLUCORAL)American Family Physician,February 15,2001;Volume 63,Number 4
24Journal of antimicrobial chemotherapy.1999 Flucoral®Itraconazole is not suitable for the routine treatment of infections in patients with raised liver enzymes,history of liver diseases when treatment prolonged (>1 month) liver enzyme monitoring should be undertakenJournal of antimicrobial chemotherapy.1999
25Flucoral®Flucoral is available as a box containing 2 capsules each containing Fluconazole 150mg with a price of LE.