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Spontaneous Damage to DNA. Examples of DNA Damage Induced by Radiation and Chemicals.

Published byEsmeralda Rapson Modified over 9 years ago

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Presentation on theme: "Spontaneous Damage to DNA. Examples of DNA Damage Induced by Radiation and Chemicals."— Presentation transcript:

1 Spontaneous Damage to DNA

2 Examples of DNA Damage Induced by Radiation and Chemicals

3

4

5 Direct Repair of Thymine Dimers Not in humans

6 A metiltransferase é gasta nesta reacção

7 Base-Excision Repair

8 Nucleotide-Excision Repair of Thymine Dimers

9 Xeroderma pigmentosum Autosomal recessive mutations in several complementation groups Extreme sensitivity to sunlight Predisposition to skin cancer (mean age of skin cancer = 8 yrs vs. 60 for normal population)

10 Nucleotide excision repair - Energéticamente ineficiente

11 Mismatch Repair in E. coli

12

13 Teste de Ames para agentes mutagenicos

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