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Spontaneous Damage to DNA
Examples of DNA Damage Induced by Radiation and Chemicals
Direct Repair of Thymine Dimers Not in humans
A metiltransferase é gasta nesta reacção
Nucleotide-Excision Repair of Thymine Dimers
Xeroderma pigmentosum Autosomal recessive mutations in several complementation groups Extreme sensitivity to sunlight Predisposition to skin cancer (mean age of skin cancer = 8 yrs vs. 60 for normal population)
Nucleotide excision repair - Energéticamente ineficiente
Mismatch Repair in E. coli
Teste de Ames para agentes mutagenicos
Control of skin cancer by the circadian rhythm Background presented by Nathalie Javidi-Sharifi Druker Lab.
DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS.
DNA Mutations and Repair Chapter 17. Mutation: is defined as an inherited change in genetic information by cell division or individual organisms. Chernobyl,
8.5 DNA Repair At the end of S phase, DNA polymerase has copied both strands of template DNA DNA polymerase does make mistakes -1 mistake every 10,000.
Dr.Aida Fadhel Biawi 2014 Mechanisms of DNA repair.
Microbial Genetics (Micr340) Lecture 14 DNA Repair and Mutagenesis.
12.6 DNA Repair. DNA Repair Errors in DNA replication or damage to DNA create mutations Errors in DNA replication or damage to DNA create mutations -
Jordan A. Mays. Key Points: 8 XP family proteins repair DNA damaged by sunlight through Nucleotide Excision Repair. XPF-ERCC1 complex is a structure-specific.
XERODERMA PIGMENTOSUM XPF and Nucleotide Excision Repair Sapna Patel
The Mutability and Repair of DNA REPLICATION ERRRORS AND THEIR REPAIR The nature of mutations TransitionsTransversions.
11.1DNA Is Reproduced by Semiconservative Replication.
22 September, 2006 Chapter 9 Mutation and Repair.
Gene Mutations. Mutation Vocabulary Gene Mutation Point Mutation – Substitution – Silent – Missense – Nonsense Frameshift – Insertion – Deletion Chromosomal.
Copyright © 2009 Pearson Education, Inc. Art and Photos in PowerPoint ® Concepts of Genetics Ninth Edition Klug, Cummings, Spencer, Palladino Chapter 16.
Depurination Release of adenine or guanine bases.
William S. Klug Michael R. Cummings Charlotte A. Spencer Concepts of Genetics Eighth Edition Chapter 15 Gene Mutation, DNA Repair, and Transposition Copyright.
Maintenance of genomes Correcting replication errors Repairing DNA damage.
Aim :How are the mistakes that occur during DNA replication repaired?
Chapter 20 DNA Replication and Repair. Replication is bidirectional.
GENETICS ESSENTIALS Concepts and Connections SECOND EDITION GENETICS ESSENTIALS Concepts and Connections SECOND EDITION Benjamin A. Pierce © 2013 W. H.
Gene Mutation. Mutation Mutation: change in DNA sequence Causes of mutation: Spontaneous Due to naturally- occurring errors in DNA replication Induced.
DNA Repair Uracil-DNA Glycosylase. DNA is continually assaulted by damaging agents (oxygen free radicals, ultraviolet light, toxic chemicals). Fortunately,
DNA repair. spontaneous vs. induced mutation gametic vs. somatic mutation lethal or conditional mutation Classification of the mutation.
DNA Repair DNA repair is a system used to correct DNA damage caused by either: 1-Errors during DNA replication including incorrect base-pairing (mismatching)
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Translation mRNA is translated in codons (three nucleotides) Translation.
Various ways in which DNA damage leads to mutations in proteins Insertion.
Exposure to UV light Thymine dimer No replicating DNA strand.
Mutations in Replication What did you learn in your reading? Who performs mismatch repair? Why does DNA constantly have to be maintained? What.
Copyright © 2009 Pearson Education, Inc. Chapter 15 Lecture Concepts of Genetics Tenth Edition Gene Mutation, DNA Repair, and Transposition.
DNA REPAIR. DNA is the only biological molecule that is repaired DNA damage Alteration to the chemical structure of DNA Mutation Change in the sequence.
If you haven’t done so already, REGISTER TO VOTE! You live in a free country; make your voice heard! This website will take you through the process to.
The Mutability and Repair of DNA. 1. Switch of one base for another: purine pyrimidine (transition) (transversion) 2. insertion or deletion of a nucleotide.
Mutations. Learning Objectives By the end of this class you should understand: The pedigree of a spontaneous mutation The concept of mutation rates and.
Cancer Cell cycle, oncogenes and tumour suppressors Jake Turner.
DNA Repair DNA repair is a system used to correct DNA damage caused by either: A- Errors during DNA replication including incorrect base-pairing (mismatching.
Xeroderma Pigmentosum, XPF and Nucleotide Excision Repair By Crystal Stanford.
Gene Mutation *Mutation Chromosome mutations/aberrations Classification of Mutations 1. Spontaneous vs. Induced Spontaneous mutation Induced mutation 2.
Genetic Material-DNA 6 November 2003 Reading:The Cell; Chapter 5, pages:
Mutations. Sickle Cell Anemia Mutations Can be a change in the DNA base sequence or a change in a chromosome Can be a change in the DNA base sequence.
Xeroderma Pigmentosum(XP) 着色性干皮病. We owe our lives to light from the sun,which provides the energy captured during photosynthesis ( 光合作用 ). But the sun.
Xeroderma Pigmentosum (XPF) Cara Mitchell. Characteristics of XP Extreme photosensitivity Early onset of skin cancers Blistering of skin from sun.
Gene and Chromosomal Mutations. What is a mutation? Mutations are changes made to an organism’s genetic material. These changes may be due to errors in.
Lecture 18 DNA Repair Rohini. K. Learning Objective 08 Nov 2011Rohini K FoM 2 An overview of the types of DNA damage DNA repair mechanisms Defects.
Mutations Chapter Twelve. What is a Mutation? Change in DNA’s nucleotide sequence 1.Specific base changes –Molecular level 2.Chromosomal rearrangement.
Today’s Agenda: 1. A Microarray Primer 2. Guest Speaker: Dr. Michael Schlador 3. Follow-up: the Use of Microarray Analysis in Chemotherapeutics 4. Preview.
Lecture 3.Mutations and DNA Reparation Myandina Galina Ivanovna professor, Ph.D.,Dr.Sc.
About XP Xeroderma pigmentosum was first described in 1874 by Hebra and Kaposi. In 1882, Kaposi coined the term xeroderma pigmentosum for the condition,
1 Mutations Mutations are inheritable changes in the DNA –“Failure to faithfully store genetic information” Changes can be to chromosomes or genes –Current.
DNA Repair Nucleotide Excision Repair XP and CS BiS222 By Jooyoung Chang 장주영 Class #01 / Stu. #
Regulation of Bacterial Gene Expression Constitutive enzymes are expressed at a fixed rate. Other enzymes are expressed only as needed. –Repressible enzymes.
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