1. SELAGINELLA DEODERLEINII AS ANTI CANCER Created By : ANIK SETYANI (G84120002)

2. SELAGINELLA DEODERLEINII Definition Bioactive compuond Anti cancer

3. Selaginella is a potent medicinal-stuff, which contains diverse of natural products such as alkaloid, phenolic (flavonoid), and terpenoid. Continuue

4. Selaginella is traditionally treated to cure several disease depending on species, such as cancer or tumor (uterus, nasopharyngeal, lung, etc), wound, after childbirth,menstrual disorder, female reproduction disease, expulsion of the placenta, tonic (for after childbirth, increase bodyendurance, anti ageing, etc). ETC KLICK IN HERE

5. SELAGINELLA DEODERLEINII Divisi : Pteridophyta Kelas : Lycopodiinae Bangsa : Selaginellales Suku : Selaginellaceae Marga : Selaginella Jenis : Selaginella deoderleinii Hieron Manfaat : menghilangkan panas dan lembab, melancarkan aliran darah, antitoksik, antineoplasma, penghenti pendarahan (hemostatis) dan menghilangkan bengkak, mengatasi batuk, infeksi saluran nafas, radang paru, hepatitis, diare, keputihan, tulang patah, pendarahan dan kanker.

6. SELAGINELLA DEODERLEINII S. doederleinii is usually treated as anti cancer, but also acts as antiviral and anti-inflammatory. Water extract of S. doederleinii has antimutagenic against both picrolonic acid- and benzo[α]pyrene-induced mutation to cancer cell Ethanolic extract of S. doederleinii that is amentoflavone and heveaflavone has cytotoxic activity against cancer cell of murine L 929. Extract of S. doederleinii also has cytotoxic against the three human cancer cell lines, HCT, NCI-H358, and K562 (Lee et al. 2008)

7. BIOACTIVE COMPOUND S. doederleinii contains : amentoflavone, 2',8''-biapigenin, delicaflavone, ginkgetin, heveaflavone, hinokiflavone, isocryptomerin, kayaflavone, ochnaflavone, podocarpusflavon, A, robustaflavone, sumaflavone, and taiwaniaflavone.

8. SELAGINELLA DEODERLEINII amentoflavone heveaflavone Anti cancer

9. AMENTOFLAVONE Amentoflavone, the most common biflavonoid of Selaginella, has various biological and pharmacological effects, including antioxidant, anti cancer, anti-inflammatory antimicrobial, antivirus. such as influenza (A, B), hepatitis (B), human immunodeficiency virus (HIV-1), herpes (HSV-1, HSV-2), herpes zoster (VZV), measles,respiratory syncytial Virus, anti-urcerogenic, Anxiolytic, analgesic and anti-angiogenesis agent.

10. HEVEAFLAVONE Heveaflavone has cytotoxic activity against cancer cell of murine L 929 (Lin et al1994)

11. REFERENCES SETYAWAN A D. 2011. NATURAL PRODUCTS FROM GENUS SELAGINELLA (SELAGINELLACEAE). JURNAL NUSANTARA BIOSCIENCE. 3 (1) : 44-58.