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1) Mackenzie et all 2011*2) Mackenzie et al 2006*3) Sampathy et al 2006*4) Cairns et al 2007* Brain region Frontal cortexBrain regionFrontal cortex and.

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Presentation on theme: "1) Mackenzie et all 2011*2) Mackenzie et al 2006*3) Sampathy et al 2006*4) Cairns et al 2007* Brain region Frontal cortexBrain regionFrontal cortex and."— Presentation transcript:

1 1) Mackenzie et all 2011*2) Mackenzie et al 2006*3) Sampathy et al 2006*4) Cairns et al 2007* Brain region Frontal cortexBrain regionFrontal cortex and dentate gyrus of the hippocampusBrain region Frontal cortexBrain region Frontal cortex Staining Ubiquitin-immunohistochemistry TypeThe main characteristicsType The main characteristicsTypeThe main characteristicsTypeThe main characteristics Type A main distributionpredominantly layer II Type 1 Cortex layer II NCIsmoderate or numerous Type 3 main distributionsuperficial cortical layer Type 3 main distributionsuperficial NCIsmany NTsmoderate or numerous NCIsabundance ring shapedNCIsnumerous NIIsoccasional to some DNsmany shortNTsabundance shortDNsnumerous DG, granule cells NCIsfew to manyDotsin the gray matterNIIsvariable NIIsoccasional Type B main distributionall layers Type 3a Cortex layer II NCIsmoderate or numerous Type 2 main distributionsuperficial and deep Type 2 main distributionsuperficial and deep NCIsmoderateNTsfew or noNCIspredominantlyNCIsnumerous DNsfewAll layer’sNIIsnoNTsrareDNsinfrequent DG, granule cellsNCssometimes numerous NIIssparse to no Type 3b Cortex layer II NCIsrelatively few or no NTsrelatively few or no DG, granule cellsNCIsmajor pathology Type C main distributionpredominantly layer II Type 2 Cortex layer II NCIsfew or no Type 1 main distributionsuperficial cortical layer Type 1 main distributionsuperficial and deep NCIsfew NTs-predominant or exclusivelyNCIsoccasional to someNCIsfew to rare NIIs-noNTsabundance, longDNsabundance, long DNsmany long DG, granule cellsNCIs-none to numerous NIIsfew or no Type D main distributionall layers Type 4 main distributioncortex NCIsfewNCIsinfrequent DNsmany shortDNsinfrequent NIIsmany lentiformNIIsnumerous * Information in the table from original publications. 1) current nomenclature 2-4) implemented here. NCI - intreneuronal inclusion, NII - neuronal intranuclear inclusion, NT - neurite, DN - dystrophic neurite Supplement Figure 1. Instructions for the assessment of FTLD-TDP related pathology in subjects with FTD seen in ubiquitin, p62, TDP43 or phopshorylated TDP43/IHC ASSESSMENT of immunoreactive (IR) lesions For each assessable and identified region, state yes/no or give your estimate: 0/none 1/occasional - have to be looked for 2/moderate- easily seen 3/numerous - overwhelming 1) The assessable region is identified in the section:(yes/no) 2) Pathological IR structures (including labeled dots, inclusions and neurites) are seen: (yes/no) 3) IR dots are seen (see Sampathu et al., 2006): (yes/no) 4) IR thin and short neurites are seen: (yes/no) 5) Give your estimate of extent of the lesion above: (0-3) 6) IR long and tortuous neurites are seen: (yes/no) 7) Give your estimate of extent of the lesion above: (0-3) 8) IR cytoplasmic inclusions are seen: (yes/no) 9) Give your estimate of extent of the lesion above: (0-3) 10) IR ring-shaped cytoplasmic inclusions are seen: (yes/no) 11) Give your estimate of extent of the lesion above: (0-3). 12) IR intranuclear inclusions are seen: (yes/no)


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