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The immunoglobulin-like genetic predetermination of the brain: the protocadherins, blueprint of the neuronal network Naturwissenschaften (2001) N. Hilschmann,

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Presentation on theme: "The immunoglobulin-like genetic predetermination of the brain: the protocadherins, blueprint of the neuronal network Naturwissenschaften (2001) N. Hilschmann,"— Presentation transcript:

1 The immunoglobulin-like genetic predetermination of the brain: the protocadherins, blueprint of the neuronal network Naturwissenschaften (2001) N. Hilschmann, H.U. Barnikol et al. Review Article th MPL Lab. Seminar A-Ram Jeong

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6 The Structure and function of protocadherins. Protocadherins are cell- adhesion molecules. Their morphogenetic capacity is accomplished by their bipartite structure, which is very similar to that of classical cadherins. Besides a transmembraneous section they have an N-terminal extracellular part consisting of six domains and a C-terminal intracellular domain.

7 The protocadherin genes. We distinguish three classes of protocadherins: alpha, beta and gamma. In the genome there are three serially repeated V-gene sets, each followed by corresponding C-genes.

8 Immunoglobulin gene translocation and expression

9 Protocadherin gene translocation and expression

10 The module system of the neuronal network

11 References 1. Recent progress in protocadherin research Experimental Cell Research 261, (2000) 2. Phylogenetic analysis of the cadherin superfamily allows identification J. Mol. Biol. (2000) 299, Protocadherins and diversity of the cadherin superfamily Journal of Cell Science 109, (1996) 4. Cadherin superfamily genes: functions, genomic organization, and neurologic Diversity GENES & DEVELOPMENT 14:1169–1180 (2000)


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