Presentation on theme: "The immunoglobulin-like genetic predetermination of the brain: the protocadherins, blueprint of the neuronal network Naturwissenschaften (2001) N. Hilschmann,"— Presentation transcript:
The immunoglobulin-like genetic predetermination of the brain: the protocadherins, blueprint of the neuronal network Naturwissenschaften (2001) N. Hilschmann, H.U. Barnikol et al. Review Article 2002. 1. 14. 25th MPL Lab. Seminar A-Ram Jeong
The Structure and function of protocadherins. Protocadherins are cell- adhesion molecules. Their morphogenetic capacity is accomplished by their bipartite structure, which is very similar to that of classical cadherins. Besides a transmembraneous section they have an N-terminal extracellular part consisting of six domains and a C-terminal intracellular domain.
The protocadherin genes. We distinguish three classes of protocadherins: alpha, beta and gamma. In the genome there are three serially repeated V-gene sets, each followed by corresponding C-genes.
Immunoglobulin gene translocation and expression
References 1. Recent progress in protocadherin research Experimental Cell Research 261, 13-18 (2000) 2. Phylogenetic analysis of the cadherin superfamily allows identification J. Mol. Biol. (2000) 299, 551-572 3. Protocadherins and diversity of the cadherin superfamily Journal of Cell Science 109, 2609-2611 (1996) 4. Cadherin superfamily genes: functions, genomic organization, and neurologic Diversity GENES & DEVELOPMENT 14:1169–1180 (2000)