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Groningen Bioinformatics Centre Ritsert Jansen, Rainer Breitling M. Tauqeer Alam, Rudi Alberts, Martijn Dijkstra, Jingyuan Fu,Tejas.

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Presentation on theme: "Groningen Bioinformatics Centre Ritsert Jansen, Rainer Breitling M. Tauqeer Alam, Rudi Alberts, Martijn Dijkstra, Jingyuan Fu,Tejas."— Presentation transcript:

1 Groningen Bioinformatics Centre Ritsert Jansen, Rainer Breitling M. Tauqeer Alam, Rudi Alberts, Martijn Dijkstra, Jingyuan Fu,Tejas Gandhi, Yang Li, Dewi Matthijssen, Jimmy Omony, Marcel Otten, Richard Scheltema, Morris Swertz, Bruno Tesson, Sheila Timp Jan-Peter Nap, Gerard te Meerman, Peter Terpstra

2 Groningen Bioinformatics Centre GenomicsTranscriptomics Software Engineering Proteomics & Metabolomics

3 Genomics Genetical genomics Jansen & Nap Trends Genetics 2001, 17:388 Jansen Nature Reviews Genetics 2003, 4:145 Jansen & Nap Trends Genetics 2004, 20:223 …of murine stem cells (de Haan, Williams) Bystrykh et al. Nature Genetics 2005, 37:225 …of Arabidopsis (Koornneef, Vreugdenhil) Keurentjes et al. Proc. Natl. Acad. Sci. in press …of C.elegans (Kammenga) Li et al. PLoS Genetics 2006, 2:e222

4 Software Engineering Molecular Genetics Information System (MOLGENIS) Swertz et al. Bioinformatics 2004, 20:2075 Code generation for the life sciences Swertz & Jansen Nature Reviews Genetics in press

5 Transcriptomics Methods for analysing gene expression data RankProducts: Breitling et al. FEBS Letters 2004, 573:83; Breitling & Herzyk J. Bioinf. Comp. Biol. 2005, 3:1171; Hong et al. Bioinformatics 2006, 22:2825 Iterative Group Analysis: Breitling et al. BMC Bioinformatics 2004, 5:34 GiGA: Breitling et al. BMC Bioinformatics 2004, 5:100 VectorAnalysis: Breitling et al. BMC Bioinformatics 2005, 6:181 Linear Factor Models: Girolami & Breitling Bioinformatics 2004, 20:3021 SIMAGE: Albers et al. BMC Bioinformatics 2006, 7:205 Distant Pair Design: Fu & Jansen Genetics 172:1993 Reviews in Benson & Breitling Curr. Mol. Med. 2006, 6:695; Breitling Biochim. Biophys. Acta 2006, 1759:319; Breitling & Herzyk OMICS 2005, 9:225; Alberts et al. Brief. Bioinf. 2005, 6:135

6 Metabolomics Genetical metabolomics of Arabidopsis (Koornneef, Bino, Hall, de Vos) Keurentjes et al. Nature Genetics 2006, 38:842 Ultra-high resolution metabolomics (Barrett, Phenomenome) Breitling et al. Metabolomics 2006, 2:155 Breitling et al. Trends Biotechnol. 2006, 24:543

7 Proteomics 1 Modelling ubiquitin-UBD interactions (Dikic, Blagoev, Mann) Hoeller et al. Nature Cell Biology 2006, 8:163 Predicting protein function from sequence (Gilbert) Al-Shahib et al. Appl. Bioinformatics 2005, 4:195 Al-Shahib et al. Int. J. Neural Systems 2005, 15:259 Deriving protein interaction domains from Y2H data (Higham) Morrison et al. Bioinformatics 2006, 22:2012

8 Proteomics 2 Interpretation of SELDI mass spectra (Vonk, Roelofsen) Dijkstra et al. Proteomics 2006, 6:5106 Dijkstra et al. J. Chromatogr. B in press Genetical kinomics (de Haan, Peppelenbosch) Bioinformatics for membrane protein mass spectra (Poolman, Permentier)


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