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Microprosthetic Implant for the Treatment of Erectile Dysfunction Matt Schwartz and Robert Douglas Advisor – Dr. Franz Baudenbacher.

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Presentation on theme: "Microprosthetic Implant for the Treatment of Erectile Dysfunction Matt Schwartz and Robert Douglas Advisor – Dr. Franz Baudenbacher."— Presentation transcript:

1 Microprosthetic Implant for the Treatment of Erectile Dysfunction Matt Schwartz and Robert Douglas Advisor – Dr. Franz Baudenbacher

2 Thesis A microprosthetic drug delivery implant has the potential to provide a biomimetic treatment option for erectile dysfunction. – Minimally invasive – Patient compliance – Targeted drug release and control

3 Erectile Dysfunction Background Erectile Dysfunction (ED) – Prevalence in men = 52% 1 – Current treatment options Prescription oral pills Injection therapy Penile prosthetics – Drug therapy market size $3.1 billion in 2005 Estimated growth of 6.5% annually through

4 Pathophysiology Physiology of erection Erectile tissue – cavernous smooth muscles – Low blood flow in flaccid state – Stimulation causes arterioles to dilate 3 Neurophysiologoy – Cavernous nerves – neurovascular control of erection/detumescence – Dorsal nerve – sensory function Pathology of ED – Psychogenic – Neurogenic Estimated at 10-19% Iatrogenic – Arteriogenic – Combination

5 Problem and Solution Current solutions – Oral prescription drugs – Injection therapy – Mechanical prosthetics Proposed solution – Drug delivery implant – Triggered by neural signals of dorsal nerve – Microcontroller interprets signal – Microinjector drug release – Microcontroller regulates reactivation

6 Design Parameters Dorsal nerve input interface Drug reservoir, microprocessor, power supply, microinjector – Refillable reservoir – Power saving sleep mode Candidates for drug release – Papaverine – Prostaglandin E1 – Affects reservoir size and flow specifications Surgical Technique and Implantation – Site – Anterior face of pubic bone – Proximity to anatomical targets – Minimally invasive

7 System Flow Chart

8 Microprocessor Flow Chart

9 Timeline of Future Work Week ending 2/6/10 – Finalize list of components needed for proof of concept, consult with Dr. Doug Milam on device parameters Week ending 2/13/10 – Order/fabricate proof of concept components Week ending 2/20/10 – Contact pharmacologist and companies involved with related technologies Week ending 2/27/10 – Assemble proof of concept device, change specifications with Dr. Doug Milam’s recommendations Week ending 3/6/10 – Finalize specifications and component list for scaled up prototype device, order/fabricate components Week ending 3/20/10 – Setup testing scenarios for prototype device Week ending 3/27/10 – Begin assembly of prototype device Week ending 4/3/10 – Complete prototype device assembly, begin device testing Week ending 4/10/10 – Complete device testing, calculate specifications for to-scale device

10 References 1.Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: Results of the Massachusetts Male Aging Study. Urology 1994; 151: Elder, Melissa. Men’s Health: The Worldwide Market for Current and Emerging Drug Therapies, 2 nd ed. Kalorma Information. May Robert C. Dean, MD and Tom F. Lue, MD. Physiology of penile erection and pathophysiology of erectile dysfunction. Urol Clin North Am November; 32(4): 379-v. 4.“Codman 3000.” Codman Pumps. 15 Oct Web.. 5.Sacral Plexus of the Right Side. Gray’s Anatomy.


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