10. Changing Face of Head and Neck Cancer Sturgis EM, Cinciripini PM. Trends in head and neck cancer incidence in relation to smoking prevalence: an emerging epidemic of human papillomavirus-associated cancers? Cancer. 2007 Oct 1;110(7):1429-35. Review.
11. Risk increases with number of lifetime –vaginal-sex partners (26 or more) –oral-sex partners (6 or more) Different Risk Factors D’Souza et al. Case-control study of human papillomavirus and oropharyngeal cancer. N Engl J Med 2007; 356:1944–1956. Sikora AG et al. Bidirectional association of anogenital and oral cavity/pharyngeal carcinomas in men. Arch Otolaryngol Head Neck Surg. 2009 135(4):402-5.
12. Smaller primary tumor Different Presentation Straetmans JM et al. Laryngoscope. 2009 Oct;119:1951-7. Gillison ML et al. JNCI. 2008;100(4):261-269. Bulky/cystic nodal metastasis
13. Trans oral vizualization is limited: Different Presentation
14. Different Histology Basaloid poorly differentiated P16 +HPV +
15. Different Survival Ang KK et al. N Engl J Med 2010;363:24-35
16. Different Risk with Tobacco Exposure Ang KK et al. N Engl J Med 2010;363:24-35
17. HPV is causing an epidemic of oropharynx cancer Affects men more than women Risk of HPV causing oropharynx cancer surpassing that of cervical cancer Conclusion