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The Two Bioinorganic Projects of Research Methodology Fall 2012 Ligand Synthesis Complex Synthesis Biochemical Studies Tetraphenyl porphyrin Pteridinyl.

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Presentation on theme: "The Two Bioinorganic Projects of Research Methodology Fall 2012 Ligand Synthesis Complex Synthesis Biochemical Studies Tetraphenyl porphyrin Pteridinyl."— Presentation transcript:

1 The Two Bioinorganic Projects of Research Methodology Fall 2012 Ligand Synthesis Complex Synthesis Biochemical Studies Tetraphenyl porphyrin Pteridinyl phenanthroline

2 DPPZ L-allox L-aminoL-keto L-UN Types of Pteridinyl Phenanthroline Ligands (and other)

3 Pteridinyl phenanthroline synthesis in NaOH pH ~11 MeOH 20 h or so Ligand Synthesis (by Alexandra)

4 General Description of Ligand Synthesis

5 Group and Ligand Assignments for Synthesis and Characterization Group #Studentsligandcomplex Group 1 — Linda Cho, Katie GuyeDPPZ[Ru(bpy) 2 (DPPZ)](PF 6 ) 2 Group 2 — Rachael Kahlin,Julia HeerL-allox[Ru(bpy) 2 (L-allox)](PF 6 ) 2 Group 3 — Julie Han,Bingqing LiL-amino[Ru(bpy) 2 (L-amino)](PF 6 ) 2 Group 4 — Alicia Makepeace,Misha SimsL-keto[Ru(bpy) 2 (L-keto)](PF 6 ) Group 5 — Terry Huh,Maria NamL-keto[Ru(bpy) 2 (L-keto)](PF 6 ) 2 Group 6 — Anna Kalinsky,Janielle VidalL-keto (to make L-aap)[Ru(bpy) 2 (L-aap)](PF 6 ) 2 Group 7— Chloe Baumann,Sara KimL-UN (to make L-alap)[Ru(bpy) 2 (L-alap)](PF 6 ) 2 ‘Group’ 8 — Alexandra KirschL-tallox (thioalloxazine) [Ru(bpy) 2 (L-tallox)](PF 6 ) 2 DPPZ L-allox L-aminoL-keto L-aap L-alap L-UN w/ Ru

6 Group and Ligand Assignments for Synthesis and Characterization Group #Studentsligandcomplex Group 1 — Linda Cho, Katie GuyeDPPZ[Ru(bpy) 2 (DPPZ)](PF 6 ) 2 Group 2 — Rachael Kahlin,Julia HeerL-allox[Ru(bpy) 2 (L-allox)](PF 6 ) 2 Group 3 — Julie Han,Bingqing LiL-amino[Ru(bpy) 2 (L-amino)](PF 6 ) 2 Group 4 — Alicia Makepeace,Misha SimsL-keto[Ru(bpy) 2 (L-keto)](PF 6 ) Group 5 — Terry Huh,Maria NamL-keto[Ru(bpy) 2 (L-keto)](PF 6 ) 2 Group 6 — Anna Kalinsky,Janielle VidalL-keto (to make L-aap)[Ru(bpy) 2 (L-aap)](PF 6 ) 2 Group 7— Chloe Baumann,Sara KimL-UN (to make L-alap)[Ru(bpy) 2 (L-alap)](PF 6 ) 2 ‘Group’ 8 — Alexandra KirschL-tallox (thioalloxazine) [Ru(bpy) 2 (L-tallox)](PF 6 ) 2 DPPZ L-allox L-aminoL-keto L-UN Phenylene diamine 5,6 –diamino 2,4 dihydroxy pyrimidine 4,5,6 –triamino pyrimidine 5,6 –diamino 4-hydroxy pyrimidine 5,6 –diamino pyrimidine

7 True or false? Blood is red because of the iron in hemoglobin. “Red blood cells” A close-up of red blood cells within a capillary. Over 99 percent of the blood vessels in the body are capillaries, even though they only hold 5 percent of the body’s blood.

8 False por·phy·rin Function: noun Etymology: from Greek porphyra purple -any of various compounds with a macrocyclic structure that consists essentially of four pyrrole rings joined by four =CH- groups; especially : one (as chlorophyll or hemoglobin) containing a central metal atom and usually exhibiting biological activity

9 Protoporphyrin IX Glycine + Succinyl CoA the pyrrole ring is formed Nature’s synthesis of Porphyrin

10 The Adler synthesis of simple, symmetrically substituted porphyrins: Meso position R = phenyl (TPP) toluyl (TTP) p-chlorophenyl (TClPP)

11 Ligand Synthesis: Condensations are a Theme Schiff-Base Ligands

12 (Thanks, Eesha….)

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