It is not to say that you cannot breed two animals, it only says they may not have an EI compatibility.
You can mix and match and breed parents with different EI imbalances and produce an average without an imbalance.
Example – a female Brittany spaniel, a national field trial champion named CeCe, had low cortisol, high adrenal estrogen, suppressed T3T4 and deregulated B & T cells, not only did she stop running and could not become pregnant, she developed “Valley Fever” due to her suppressed T cells.
CeCe was good enough as a national field trial champion that the owners decided to breed her. The male that was picked was “Sundance”, he had a high cortisol, more normal adrenal estrogen, and a normal thyroid.
CeCe had a litter – the offspring appeared normal, I was given one of the puppies and chose to name her Murphy’s law!
At 7 months her EI levels and littermates levels were normal.
If you identify the EI imbalance in parents you can breed it out. The imbalance is in their off- spring.
We need to have healthy animals so that young people like this can become Veterinarians.