A Day in the Life of a Clinical Laboratory Animal Veterinarian Research Opportunities Fun Facts
Provide for the health and well-being of animals used in research and testing Laboratory Animal Medicine Study of biology and disease in animal models to improve human and animal health Comparative Medicine Research
Research Clinical Medicine Pathology and Diagnostics Surgery Teaching and Training Administration Diverse and interesting jobs Research Surgery Pathology Clinical Medicine
No two days are the same! Multiple components to a clinician’s job Veterinary Care Husbandry Oversight Model Development/Refinement Investigator Collaboration/Support Training Compliance Protocol Review Post-Approval Monitoring Training
Herd Health Preventative Medicine Dog/Cat NHP Rodent Outbreak Management Research Outcomes vs. Treatment Options Will a treated animal still be a useful research model? Model related disease vs. spontaneous disease
You are the “Expert”! Wide variety of species Regulatory Component Cage size – USDA, The Guide for Care and Use of Laboratory Animals Changing/Sanitization frequency Animal Wellbeing Diet Bedding Types Breeding Concerns All must be kept in the context of the research they are supporting!!!!!!!
“Hey Doc, I want to study heart disease in… Mouse Rat Pig How do I do it?” “Hey Doc, I have this mouse that gets heart disease, but it doesn’t show the signs I need it to. Any thoughts?” How can you help? This is where you can really help investigators by standing in the hallway and talking to them. Communication is the KEY!
Alternatives to animal models How can you help? 3 (4) R’s Reduce the number of animals used Refine methods Replace animal models with other systems (Respect/Responsibility)
Model Development/Refinement Model Support Surgical Model Development (VAP placement) Specialized Veterinary Needs (DMD) Technical Support/Training Breeding Colony Problems Training
PI and their staff Graduate students Veterinary students Public at large
Animal Care and Use Committee (ACUC) Animal Use Protocols Pre-review Animal Care Quality Assurance Post-Approval Monitoring Compliance Animal welfare concerns Best cure for most compliance issues is an ounce of prevention (lots of communication and training!)
Coupling of interests Veterinary medicine Research Post-DVM programs devoted to training in research and veterinary specialties Examples of research-oriented specialties American College of Laboratory Animal Medicine (ACLAM) American College of Veterinary Pathology (ACVP) American College of Veterinary Anesthesiologists (ACVA) American College of Veterinary Internal Medicine (ACVIM) High demand / good pay Variety of career opportunities
Develop hypotheses Perform investigations Observe and interpret outcomes Establish conclusions Prepare grants and manuscripts Become experts in their fields Peter Doherty, DVM, PhD Nobel Laureate, 1996
Basic Clinical / Applied Veterinary Questions Human Health Questions Primary Investigators Collaborative Scientists Translational Research } } One Health One Medicine
One health initiative http://onehealthinitiative.com/index.php
Technology development for organ transplantation
Examples of Comparative Medicine Research Development for mouse models of cancer metastasis
Example of Micro-CT Image Data Volume rendering of Micro-CT image data. CTI-Concorde LLC MicroCAT II™ Micro-CT Micro-CT Coronal Section
Day 21Day 27Day 35Day 43 Progression of a Tibial Metastasis 0.75 mm1.4 mm2.3 mm ?
Average Lab Animal Vet Salary (2011) = $162,336 Highest = $500,000 Lowest = $53,000 Consulting to supplement Average = $17,154 Residency Salaries Start at $36,996 Post DVM/PhD training (SERCA) Up to $75,000 http://www.aclam.org/
Independent and Collaborative Research Improving human and animal life Veterinary Care Development and refinement of animal models Development of alternatives to animals
Externships / electives Comparative Medicine Clubs Student member of ASLAP, ACVP, etc Meeting opportunities Talk to Comparative Medicine Scientists and Laboratory Animal Veterinarians Post-DVM training programs
What? 3-12 weeks Summer research programs Flexible Many are paid!!!!! Where? Academia – training programs Biotech & pharmaceutical companies NIH, USDA Primate centers How to find? Visit the web