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EDITING SLIDES IN THE NOVOZYMES TEMPLATE Choose Layout: Click Layout in the top menu Home. And choose between +30 different layouts. Edit Header and footer:

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Presentation on theme: "EDITING SLIDES IN THE NOVOZYMES TEMPLATE Choose Layout: Click Layout in the top menu Home. And choose between +30 different layouts. Edit Header and footer:"— Presentation transcript:

1 EDITING SLIDES IN THE NOVOZYMES TEMPLATE Choose Layout: Click Layout in the top menu Home. And choose between +30 different layouts. Edit Header and footer: In the top left corner you find Slide no., Date and Header. Change settings in the menu: > Insert > Header and Footer EDITING SLIDES IN THE NOVOZYMES TEMPLATE Choose Layout: Click Layout in the top menu Home. And choose between +30 different layouts. Edit Header and footer: In the top left corner you find Slide no., Date and Header. Change settings in the menu: > Insert > Header and Footer guide 4/30/ Enzymes for surgical cleaners

2 AGENDA SLIDE Use: Help the audience to a better understanding of the presentation progression by visualizing the agenda when changing topic. NOVOZYMES COLORS Find: The Novozymes CVI compliant colors under Custom Colors. AGENDA SLIDE Use: Help the audience to a better understanding of the presentation progression by visualizing the agenda when changing topic. NOVOZYMES COLORS Find: The Novozymes CVI compliant colors under Custom Colors. guide NOVOZYMES PRESENTATION24/30/2015 Surgical cleaners Enzymatic detergents Biofilm CONTENT

3 BULLETS IN PLANES 2 Animation: The plane in the back is fixed. Plane (Today green) in front is animated: Fade on click. Use: To highlight information when discussing past and future situations. BULLETS IN PLANES 2 Animation: The plane in the back is fixed. Plane (Today green) in front is animated: Fade on click. Use: To highlight information when discussing past and future situations. guide Challenges for surgical cleaners NOVOZYMES PRESENTATION34/30/2015 "...in the absence of careful physical cleaning, most disinfection and sterilization processes are likely to be ineffective. …only steam autoclaving can overcome the barrier effects of residual organic matter." Source: Gastrointestinal Endoscopy Vol 50 no , pg 288  Removal of body tissue soils like blood, mucous, fats, and others  Reduction of biofilms

4 PICTURE Edit: Insert picture by clicking icon in plane. PICTURE Edit: Insert picture by clicking icon in plane. guide NOVOZYMES PRESENTATION44/30/2015. Formulation types of surgical cleaners  Neutral pH Detergent (pH 6 – 8)  Alkaline pH Detergent (pH 10-12)  Enzymatic Detergent (~Neutral, pH 7-8)  Single enzyme (e.g., protease or lipase)  Multi-enzyme (protease, lipase, amylase, cellulase…)

5 PICTURE Edit: Insert picture by clicking icon in plane. PICTURE Edit: Insert picture by clicking icon in plane. guide NOVOZYMES PRESENTATION54/30/2015. Intended use of surgical cleaners High or low impingement washers Manual applications Ultrasonic Presoak Stain Removal

6 ANIMATED SPRAY Animation: (Motion Path of Clover) A coloured shadow moves in the background and disappears. Use: The Spray is used to represent transition, information share and the creation of new, cutting edge solutions. ANIMATED SPRAY Animation: (Motion Path of Clover) A coloured shadow moves in the background and disappears. Use: The Spray is used to represent transition, information share and the creation of new, cutting edge solutions. guide  Effective cleaning of endoscopes is essential  Endoscopes have fragile parts and should not be exposed to high temperatures (>60°C) and autoclaving  Flexible endoscope must be decontaminated by cleaning at low temperatures and disinfected by cold chemicals  Cleaning of flexible endoscopes is classified as a semi- critical instrument since it penetrates skin and tissue.  Must be disinfected with a high level disinfector (HLD) Example of process – endoscope cleaning NOVOZYMES PRESENTATION64/30/2015

7 BASIC LAYOUT Use: This is the basic slide with no extra Novozymes graphics added. Edit Layout: Click Layout in the top menu Home. And choose between +30 different layouts. Edit Header and footer: In the top left corner you find Slide no., Date and Header. Change settings in the menu: > Insert > Header and Footer BASIC LAYOUT Use: This is the basic slide with no extra Novozymes graphics added. Edit Layout: Click Layout in the top menu Home. And choose between +30 different layouts. Edit Header and footer: In the top left corner you find Slide no., Date and Header. Change settings in the menu: > Insert > Header and Footer guide Types of surgical instruments and their use NOVOZYMES PRESENTATION74/30/2015 Flexible endoscopes Heat labile – can not be autoclaved Gastro-Intestinal inspections 10 million inspections/year in US (1995) Rigid endoscopes Laparoscopes Abdominal; minimum invasive surgery 4.4 million inspections/ year in US

8 BASIC LAYOUT Use: This is the basic slide with no extra Novozymes graphics added. Edit Layout: Click Layout in the top menu Home. And choose between +30 different layouts. Edit Header and footer: In the top left corner you find Slide no., Date and Header. Change settings in the menu: > Insert > Header and Footer BASIC LAYOUT Use: This is the basic slide with no extra Novozymes graphics added. Edit Layout: Click Layout in the top menu Home. And choose between +30 different layouts. Edit Header and footer: In the top left corner you find Slide no., Date and Header. Change settings in the menu: > Insert > Header and Footer guide NOVOZYMES PRESENTATION30/04/ The optimal process of endoscope cleaning (WGO) Use of device Rinsing with water and manual cleaning with detergent Automatic cleaning with detergent Disinfection Rinsing with bacteria-free water or alcohol Drying Storage

9 BASIC LAYOUT Use: This is the basic slide with no extra Novozymes graphics added. Edit Layout: Click Layout in the top menu Home. And choose between +30 different layouts. Edit Header and footer: In the top left corner you find Slide no., Date and Header. Change settings in the menu: > Insert > Header and Footer BASIC LAYOUT Use: This is the basic slide with no extra Novozymes graphics added. Edit Layout: Click Layout in the top menu Home. And choose between +30 different layouts. Edit Header and footer: In the top left corner you find Slide no., Date and Header. Change settings in the menu: > Insert > Header and Footer guide NOVOZYMES PRESENTATION30/04/ The optimal process of endoscope cleaning (WGO) Step 3-6 Washing, disinfection, rinsing with bacteria-free water or alcohol & drying Room 2 - The dirty room Step 2 Rinsing with water And manual cleaning Room 3 - The reprocessing room Room 4 - The storage room Step 7 Storage Step 1 Use of the Device Room 1 - The Operating room

10 BULLETS IN PLANES 2 Animation: The plane in the back is fixed. Plane (Today green) in front is animated: Fade on click. Use: To highlight information when discussing past and future situations. BULLETS IN PLANES 2 Animation: The plane in the back is fixed. Plane (Today green) in front is animated: Fade on click. Use: To highlight information when discussing past and future situations. guide Washing with detergents NOVOZYMES PRESENTATION1030/04/2015  This is the part of the cleaning process where enzymes are applicable  This part of the reprocessing process is very important, since inadequate cleaning and removal of biofilm inhibits disinfection as defined by AAMI  There are two methods of washing/cleaning: manual and automatic Disinfection is defined as: “The process of removing as much of the contamination as possible, but not necessarily killing the microorganism.” Source: TIR 30 – A Compendium of cleaning of medical devices” by AAMI (2003) (TIR 30)

11 ANIMATED HORIZONTAL FLOWER Animation: (Motion Path of horizontal flower) A coloured shadow moves in the background and disappears. Use: The Horizontal Floral is used to represent transition, information share and the creation of new, cutting edge solutions. ANIMATED HORIZONTAL FLOWER Animation: (Motion Path of horizontal flower) A coloured shadow moves in the background and disappears. Use: The Horizontal Floral is used to represent transition, information share and the creation of new, cutting edge solutions. guide  Enzymatic detergents are recommended in both Europe (ESGE), in the US (Multi-society guidelines) and globally (WGO)  Can be positioned as a environmental friendly and more safe to handle substitute to more harsh detergents  They are often the detergent of choice since they are effective at dissolving proteins and operate at low temperatures in a neutral environment  The majority of the guidelines recommend that the health care facility uses the detergent recommended by the manufacturer of the AER  The majority of the enzymatic detergents are multi-purposed and can be used in almost all the automatic cleaners and as a manual cleaner  The manufacturers of the detergents use the enzymes as a selling point in their brochures using between one to four different enzymes in their detergents (protease, lipase, amylase, and cellulase) Enzymatic detergents NOVOZYMES PRESENTATION114/30/2015

12 CONTENT HOLDER 2 Edit: Click on the icons in Content Holder to insert, tables, charts, smart art, pictures, clipart and movies. Or add simple text. CONTENT HOLDER 2 Edit: Click on the icons in Content Holder to insert, tables, charts, smart art, pictures, clipart and movies. Or add simple text. guide GET FASTER BLOOD REMOVAL WITH ENZYMATIC DETERGENTS Complete blood removal with proteases NOVOZYMES PRESENTATION124/30/2015 BLOOD IS THE MAIN AND MOST CRITICAL CONTAMINANT OF SURGICAL INSTRUMENTS AND IT IS USED IN THE INTERNATIONAL STANDARD ISO15883 AS CHOSEN TEST SOIL (TOSI TEST) TO CHECK THE EFFICACY OF CLEANING PROCEDURES FOR SURGICAL INSTRUMENTATION REPROCESSING Time taken in min. to clean Test stopped

13 PICTURE Edit: Insert picture by clicking icon in plane. PICTURE Edit: Insert picture by clicking icon in plane. guide NOVOZYMES PRESENTATION134/30/2015 Reasons for cleaning BLOOD FIXATION BY STERILIZING AGENTS (GLUTARALDEHYDE, PERACETIC ACID)

14 DOUBLE CONTENT HOLDERS WITH CLOVER ANIMATION (COLOR: PINK) Animation: Clover animation fades from left to right. Edit: Click on the icons in Content Holder to insert, tables, charts, smart art, pictures, clipart and movies. Or add simple text. DOUBLE CONTENT HOLDERS WITH CLOVER ANIMATION (COLOR: PINK) Animation: Clover animation fades from left to right. Edit: Click on the icons in Content Holder to insert, tables, charts, smart art, pictures, clipart and movies. Or add simple text. guide Endoscope cleaners in Brazil contain three to four enzymes NOVOZYMES PRESENTATION144/30/2015 Endoscope cleaners launched in Brazil containing only one enzyme Endoscope cleaners launched in Brazil containing more than one enzyme

15 BULLETS IN PLANES 2 Animation: The plane in the back is fixed. Plane (Today green) in front is animated: Fade on click. Use: To highlight information when discussing past and future situations. BULLETS IN PLANES 2 Animation: The plane in the back is fixed. Plane (Today green) in front is animated: Fade on click. Use: To highlight information when discussing past and future situations. guide Examples of enzymatic cleaners NOVOZYMES PRESENTATION154/30/2015. Asepti-zyme from Ecolab is marketed as a multi-purpose detergent that can be used for manual decontamination, scope washer/disinfectors, ultrasonics, washers and sterilizers, and washer decontaminators, and as a detergent that delivers: Rapid action Dissolves proteinacious matter Super-concentrated Low foaming - saves time

16 BULLETS IN PLANES 2 Animation: The plane in the back is fixed. Plane (Today green) in front is animated: Fade on click. Use: To highlight information when discussing past and future situations. BULLETS IN PLANES 2 Animation: The plane in the back is fixed. Plane (Today green) in front is animated: Fade on click. Use: To highlight information when discussing past and future situations. guide Examples of enzymatic cleaners NOVOZYMES PRESENTATION164/30/2015 Kimberly Clark’s multi–enzyme detergent for manual Cleaning is marketed as: Effective; rapidly removes all types of soils (fats, carbohydrate and protein) Compatible; can be used with a wide range of devices Low-Foaming; appropriate for manual and small washer use Easy-To-Use; pump dispenses consistent 1 ounce dose User-Friendly; pleasant fragrance in an ergonomically  designed package Process-Friendly; easily integrates into your current practices Environment-Friendly; biodegradable and phosphate- free

17 BULLETS IN PLANES 2 Animation: The plane in the back is fixed. Plane (Today green) in front is animated: Fade on click. Use: To highlight information when discussing past and future situations. BULLETS IN PLANES 2 Animation: The plane in the back is fixed. Plane (Today green) in front is animated: Fade on click. Use: To highlight information when discussing past and future situations. guide Examples of enzymatic cleaners NOVOZYMES PRESENTATION174/30/2015 Korsolex Endo-cleaner from Bode is marketed as: Excellent solving capacity for oil, dirt, blood and biofilm High degree of material compatibility for machine and endoscope Little foaming Economical Phosphate-free Environmentally friendly Compatible with Korsolex® Endo-Disinfectant

18 BULLETS IN PLANES 2 Animation: The plane in the back is fixed. Plane (Today green) in front is animated: Fade on click. Use: To highlight information when discussing past and future situations. BULLETS IN PLANES 2 Animation: The plane in the back is fixed. Plane (Today green) in front is animated: Fade on click. Use: To highlight information when discussing past and future situations. guide Examples of enzymatic cleaners NOVOZYMES PRESENTATION184/30/2015 PRO EZ 2 from Certol is marketed as:  Dual enzymatic action dissolves both protein and starch containing soils.  Superior surfactants remove loosened soils and emulsify fats  Use as a presoak  Multipurpose: used in manual, ultrasonic, or automated  systems  Reduces unpleasant odors  Gentle, neutral pH and non-corrosive  The dispensing pump takes the guess work out of measuring

19 BASIC LAYOUT Use: This is the basic slide with no extra Novozymes graphics added. Edit Layout: Click Layout in the top menu Home. And choose between +30 different layouts. Edit Header and footer: In the top left corner you find Slide no., Date and Header. Change settings in the menu: > Insert > Header and Footer BASIC LAYOUT Use: This is the basic slide with no extra Novozymes graphics added. Edit Layout: Click Layout in the top menu Home. And choose between +30 different layouts. Edit Header and footer: In the top left corner you find Slide no., Date and Header. Change settings in the menu: > Insert > Header and Footer guide Novozymes’ positioning in I&I surgical cleaner market NOVOZYMES PRESENTATION194/30/2015 Segment Novozymes preferred products Selling points Competitor product NZ product discriminator Surgical instrument reprocessing Alcalase / Esperase/ Alcalase Ultra Stainzyme Lipex Viscozyme Enables improved cleaning at low temperatures Attacks all food residue and body soils efficiently Extended equipment lifetime Less hazardous chemicals to handle Cleaning and hygiene in 1 step Ultra to offset MPG costs Mainly competing with Peroxyacetic acid and surfactants and glutaraldehyde based detergents Better overall performance, milder conditions Less toxic chemicals

20 ANIMATED VERTICAL FLOWER Animation: Grows from below with fading clover. Use: The Vertical Floral texture is used to represent a celebration of achievement and recognition of success. ANIMATED VERTICAL FLOWER Animation: Grows from below with fading clover. Use: The Vertical Floral texture is used to represent a celebration of achievement and recognition of success. guide Biofilms are ubiquitous in nature and cause a variety of problems including:  Fouling of membranes  Biological fouling in medical instruments, oil field injection wells, and cooling towers  Infections and disease in people (e.g., contamination of drinking water and dental unit water)  Oral care/plaque buildup  Corrosion of metal surfaces by sulfur- reducing bacteria (SRB’s) Companies are attempting to address most of these areas using detergent-type Cleaners. The problem with biofilms NOVOZYMES PRESENTATION204/30/2015

21 ANIMATED VERTICAL FLOWER Animation: Grows from below with fading clover. Use: The Vertical Floral texture is used to represent a celebration of achievement and recognition of success. ANIMATED VERTICAL FLOWER Animation: Grows from below with fading clover. Use: The Vertical Floral texture is used to represent a celebration of achievement and recognition of success. guide For initial formulation trials, in an endoscope cleaner used at a 5% concentration in the cleaning bath, the recommended dosage levels of liquid enzymes are: Typical enzyme dosages NOVOZYMES PRESENTATION214/30/2015 Enzyme Category Typical enzyme dosage in the detergent, wt% Proteases10% (Savinase 16 L, Everlase 16 L, Alcalase 2.5 L, Esperase 8.0 L, Liquanase 2.5 L) Amylases8% (Termamyl 300 L, Duramyl 300 L) 6% (Stainzyme 12 L, Stainzyme Plus 12 L) Lipases5% (Lipex 100 L, Lipolase 100 L) Cellulases5 % (Novozym 342, Celluzyme, Viscozyme)

22 BASIC LAYOUT Use: This is the basic slide with no extra Novozymes graphics added. Edit Layout: Click Layout in the top menu Home. And choose between +30 different layouts. Edit Header and footer: In the top left corner you find Slide no., Date and Header. Change settings in the menu: > Insert > Header and Footer BASIC LAYOUT Use: This is the basic slide with no extra Novozymes graphics added. Edit Layout: Click Layout in the top menu Home. And choose between +30 different layouts. Edit Header and footer: In the top left corner you find Slide no., Date and Header. Change settings in the menu: > Insert > Header and Footer guide Polysaccharides produced by bacteria in biofilms NOVOZYMES PRESENTATION224/30/2015 EPS PolymerLinkageBacteria Alginates -1,4 mannuronic acid -1,4 guluronic acid Pseudomonas Amylopectin -1,4 & -1,6 glucose Ecoli Celluloses -1,4 glucose Acetobacter Colanic AcidsGlucose, galactose, fucose, glucuronic acid, pyruvic acid Salmonella, Ecoli Dextrans -1,6 & -1,4 glucose Streptococcus, Acetobacter Glycogen -1,4 & -1,6 glucose Bacillus, Pneumococci Levans -2,6 fructose Pseudomonas, Bacillus, Aerobacter Polymannans -1,4 mannose Desulfovibrio desulfuricans

23 PICTURE Edit: Insert picture by clicking icon in plane. PICTURE Edit: Insert picture by clicking icon in plane. guide NOVOZYMES PRESENTATION234/30/2015. How can enzymes help Enzymes are able to facilitate biofilm removal from surfaces in an environmentally-friendly manner Enzymes enable targeted removal of contaminants from surfaces without causing deleterious effects to the surface (e.g., pH-sensitive membranes and temperature- sensitive surgical instruments) Enzymes may be able to bypass bacterial defense mechanisms that can inactivate common cleaning agents (e.g., bacterial catalases for H 2 O 2 )

24 ANIMATED HORIZONTAL FLOWER Animation: (Motion Path of horizontal flower) A coloured shadow moves in the background and disappears. Use: The Horizontal Floral is used to represent transition, information share and the creation of new, cutting edge solutions. ANIMATED HORIZONTAL FLOWER Animation: (Motion Path of horizontal flower) A coloured shadow moves in the background and disappears. Use: The Horizontal Floral is used to represent transition, information share and the creation of new, cutting edge solutions. guide  Grow biofilms of relevant organism(s) in minimal media on polycarbonate or stainless steel coupons in CDC reactors (stirred cell, batch mode (non-CSTR) – typically for 2 days)  Treat biofilm-coated coupons with various cleaning products with and without enzymes  Stain coupons with crystal violet solution  Measure the biofilm removal index (BRI) instrumentally ((based on ASTM D ) BRI = 100 – [(L clean -L treated ) 2 + (a clean – a treated ) 2 + (b clean – b treated ) 2 ] 1/2 Typical biofilm screening methodology NOVOZYMES PRESENTATION2430/04/2015

25 CONTENT HOLDER 3 Edit: Click on the icons in Content Holder to insert, tables, charts, smart art, pictures, clipart and movies. Or add simple text. CONTENT HOLDER 3 Edit: Click on the icons in Content Holder to insert, tables, charts, smart art, pictures, clipart and movies. Or add simple text. guide, Multi-enzyme solution can help detergents remove biofilm NOVOZYMES PRESENTATION254/30/2015 THE SURGICAL INSTRUMENTS WERE SOAKED FOR 60 MIN AT 40°C This data is based on the removal of Model Pseudomonas auerginosa biofilm, a common microbe found on surgical instruments UnsoakedSoaked in detergent Soaked in detergent + multi-enzyme solution L* Values for Soaked Coupons Containing Pseudomonas Auerginosa biofilm Detergent+E2Detergent+E1Detergent onlyNo Soaking Treatment L*

26 BULLETS IN PLANES 2 Animation: The plane in the back is fixed. Plane (Today green) in front is animated: Fade on click. Use: To highlight information when discussing past and future situations. BULLETS IN PLANES 2 Animation: The plane in the back is fixed. Plane (Today green) in front is animated: Fade on click. Use: To highlight information when discussing past and future situations. guide Comments on disinfection NOVOZYMES PRESENTATION264/30/2015 NHS statement on disinfection “It is not considered acceptable to use Glutaraldehyde for endoscope disinfection in the United Kingdom.”  Disinfection is a separate step of the reprocessing of the flexible Endoscope  The specific substance used for disinfection varies around the world due to different recommendations in the different countries  One of the most commonly used disinfectors globally for endoscopes is Glutaraldehyde followed by Peracetic acid  Glutaraldehyde is an asthmagen and there is a rising concern, especially in the West, about the use of this substance  Glutaraldehyde is still the most used disinfector in the rest of the world**, while the US authorities recommend that you do not use unless its absolutely necessary*** * A program under the British health authorities. ** Danish recommendations from SSI ( Statens Serum Insititut) and statistics from ESGE and WGO ***Recommendations from the Center for Disease control (CDC), the Association for the Advancement of Medical Instrumentation (AAMI) and Association of practitioners in infection control (APIC) and WGO.

27 BASIC LAYOUT Use: This is the basic slide with no extra Novozymes graphics added. Edit Layout: Click Layout in the top menu Home. And choose between +30 different layouts. Edit Header and footer: In the top left corner you find Slide no., Date and Header. Change settings in the menu: > Insert > Header and Footer BASIC LAYOUT Use: This is the basic slide with no extra Novozymes graphics added. Edit Layout: Click Layout in the top menu Home. And choose between +30 different layouts. Edit Header and footer: In the top left corner you find Slide no., Date and Header. Change settings in the menu: > Insert > Header and Footer guide The different disinfectors – categorized NOVOZYMES PRESENTATION274/30/2015 Disinfectant basePropertiesExamples Alkylating agents Superior materials compatability Tend to be in a higher COSHH Essentials hazard group than oxidising agents Their ability to fix protein may limit use of some products (e.g glutaraldehyde) Glutaraldehyde (Cidex, ASEP, Totacide) Ortho-phthalaldehyde (OPA, Cidex-OPA) Mixtures (Gigasept rapid, Septo DN) Oxidising agents Superior sponcidal activity Tend to be in a lower COSHH Essentials hazard group than oxidising agents May be incompatible with some endoscopes Chlorine-containing compounds (Sterilox, Tristel) Peroxygen compounds (Virkon S) Perasetic acid (Nu Cidex, Steris, Aperlan)

28 NOVOZYMES PRESENTATION284/30/2015 OUTRO 2 Use: Thank your Audience for listening Animation: Auto Super graphic light animation. The Outro slide turns completely black after 10 sec.. OUTRO 2 Use: Thank your Audience for listening Animation: Auto Super graphic light animation. The Outro slide turns completely black after 10 sec.. guide NOVOZYMES PRESENTATION284/30/2015 THANK YOU LEARN MORE ABOUT OUR I&I SOLUTIONS AT


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