We think you have liked this presentation. If you wish to download it, please recommend it to your friends in any social system. Share buttons are a little bit lower. Thank you!
Presentation is loading. Please wait.
Published byClayton Leed
Modified about 1 year ago
Table 1 The role of microRNAs in cancers microRNAsTumorigenesis miR-9Neuroblastoma miR-10bBreast cancer miR-15, miR-15aLeukemia, pituitary adenoma miR-16, miR-16-1Leukemia, pituitary adenoma miR-17-5p, miR-17-92Lung cancer, lymphoma miR-20aLymphoma, lung cancer miR-21Breast cancer, cholangiocarcinoma, head & neck cancer, leukemia, cervical cancer, Pancreatic cancer miR-29, miR-29bLeukemia, cholangiocarcinoma miR-31Colorectal cancer miR-34aPancreatic cancer, Neuroblastoma miR-96Colorectal cancer miR-98Head & neck cancer miR-103Pancreatic cancer miR-107Leukemia, pancreatic cancer miR-125a, miR-125bNeuroblastoma, breast cancer miR-128Glioblastoma miR-133bColorectal cancer miR-135bColorectal cancer miR-143Colon cancer, cervical cancer miR-145Breast cancer, colorectal cancer miR-146Thyroid carcinoma miR-155Breast cancer, leukemia, pancreatic cancer miR-181, miR-181a, miR-181cLeukemia, glioblastoma, thyroid carcinoma miR-183Colorectal cancer miR-184Neuroblastoma miR-196a-2Pancreatic cancer miR-221Glioblastoma, thyroid carcinoma, Pancreatic cancer miR-222Thyroid carcinoma miR-223Leukemia miR-301Pancreatic cancer miR-376Pancreatic cancer let-7, let-7a, let-7a-1, let-7a-3Lung cancer, colon cancer Mol Cancer. 2007; 6: 60. Published online 2007 September 25. doi: / Copyright © 2007 Cho; licensee BioMed Central Ltd.
Let-7g impairs proliferation and enhances cell death. Kumar M S et al. PNAS 2008;105: ©2008 by National Academy of Sciences
Let-7g-induced tumors maintain overexpression and target suppression. Kumar M S et al. PNAS 2008;105: ©2008 by National Academy of Sciences
Let-7g suppresses tumorigenesis in vivo. Kumar M S et al. PNAS 2008;105: ©2008 by National Academy of Sciences
K-RasG12D substantially rescues let-7g-mediated tumor suppression. Kumar M S et al. PNAS 2008;105: ©2008 by National Academy of Sciences
Let-7g suppresses tumor initiation in an autochthonous NSCLC model. Kumar M S et al. PNAS 2008;105: ©2008 by National Academy of Sciences
miR-26a is amplified in glioma. Huse J T et al. Genes Dev. 2009;23: ©2009 by Cold Spring Harbor Laboratory Press
miR-26a-expressing murine gliomas (P/26a). Huse J T et al. Genes Dev. 2009;23: ©2009 by Cold Spring Harbor Laboratory Press
miR-26a facilitates gliomagenesis in vivo. Huse J T et al. Genes Dev. 2009;23: ©2009 by Cold Spring Harbor Laboratory Press
miR-26a represses PTEN expression in murine gliomas. Huse J T et al. Genes Dev. 2009;23: ©2009 by Cold Spring Harbor Laboratory Press
Ann E. Rougvie Nature Reviews Genetics 2, (September 2001)
Figure 1 Cell , DOI: ( /S (04) )
Table 1 The role of microRNAs in cancers microRNAsTumorigenesis miR-9Neuroblastoma miR-10bBreast cancer miR-15, miR-15aLeukemia, pituitary.
Progress on Biomarkers of Cancer Diagnosis and Prognosis Majid Kheirollahi Isfahan University of Medical Sciences Ph.D, Medical Genetics Department of.
Progress on Biomarkers of Cancer Diagnosis and Prognosis William CS CHO May 22, 2010 Queen Elizabeth Hospital, Hong Kong.
Dysregulation of the miR-34a-SIRT1 axis inhibits breast cancer stemness Gary Xiao, Ph.D. Professor and Director School of Pharmaceutical Science & Technology.
An Introduction to Nervous Systems © 2007 by Cold Spring Harbor Laboratory Press. Chapter 8, Figure 1.
Chapter 5: Growth Factors, Receptors, and Cancer.
Somatic Mutation Distributions Determining Cut-offs Supp. Figure 5.
FRENCH high-resolution studies - Breast cancer: 1990, 1997, 2003, 2010 ? - Colorectal cancer: 1990, 1995, 2000, 2005, 2010 ? - Prostate cancer: 1995,
Targil – Signal transduction. (Further acting – through the bloodstream – endocrine) Communication between cells.
Reporting on Scientific Journal Articles Jeremy Moore, M.A. Senior Manager, Science Communications American Association for Cancer Research
From a to α Yeast as a Model for Cellular Differentiation © 2007 by Cold Spring Harbor Laboratory Press. Chapter 3, Figure 1.
Causes and consequences of microRNA dysregulation in cancer Hulusi Onur Kuzucu
Advanced Cancer Topics Journal Review 4/16/2009 AD.
Karli Has Cancer Group Discussion 1.In what ways is Karli different from you? 2.What does Karli mean when she says people “don’t understand that cancer.
In describing a person’s cancer what would T2 mean? In describing a person’s cancer what does M1 mean? In describing a person’s cancer what does N0 mean?
INTEGRATED ANALYSIS OF THE MOLECULAR DEREGULATIONS OF THE MDM2:P53 AXIS IN DDLPS KATE LYNN BILL, JEANNINE GARNETT, CHAD CREIGHTON, XIAOYAN MA, ISABELLE.
PrognoScan A new database for meta-analysis of the prognostic value of genes 1 Hideaki Mizuno, Kunio Kitada, Kenta Nakai, Akinori Sarai BMC Med Genomics.
Therapeutic miRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model Janaiah Kota,1 Raghu R. Chivukula,2 Kathryn A. O’Donnell,3,4 Erik A.
Chapter 19 Cancer and the Immune System Dr. Capers.
MiR-137 Modulates a Tumor Suppressor Network-Inducing Senescence in Pancreatic Cancer Cells Mathieu Neault, Frédérick A. Mallette, Stéphane Richard Cell.
University of São Paulo - Brazil Laboratory of Medical Investigation – Urology Antagonism between miR-21 and 338-3p in prostate cancer invasion through.
CANCER, ONCOGENES AND TUMOUR SUPPRESSOR GENES PHL 425 Dr. Mohamed M. Sayed-Ahmed 1/1/2015.
NF- B SOLID TUMORS HEMATOLOGICAL MALIGNANCIES Multiple Myeloma Mantle Cell Lymphoma MALT Lymphoma Diffuse Large B-cell Lymphoma Hodgkin’s Lymphoma Myelodysplasic.
Tumorigenesis to Cancer Development Pin Ling ( 凌 斌 ), Ph.D. ext 5632; References: 1.Chapter 23 Cancer in “Molecular Cell Biology”
Target therapy for bone metastatic prostate cancer with Micro RNA145 inhibits tumor growth in vivo Alexandre Iscaife; Denis Reis Morais; Sabrina Thalita.
Cancer, Oncogenes and Tumour suppressor Genes 1 Dr. Mohamed M. Sayed-Ahmed.
Chapter 21 Cancer and the Immune System Dr. Capers.
Cancer By Andrew Mallorca and Francis Agbejimi. Causes of Cancer Cancer occurs when cells become abnormal and keep dividing and forming more cells without.
CONTEXT SPECIFIC ROLE OF DEUBIQUITYLASE ENZYME, USP9X, IN HEAD AND NECK CANCER Devathri Nanayakkara Eskitis Institute for Drug Discovery Griffith University.
“Discovery Of Gene Ripple Effect Which Causes Cervical Cancer to Advance And Spread” May 19 th, 2011
Title: Dual-Modality PET and Optical Imaging of CD105 Expression in Breast Cancer Authors: Yin Zhang, Hao Hong, Yunan Yang, Jonathan Engle, Charles Theuer,
Potential therapeutic target & predictive biomarker Oncogenic IGFBP2 Sonya Song ( 宋韦 ) Beijing Shijitan Hospital Department of Oncology The Capital Medical.
Gefitinib EGFR inhibitor Non-small cell lung cancer Rash & diarrhea.
Cancer & Cancer clips how cancer grows and spreads how cancer grows and spreads.
C-Myc A Biological Paradox Ashton Butler. Table of Contents Introduction to c-Myc Normal role in the cell Relation to cancer Burkitt’s lymphoma.
Tumorigenesis and Cancer Development Pin Ling ( 凌 斌 ), Ph.D. ext 5632; References: 1.Chapter 23 Cancer in “Molecular Cell Biology”
BRG-1 in Cancer BRG-1 is an ATPase subunit of the SWI/SNF class of chromatin remodeling complexes It has been found mutated in a number of cancer cell.
MYC’s role in Osteosarcoma & Lymphoma Lauren Spoeneman.
Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings Types of Genes Associated with Cancer Cancer can be caused by mutations.
Conclusions (last lecture) Conserved structure of RNA pol II RNA pol II must navigate a chromatin template in a highly dynamic environment.
Regulating The Cell Cycle. Warm Up – The Cell Cycle The cell spends 80% of the time in _______________ and 20% of the time in ________________ What are.
Cancer Cancer- a malignant tumor; the result of abnormal cell proliferation. Regulation of Cell Division –Tumor Supressor Genes Genes that inhibit cell.
Cancer: Uncontrolled Cell Division Biology 12. Some Stats from WHO: Cancer is a leading cause of death group worldwide and accounted for 7.4 million deaths.
© 2017 SlidePlayer.com Inc. All rights reserved.