Presentation on theme: "Chemistry 910 Practical Medicinal Chemistry Dr John Carran Queen’s University Department of Chemistry."— Presentation transcript:
Chemistry 910 Practical Medicinal Chemistry Dr John Carran Queen’s University Department of Chemistry
Background In conjunction with Dale Cameron To develop a course to teach the fundamentals of medicinal chemistry and then to apply them Lecture component Practical component
Lecture component Where do drugs act How do drugs bind How are drugs metabolised/consequences How are drugs administered/consequences How are drugs tested SAR/QSAR Molecular modeling (Mike Kuiper, Melbourne, Australia) Lead compound generation/drug design Chemistry and improving activity/drug design Business/intellectual property (Angela Lyon, Parteq, Queen’s University) Process/scale up Clinical trials Case studies
Practical component Aim: To mimic an industrial lead compound selection process. Opiate analgesics. Each week for 5 weeks a series of compounds with associated data is released. Each “company” must select one compound to progress in their pipeline to lead compound designation Each company must rationalise their selection process to a Medicinal Chemistry mentor.
Mentors Dale Cameron - Migenix Corp Jack Bikker – Wyeth Research Harold Mastalertz – BMS Sheldon Hiebert – BMS Sheldon Crane – Merck Dinesh Vyas Rick Friesen
Video conferencing One per week, weeks 7-11 Skype or VSee (Free!) Each “company” has 30 minutes Questions from mentor on selection process / red herrings Teaching component Evaluations on “company” and individual members returned to me