Presentation on theme: "Education and Career Development Workshop ASV – 2011 Minneapolis Christopher C. Broder Uniformed Services University, Bethesda, MD My Science Career --"— Presentation transcript:
Education and Career Development Workshop ASV – 2011 Minneapolis Christopher C. Broder Uniformed Services University, Bethesda, MD My Science Career -- How do I Keep Moving Forward?
Streptococcus pyogenes surface proteins as receptors for human plasmin. Ph.D. Thesis (89’), University of Florida, Gainesville Vincent A. Fischetti Grewe & Geldeblom HIV Entry (1989)
HIV Entry Dimiter (Mitko) S. Dimitrov, Sc.D.,Ph.D. NCI-Frederick, Frederick, MD HIV Tropism Broder, C.C., D.S. Dimitrov, R. Blumenthal, and E.A. Berger. The Block to HIV-1 Envelope Glycoprotein-Mediated Membrane Fusion in Animal Cells Expressing Human CD4 can be Overcome by a Human Cell Component(s). Virology. 193:483-491, 1993. Think of new approaches and seek new collaborations CXCR4 CCR5
Sir Francis Bacon English author, courtier, & philosopher (1561 - 1626)... “A wise man will make more opportunities than he finds”
Oligomeric HIV-1 Envelope (gp140)--- --with Pat Earl and Bob Doms (LVD, NIAID) Broder, C.C., P.L. Earl, et al., Proc. Natl. Acad. Sci. USA. 91:11699-11703, 1994. Earl, P.L., C.C. Broder, et al., J. Virol. 68: 3015-3026, 1994. Seek out new collaborations------ it works!
Transition from postdoctoral position to academia--- (Assistant professor -1996, Uniformed Services University) Start off with the most active and successful part of your research activities- HIV tropism and entry…… HIV-1 Fusion Cofactors R01 - NIAID Analysis of Oligomeric HIV-1 Envelope Glycoproteins R21 - NIAID HIV-1 Envelope-CD4-Coreceptor Complexes as Vaccines R21 - NIAID Broadly Effective Neutralization and CTL against HIV-1 P01 - NIAID HIV-1 Fusion Cofactors R29 – NIAID, 96’ High Potency HIV-1 Broadly Cross-Reactive Neutralization U01 – NIAID, 08’ This worked: (Associate Professor - 2000, Uniformed Services University)
How about trying something “completely-different” as part of your research activities- How to make that next transition to Professor? Now what?
Reinvent some of your research endeavors…. Seek out new collaborations------ it works!
Lin-Fa Wang, Ph.D. CSIRO, Australian Animal Health Laboratory, Geelong, Australia Hendra virus 1999
“Small opportunities are often the beginning of great enterprises” Demosthenes (384 BC - 322 BC)
Nipah/Hendra Subunit Vaccines R21 - NIAID Biodefense and Emerging Infectious Diseases Research (Nipah/Hendra) U54-(RCE) - NIAID Vaccines/Therapeutics for Nipah/Hendra U01 - NIAID Nipah/Hendra Virus Entry and Assembly R01 - NIAID Nipah/Hendra Nonhuman Primate Models Therapeutics Development U01 – NIAID Biodefense and Emerging Infectious Diseases Research (bat lyssavirus) U54-(RCE) - NIAID New grounds…. This worked as well: (Professor - 2005, Uniformed Services University) Nipah/Hendra Peptide Therapeutics U01 – NIAID, 2003 Katharine Bossart, Ph.D. Human monoclonal antibody protection against Hendra virus in NHPs, ASV-2011, 40-1
Seek out new collaborations------ it still works! Keep moving forward Nonhuman Primate Models for Henipaviruses Thomas Geisbert Australian Bat Lyssavirus (ABLV) Structural Biology Program Memorial Sloan-Kettering Cancer Center, New York Dimitar B. Nikolov and Kai Xu Linfa Wang Ina Smith
A couple of take home messages---- What has worked for me………. #1 -- Seek out new collaborations-- it usually works!
A couple of take home messages---- What has worked for me………. #2 --About every 5 years --- Reinvent at least a third of your research program… Reinvent at least a third of your research program… Doing so can help you stay energized ---- but also…..
Attracts new students and young scientists with different interests and talents --- adding depth to your team. Gives you new or different research funding opportunities to pursue. Periodically reinvent your program……
Often, to achieve success in doing this, those new research directions will be related to your current productive programs
Studies on henipavirus - entry An excellent example….. Diagnostics Sero-surveillance m102.4 Immunotherapy Human mAbs Viral membrane glycoproteins HendrasG Vaccines Hendra sG
A couple of take home messages---- What has worked for me………. #3 -- Always look down the road about 2 to 3 years…. Keep an eye out for new opportunities and always be aware of the limits of your resources.
Dawn Weir USU/EID Australian bat lyssavirus – tropism ASV-2011, P1-14 Stephanie Petzing USU/EID Bat derived cells and emerging viruses ASV-2011, W39-3 Andrew Hickey, MPH, Ph.D. sG-vaccination in NHPs ASV-2011, W40-2 Deborah Steffen – USU/EID Next-Generation human mabs against henipaviruses ASV-2011, W42-8 Be aware of the limits of your resources---- to keep your lab and staff supported- especially those students that have committed themselves to your laboratory. m102.4