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Sherrie Jean, DVM Vanessa Lee, DVM Emory University School of Medicine Division of Animal Resources Prachi Sharma, DVM, PhD Yerkes National Primate Research.

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Presentation on theme: "Sherrie Jean, DVM Vanessa Lee, DVM Emory University School of Medicine Division of Animal Resources Prachi Sharma, DVM, PhD Yerkes National Primate Research."— Presentation transcript:

1 Sherrie Jean, DVM Vanessa Lee, DVM Emory University School of Medicine Division of Animal Resources Prachi Sharma, DVM, PhD Yerkes National Primate Research Center Case 45, Slide 2008-5 Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

2  Signalment › 10-11 week old male Sprague-Dawley rat (Rattus norvegicus)  Clinical history: › Surgery: left lung lobe transplant on day 0 › No prior experiments or treatments › Normal recovery and post-operative period Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

3 › Day 1 post-op: eating and drinking normally › Day 3 post-op: slightly tachypneic, lethargic and thin, but normal feces were present in the cage › Day 5 post-op: severely dyspneic, thin and had a few dehydrated fecal pellets in the cage › Day 7 post-op: Euthanized Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

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12  Lung cultures: › Heavy growth of Pseudomonas aeruginosa and Enterococcus spp.  Liver cultures: › Scant growth of alpha hemolytic Streptococci Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

13  Left lung, severe diffuse subacute suppurative pulmonary necrosis and fibrosis with intralesional bacteria  Right thoracic and abdominal wall, focal hematoma with intramuscular hemorrhage  Left thoracic wall, focal extensive subacute necrosuppurative myositis and cellulitis Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

14  Intra- or post-operative contamination  Strict aseptic technique  Highest risk of transplant rejection and/or infection  Bronchiolitis obliterans  Bruising and excessive hemorrhage. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

15  Deuse T, Schrepfer S, Reichenspurner H, Hoyt G, Fischbein MP, Robbins RC, Pelletier MP. 2007. Techniques for experimental heterotopic and orthotopic tracheal transplantations - When to use which model? Transplant Immunology. 17: 255-261.  Dishop MK, Mallory GB, White FV. 2008. Pediatric Lung Transplantation: Perspectives for the Pathologist. Pediatr Dev Pathol. Jan 29:1.  Hirschburger M, Greschus S, Kuchenbuch T, Plötz C, Obert M, Traupe H, Padberg W, Grau V. Lung transplantation in the Fischer 344-->Wistar Kyoto rat strain combination is not suitable to study bronchiolitis obliterans. 2007. J Heart Lung Transplant. Apr 26(4):390-8.  Mattner F, Fischer S, Weissbrodt H, Chaberny IF, Sohr D, Gottlieb J, Welte T, Henke-Gendo C, Gastmeier P, Strueber M. 2007. Post-operative nosocomial infections after lung and heart transplantation. J Heart Lung Transplant. 26(3):241-9.  Yamane M, Sano Y, Nagahiro I, Aoe M, Date H, Ando A, Shimizu N. 2002. Humoral immune responses during acute rejection in rat lung transplantation. Transplant Immunology. 11: 31-37. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

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