4 CR 22,4%SRB,B.,VELEBIL,P. Analysis of maternal mortality in Czech republic Česká gynekologie, 2002, 9, p
5 Maternal physiology is well prepared for hemorrhage Increase in blood volumePlasmaRBCHypercoagulable stateIncrease in plasmatic concentration of coagulating factorsThe “tourniquet” effect of uterine contractions
6 Blood supply to the pelvis Internal iliac (hypogastric) arteriesOvarian arteriesare the main vascular supply to the pelvis connected in a continuous arcade on the lateral borders of the vagina, uterus, and adnexa.
7 Blood supply to the pelvis The ovarian arteries :direct branches of the aorta beneath the renal arteries. They traverse bilaterally and retroperitoneally to enter the infundibulopelvic ligaments.
8 Blood supply to the pelvis The internal iliac arteries:retroperitoneally posterior to the ureter it divides into an anterior and posterior divisions.
9 The internal iliac arteries Anterior division5 visceral branches3 parietal branchesUterineSuperior vesicalMiddle rectalInferior rectalVaginalObturatorInferior glutealInternal pudendalAnterior part has visceral and parietal branches.
10 The internal iliac arteries Posterior divisionImportant collateral to the pelvis.IliolumbarLateral sacralSuperior glutealPosterior division includes iliolumbar, lateral sacral and superior gluteal vessels.Posterior division represents important collateral to the pelvis…
21 Women in whom these factors have been identified should be advised to deliver in a specialist obstetric unitodds ratio for PPHRisk Factor131254Proven abruptio placentaeKnown placenta praeviaMultiple pregnancyPre-eclampsia/gestational hypertension
22 The following factors, becoming apparent labour are associated with an increased risk of PPH. odds ratio for PPHRisk factor9452Delivery by emergency Caesarean sectionDelivery by elective Caesarean sectionRetained placentaMediolateral episiotomyOperative vaginal deliveryProlonged labour (>12 hours)Big baby (>4 kg)
23 Prophylactic oxytocics should be offered routinely in the management of the third stage of labour as they reduce the risk of PPH by about 60%.
24 Antenatal assessment history The existence of some of the obstetric risk factors may be known early in pregnancy from and examination.
25 Antenatal assessment anemia Detection of more than physiologic anemia of pregnancy is important, because anemia at delivery increases the likelihood of a woman requiring blood transfusion.
26 Antenatal assessment Coagulation studies May be required in the presence of congenital or acquired coagulation defects
27 Antenatal assessment Imaging investigations … are useful in the detection of placental abnormalities, with placenta previa and placenta accreta the most important identifiable risk factors for massive hemorrhage
28 Antenatal assessment Imaging investigations Conventional gray-scale assessment has a sensitivity of 93%, a specificity of 79%, and a positive predictive value of 78% in the diagnosis of placenta accreta when previa and previous cesarean scar are present.Finberg HJ, Williams JW. Placenta accreta: prospective sonographic diagnosis in patients with placenta previa and prior cesarean section. J Ultrasound Med 1992;11:
29 Antenatal assessment Imaging investigations Certain characteristics, such as the ”Swiss cheese appearance” with placenta previa, are associated with a threefold increase in mean blood loss during cesarean section.Guy GP, Peisner DB, Timor-Tritsch IE. Ultrasonographic evaluation of uteroplacental blood flow patterns of abnormally located and adherent placenta. Am J Obstet Gynecol 1990;163:
30 Antenatal assessment Imaging investigations Colour Doppler may increase the specificity to 96%, which gives a positive predictive value in high-risk patients of 87% and a negative predictive value of 95% and allows better assessment of the depth of placental myometrial or serosal invasion.Chou MM, Ho ESC, Lee YH. Prenatal diagnosis of placenta previa accreta by transabdominal color Doppler ultrasound. Ultrasound Obstet Gynecol 2000;15:
31 Antenatal assessment Imaging investigations Further imaging by MRI is recommended to assess bladder involvement in percreta and assess high-risk cases.Thorp Jr. JM, Councell RB, Sandridge DA, et al. Antepartum diagnosis of placenta previa percreta by magnetic resonance imaging. Obstet Gynecol 1992;80:
32 loss of the hypoechogenic retroplacental zone irregular uterine serosahigh vascularisation between myometrium and placentaintraplacental lacunaethinning of uterine wall
37 RESUSCITATE IV access with 14 G cannula Head down tilt Oxygen by mask, 8 litres / minTransfuseCrystalloid (eg Hartmann’s)Colloid (eg Hemacel)once 3.5 litres infused, GIVE ‘O NEG’ If no cross-matched blood available OR give uncross-matched own-group blood, as availableGive up to 1 liter Fresh Frozen Plasma and 10 units cryoprecipitate if clinically indicated
38 MONITOR / INVESTIGATE Cross-match 6 units Full blood count Clotting screenContinuous pulse / BP /ECGFoley catheter: urine outputCVP monitoringDiscuss transfer to ICU
39 STOP THE BLEEDING Exclude causes of bleeding other than uterine atony Ensure bladder emptyUterine compressionIV syntocinon 10 unitsIV ergometrine 500 mgSyntocinon infusion (30 units in 500 ml)IM Carboprost (500 mg)Surgery earlier rather than lateHysterctomy early rather than later
40 If conservative measures fail to control haemorrhage, initiate surgical haemostasis SOONER RATHER THAN LATERAcute laparotomy, direct intramyometrial injection of Carboprost (Haemabate) 0.5mgBilateral ligation of uterine arteriesBilateral ligation of internal iliac (hypogastric) arteriesHysterectomy
41 Resort to hysterectomy SOONER RATHER THAN LATER (especially in cases of placenta accreta or uterine rupture)
42 HYSTERECTOMY RATHER SOONER THAN LATER Uterine rupturePlacenta accreta
43 Whole blood frequently is used for rapid correction of volume loss because of its ready availability, but component therapy is ideal. A general practice has been to transfuse 1 unit of fresh-frozen plasma for every 3 to 4 units of red cells given to patients who are bleeding profusely
44 Genital tract lacerations Genital trauma always must be eliminated first if the uterus is firm.
45 Management of uterine atony Explore the uterine cavity.Inspect vagina and cervix for lacerations.If the cavity is empty, massage and give methylergometrine 0.2 mg, the dose can be repeated every 2 to 4 hours.Rectal 800mcg. Misoprostol is beneficial (unfortunately is not accesible)
46 Management of uterine atony During the administration of uterotonic agents, bimanual compression may control hemorrhage. The physician places his or her fist in the vagina and presses on the anterior surface of the uterus while an abdominal hand placed above the fundus presses on the posterior wall. This while the Blood for transfusion made available.
47 Retained placentaRetained placental fragments are a leading cause of early and delayed postpartum hemorrhage. Treatment is manual removal, General anesthesia with any volatile agent (1.5–2 minimum alveolar concentration (MAC)) may be necessary for uterine relaxationOn rare occasions, a retained placenta is an undiagnosed placenta accreta, and massive bleeding may occur during attempted manual removal.
48 Placenta accretaPlacenta accreta is defined as an abnormal implantation of the placenta in the uterine wall, of which there are three types:(1) accreta vera, in which the placenta adheres to the myometrium without invasion into the muscle.(2) increta, in which it invades into the myometrium.(3) percreta, in which it invades the full thickness of the uterine wall and possibly other pelvic structures, most frequently the bladder.
49 Placenta accretaIn a patient with a previous cesarean section and a placenta previa:Previous one has 14% risk of placenta accretaPrevious two has 24% risk of placenta accretaPrevious three has 44% risk of placenta accreta
50 Uterine ruptureRupture of the uterus is described as complete or incomplete and should be differentiated from dehiscence of a cesarean section scar.
51 Uterine rupture The reported incidence … For all pregnancies is 0.05% After one previous lower segment cesarean section 0.8%After two previous lower segment cesarean section is 5%All pregnancies following myomectomy may be complicated by uterine rupture.
52 Uterine ruptureComplete rupture describes a full-thickness defect of the uterine wall and serosa resulting in direct communication between the uterine cavity and the peritoneal cavity.
53 Uterine ruptureIncomplete rupture describes a defect of the uterine wall that is contained by the visceral peritoneum or broad ligament in patients with prior cesarean section.
54 Uterine ruptureDehiscence describes partial separation of the scar with minimal bleeding, with the peritoneum and fetal membranes remaining intact.
55 Management of Rupture Uterus The identification or suspicion of uterine rupture must be followed by an immediate and simultaneous response from the obstetric team.Surgery should not be delayed owing to hypovolemic shock because it may not be easily reversible until the hemorrhage is controlled.
56 Management of Rupture Uterus Upon entering the abdomen, aortic compression can be applied to decrease bleeding.Oxytocin should be administered to effect uterine contraction to assist in vessel constriction and to decrease bleeding.Hemostasis can then be achieved by ligation of the hypogastric artery, uterine artery, or ovarian arteries.
57 Management of Rupture Uterus At this point, a decision must be made to perform hysterectomy or to repair the rupture site. In most cases, hysterectomy should be performed.In selected cases, repair of the rupture can be attempted. When rupture occurs in the body of the uterus,Bladder rupture must be ruled out by clearly mobilizing and inspecting the bladder to ensure that it is intact. This avoids injury on repair of the defect as well.
58 Management of Rupture Uterus A lower segment lateral rupture can cause transection of the uterine vessels. The vessels can retract toward the pelvic side wall, and the site of bleeding must be isolated before placing clamps to avoid injury to the ureter and iliac vessels.Typically, longitudinal tears, especially those in a lateral position, should be treated by hysterectomy, whereas low transverse tears may be repaired.
59 Step by step devascularisation Uterine Artery Ligation Uterine artery ligation involves taking large purchases through the uterine wall to ligate the artery at the cervical isthmus above the bladder flap .
60 Internal iliac artery ligation The internal iliac artery is exposed by ligating and cutting the round ligament and incising the pelvic sidewall peritoneum cephalad, parallel to the infundibulopelvic ligament The ureter should be visualized and left attached to the medial peritoneal reflection to prevent compromising its blood supply.
61 Internal iliac artery ligation The hypogastric artery should be completely visualized. A blunt-tipped, right-angle clamp is gently placed around the hypogastric artery, 2.5 to 3.0 cm distal to the bifurcation of the common iliac artery. Passing the tips of the clamp from lateral to medial under the artery is crucial in preventing injuries to the underlying hypogastric vein .
67 Bleeding after hysterectomy Abdominal pelvic pressure pack
68 Intraarterial therapeutic embolisation The first applicationBenefitsEffectiveness 90%Identification of the bleeding sourceDistal vascular stopDisadvantageTime factorTechnical and personal conditionsOdegaard,E.: Intractable postpartum haemorrhage treated with selective arterial embolization.Tidsskr Nor Laegeforen.2003,123,19,s