Presentation on theme: "Petr Krepelka, 2013. Hemorrhage is the underlying causative factor in at least 25% of maternal deaths in deveveloped and developing countries."— Presentation transcript:
Petr Krepelka, 2013
Hemorrhage is the underlying causative factor in at least 25% of maternal deaths in deveveloped and developing countries
CR 22,4% SRB,B.,VELEBIL,P. Analysis of maternal mortality in Czech republic Česká gynekologie, 2002, 9, p
Maternal physiology is well prepared for hemorrhage Increase in blood volume Plasma RBC Hypercoagulable state Increase in plasmatic concentration of coagulating factors The “tourniquet” effect of uterine contractions
Blood supply to the pelvis Internal iliac (hypogastric) arteries Ovarian arteries are the main vascular supply to the pelvis connected in a continuous arcade on the lateral borders of the vagina, uterus, and adnexa.
Blood supply to the pelvis The ovarian arteries : direct branches of the aorta beneath the renal arteries. They traverse bilaterally and retroperitoneally to enter the infundibulopelvic ligaments.
Blood supply to the pelvis The internal iliac arteries: retroperitoneally posterior to the ureter it divides into an anterior and posterior divisions.
Lacerations and trauma Planned Cesarean section Episiotomy Unplanned Vaginal/cervical tear Surgical trauma Etiology of PPH
Coagulation disorders Etiology of PPH Congenital Von Willebrand's disease Acquired DIC Dilutional coagulopathy Heparin
Women in whom these factors have been identified should be advised to deliver in a specialist obstetric unit odds ratio for PPH Risk Factor Proven abruptio placentae Known placenta praevia Multiple pregnancy Pre-eclampsia/gestational hypertension
The following factors, becoming apparent labour are associated with an increased risk of PPH. odds ratio for PPH Risk factor Delivery by emergency Caesarean section Delivery by elective Caesarean section Retained placenta Mediolateral episiotomy Operative vaginal delivery Prolonged labour (>12 hours) Big baby (>4 kg)
Prophylactic oxytocics should be offered routinely in the management of the third stage of labour as they reduce the risk of PPH by about 60%.
The existence of some of the obstetric risk factors may be known early in pregnancy from and examination. Antenatal assessment history
Antenatal assessment anemia Detection of more than physiologic anemia of pregnancy is important, because anemia at delivery increases the likelihood of a woman requiring blood transfusion.
May be required in the presence of congenital or acquired coagulation defects Antenatal assessment Coagulation studies
… are useful in the detection of placental abnormalities, with placenta previa and placenta accreta the most important identifiable risk factors for massive hemorrhage Antenatal assessment Imaging investigations
Conventional gray-scale assessment has a sensitivity of 93%, a specificity of 79%, and a positive predictive value of 78% in the diagnosis of placenta accreta when previa and previous cesarean scar are present. Antenatal assessment Imaging investigations Finberg HJ, Williams JW. Placenta accreta: prospective sonographic diagnosis in patients with placenta previa and prior cesarean section. J Ultrasound Med 1992;11:
Certain characteristics, such as the ”Swiss cheese appearance” with placenta previa, are associated with a threefold increase in mean blood loss during cesarean section. Guy GP, Peisner DB, Timor-Tritsch IE. Ultrasonographic evaluation of uteroplacental blood flow patterns of abnormally located and adherent placenta. Am J Obstet Gynecol 1990;163: Antenatal assessment Imaging investigations
Colour Doppler may increase the specificity to 96%, which gives a positive predictive value in high-risk patients of 87% and a negative predictive value of 95% and allows better assessment of the depth of placental myometrial or serosal invasion. Antenatal assessment Imaging investigations Chou MM, Ho ESC, Lee YH. Prenatal diagnosis of placenta previa accreta by transabdominal color Doppler ultrasound. Ultrasound Obstet Gynecol 2000;15:28-35.
Further imaging by MRI is recommended to assess bladder involvement in percreta and assess high-risk cases. Thorp Jr. JM, Councell RB, Sandridge DA, et al. Antepartum diagnosis of placenta previa percreta by magnetic resonance imaging. Obstet Gynecol 1992;80: Antenatal assessment Imaging investigations
loss of the hypoechogenic retroplacental zone irregular uterine serosa high vascularisation between myometrium and placenta intraplacental lacunae thinning of uterine wall
Guidelines by the Scottish Executive Committee of the RCOG COMMUNICATE. RESUSCITATE. MONITOR / INVESTIGATE. STOP THE BLEEDING.
COMMUNICATE call 6 Call experienced midwife Call experienced obstetrician Call experienced anaesthesiologist Alert haematologist Alert Blood Transfusion Service Call porters for delivery of specimens / blood
RESUSCITATE IV access with 14 G cannula Head down tilt Oxygen by mask, 8 litres / min Transfuse Crystalloid (eg Hartmann’s) Colloid (eg Hemacel) once 3.5 litres infused, GIVE ‘O NEG’ If no cross- matched blood available OR give uncross-matched own-group blood, as available Give up to 1 liter Fresh Frozen Plasma and 10 units cryoprecipitate if clinically indicated
MONITOR / INVESTIGATE Cross-match 6 units Full blood count Clotting screen Continuous pulse / BP / ECG Foley catheter: urine output CVP monitoring Discuss transfer to ICU
STOP THE BLEEDING Exclude causes of bleeding other than uterine atony Ensure bladder empty Uterine compression IV syntocinon 10 units IV ergometrine 500 mg Syntocinon infusion (30 units in 500 ml) IM Carboprost (500 mg) Surgery earlier rather than late Hysterctomy early rather than later
If conservative measures fail to control haemorrhage, initiate surgical haemostasis SOONER RATHER THAN LATER I.Acute laparotomy, direct intramyometrial injection of Carboprost (Haemabate) 0.5mg II.Bilateral ligation of uterine arteries III.Bilateral ligation of internal iliac (hypogastric) arteries IV.Hysterectomy
Resort to hysterectomy SOONER RATHER THAN LATER (especially in cases of placenta accreta or uterine rupture)
HYSTERECTOMY RATHER SOONER THAN LATER Uterine rupture Placenta accreta
Whole blood frequently is used for rapid correction of volume loss because of its ready availability, but component therapy is ideal. A general practice has been to transfuse 1 unit of fresh-frozen plasma for every 3 to 4 units of red cells given to patients who are bleeding profusely
Genital tract lacerations Genital trauma always must be eliminated first if the uterus is firm.
Explore the uterine cavity. Inspect vagina and cervix for lacerations. If the cavity is empty, massage and give methylergometrine 0.2 mg, the dose can be repeated every 2 to 4 hours. Rectal 800mcg. Misoprostol is beneficial (unfortunately is not accesible) Management of uterine atony
During the administration of uterotonic agents, bimanual compression may control hemorrhage. The physician places his or her fist in the vagina and presses on the anterior surface of the uterus while an abdominal hand placed above the fundus presses on the posterior wall. This while the Blood for transfusion made available. Management of uterine atony
Retained placenta Retained placental fragments are a leading cause of early and delayed postpartum hemorrhage. Treatment is manual removal, General anesthesia with any volatile agent (1.5–2 minimum alveolar concentration (MAC)) may be necessary for uterine relaxation On rare occasions, a retained placenta is an undiagnosed placenta accreta, and massive bleeding may occur during attempted manual removal.
Placenta accreta Placenta accreta is defined as an abnormal implantation of the placenta in the uterine wall, of which there are three types: (1) accreta vera, in which the placenta adheres to the myometrium without invasion into the muscle. (2) increta, in which it invades into the myometrium. (3) percreta, in which it invades the full thickness of the uterine wall and possibly other pelvic structures, most frequently the bladder.
In a patient with a previous cesarean section and a placenta previa: Placenta accreta Previous one has 14% risk of placenta accreta Previous two has 24% risk of placenta accreta Previous three has 44% risk of placenta accreta
Uterine rupture Rupture of the uterus is described as complete or incomplete and should be differentiated from dehiscence of a cesarean section scar.
Uterine rupture The reported incidence … For all pregnancies is 0.05% After one previous lower segment cesarean section 0.8% After two previous lower segment cesarean section is 5% All pregnancies following myomectomy may be complicated by uterine rupture.
Complete rupture describes a full-thickness defect of the uterine wall and serosa resulting in direct communication between the uterine cavity and the peritoneal cavity. Uterine rupture
Incomplete rupture describes a defect of the uterine wall that is contained by the visceral peritoneum or broad ligament in patients with prior cesarean section. Uterine rupture
Dehiscence describes partial separation of the scar with minimal bleeding, with the peritoneum and fetal membranes remaining intact. Uterine rupture
The identification or suspicion of uterine rupture must be followed by an immediate and simultaneous response from the obstetric team. Surgery should not be delayed owing to hypovolemic shock because it may not be easily reversible until the hemorrhage is controlled. Management of Rupture Uterus
Upon entering the abdomen, aortic compression can be applied to decrease bleeding. Oxytocin should be administered to effect uterine contraction to assist in vessel constriction and to decrease bleeding. Hemostasis can then be achieved by ligation of the hypogastric artery, uterine artery, or ovarian arteries. Management of Rupture Uterus
At this point, a decision must be made to perform hysterectomy or to repair the rupture site. In most cases, hysterectomy should be performed. In selected cases, repair of the rupture can be attempted. When rupture occurs in the body of the uterus, Bladder rupture must be ruled out by clearly mobilizing and inspecting the bladder to ensure that it is intact. This avoids injury on repair of the defect as well. Management of Rupture Uterus
A lower segment lateral rupture can cause transection of the uterine vessels. The vessels can retract toward the pelvic side wall, and the site of bleeding must be isolated before placing clamps to avoid injury to the ureter and iliac vessels. Typically, longitudinal tears, especially those in a lateral position, should be treated by hysterectomy, whereas low transverse tears may be repaired. Management of Rupture Uterus
Step by step devascularisation Uterine Artery Ligation Uterine artery ligation involves taking large purchases through the uterine wall to ligate the artery at the cervical isthmus above the bladder flap.
Internal iliac artery ligation The internal iliac artery is exposed by ligating and cutting the round ligament and incising the pelvic sidewall peritoneum cephalad, parallel to the infundibulopelvic ligament The ureter should be visualized and left attached to the medial peritoneal reflection to prevent compromising its blood supply.
The hypogastric artery should be completely visualized. A blunt-tipped, right-angle clamp is gently placed around the hypogastric artery, 2.5 to 3.0 cm distal to the bifurcation of the common iliac artery. Passing the tips of the clamp from lateral to medial under the artery is crucial in preventing injuries to the underlying hypogastric vein. Internal iliac artery ligation
Abdominal pelvic pressure pack Bleeding after hysterectomy
Intraarterial therapeutic embolisation The first application Benefits –Effectiveness 90% –Identification of the bleeding source –Distal vascular stop Disadvantage –Time factor –Technical and personal conditions Odegaard,E.: Intractable postpartum haemorrhage treated with selective arterial embolization. Tidsskr Nor Laegeforen.2003,123,19,s