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Teaching Liver cirrhosis with varices. Discussion  Approximately half of patients with cirrhosis have esophageal varices  One-third of all patients.

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Presentation on theme: "Teaching Liver cirrhosis with varices. Discussion  Approximately half of patients with cirrhosis have esophageal varices  One-third of all patients."— Presentation transcript:

1 Teaching Liver cirrhosis with varices

2 Discussion  Approximately half of patients with cirrhosis have esophageal varices  One-third of all patients with varices will develop variceal hemorrhage  a major cause of morbidity and mortality in patients with cirrhosis

3 Discussion  Their presence correlates with the severity of liver disease  40% of Child A patients  85% of Child C patients

4 Discussion  Although bleeding from esophageal varices ceases spontaneously in up to 40% of patients  It is associated with a mortality of at least 20% at 6 weeks

5 Discussion  Gastric varices are less prevalent than esophageal varices  5%-33% of patients with portal hypertension  incidence of bleeding of about 25% in 2 years

6 Discussion  Screening esophagogastroduodenoscopy (EGD) for the diagnosis of esophageal and gastric varices is recommended when the diagnosis of cirrhosis is made

7 Discussion  General principles of the management of variceal hemorrhage  Prediction of patients at risk  Treatment of an active bleed  Prevention of rebleeding

8 Prediction of patients at risk  PREDICTIVE FACTORS  Location of varices  Size of varices  Appearance of varices  Clinical features of the patient  Variceal pressure

9 Prediction of patients at risk

10 Treatment of an active bleed  Acute GI hemorrhage in a patient with cirrhosis is an emergency that requires prompt attention with intravascular volume support and blood transfusions  Being careful to maintain a hemoglobin of 8 g/dL

11 Treatment of an active bleed  Short-term (maximum 7 days) antibiotic prophylaxis should be instituted in any patient with cirrhosis and GI hemorrhage

12 Treatment of an active bleed  Pharmacological therapy (somatostatin or its analogues octreotide and vapreotide; terlipressin)  initiated as soon as variceal hemorrhage is suspected and continued for 3-5 days after diagnosis is confirmed  Terlipressin: initial dose of 2 mg IV Q4H, titrated down to 1 mg IV Q4H once hemorrhage is controlled

13 Treatment of an active bleed  EGD, performed within 12 hours, should be used to make the diagnosis and to treat variceal hemorrhage, either with EVL or sclerotherapy

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15 Treatment of an active bleed  Transjugular intrahepatic portosystemic shunting (TIPS) is indicated in patients in whom hemorrhage from esophageal varices cannot be controlled or in whom bleeding recurs despite combined pharmacological and endoscopic therapy

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17 Treatment of an active bleed  Balloon tamponade should be used as a temporizing measure (maximum 24 hours) in patients with uncontrollable bleeding for whom a more definitive therapy (eg, TIPS or endoscopic therapy) is planned

18 Prevention of rebleeding  Patients with cirrhosis who survive an episode of active variceal hemorrhage should receive therapy to prevent recurrence of variceal hemorrhage (secondary prophylaxis)

19 Prevention of rebleeding  Combination of nonselective-blockers plus EVL is the best option for secondary prophylaxis of variceal hemorrhage

20 Prevention of rebleeding  TIPS should be considered in patients who are Child A or B who experience recurrent variceal hemorrhage despite combination pharmacological and endoscopic therapy.

21 Prevention of rebleeding  Patients who are otherwise transplant candidates should be referred to a transplant center for evaluation

22 Thank you for your attention!


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