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Automated Toxicology Screening System using Artificial Intelligence based Self Learning Imaging System with Pattern Identification Dr. Aparna Joshi Chief.

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Presentation on theme: "Automated Toxicology Screening System using Artificial Intelligence based Self Learning Imaging System with Pattern Identification Dr. Aparna Joshi Chief."— Presentation transcript:

1 Automated Toxicology Screening System using Artificial Intelligence based Self Learning Imaging System with Pattern Identification Dr. Aparna Joshi Chief Medical Officer, Optra Systems (www.optrasystems.com)

2 WHY? Screening Strategies for Histopathological evaluation in Toxicology - One of the major problems facing the research industry

3 Automated Toxicology Screening System  Design based on histological morphology of various tissues  In accordance with pathological lesions  To flag abnormal patterns in high throughput scenario  To “Learn on the Fly” without programmatic changes  To dynamically adapt to various boundary conditions  Personalizable and Customizable  Acceptability on variety of image acquisition devices  Can qualify images as Accept / Reject prior to screening “An artificial intelligence based self learning imaging system”

4 OptraAssays ™ (Image analysis libraries for histopathology in toxicological analysis)  Angiogenesis.dll  Hemorrhage.dll  Pan_Morphometry.dll  Cellularity assessment.dll  Necrosis.dll  Infarction.dll  Fibrosis.dll  Mitoses.dll  Micrometastasis.dll  Adenomyosis.dll

5 Subcutaneous implantation of a cotton thread in the dorsum of rabbits (Oryctolagus cuniculus ) induced granulation tissue formation with angiogenesis. Automated detection of same. Red blood cells Endothelial cells Intravascular lumen Pre Image Analysis Post Image Analysis

6 Subcutaneous implantation of a cotton thread in the dorsum of rabbits (Oryctolagus cuniculus ) induced granulation tissue formation with angiogenesis. Automated detection of same. Red blood cells Intravascular lumen Endothelial cells Pre Image AnalysisPost Image Analysis

7 OptraAssays ™ (Image analysis libraries for histopathology in toxicological analysis)  Angiogenesis.dll  Hemorrhage.dll  Pan_Morphometry.dll  Cellularity assessment.dll  Necrosis.dll  Infarction.dll  Fibrosis.dll  Mitoses.dll  Micrometastasis.dll  Adenomyosis.dll

8 Automated detection of intratumoral hemorrhage in neuroblastoma Pre Image AnalysisPost Image Analysis

9 Automated detection of intratumoral hemorrhage in neuroblastoma Pre Image AnalysisPost Image Analysis

10 OptraAssays ™ (Image analysis libraries for histopathology in toxicological analysis)  Angiogenesis.dll  Hemorrhage.dll  Pan_Morphometry.dll  Cellularity assessment.dll  Necrosis.dll  Infarction.dll  Fibrosis.dll  Mitoses.dll  Micrometastasis.dll  Adenomyosis.dll

11 Automated Morphometry of Pancreatic Islet cells Pre Image AnalysisPost Image Analysis

12 Automated Morphometry of Pancreatic Islet cells Cellularity: Normocellular Area/Size : Normal Fibrosis: Absent Pre Image AnalysisPost Image Analysis

13 Automated Thyroid Histopathology ColloidFollicular Epithelial CellsLymphocytes vs Epithelial Cells Pre Image AnalysisPost Image Analysis

14 Automated Thyroid Histopathology Lymphocytes vs Epithelial Cells ColloidFollicular Epithelial Cells Pre Image AnalysisPost Image Analysis

15 OptraAssays ™ (Image analysis libraries for histopathology in toxicological analysis)  Angiogenesis.dll  Hemorrhage.dll  Pan_Morphometry.dll  Cellularity assessment.dll  Necrosis.dll  Infarction.dll  Fibrosis.dll  Mitoses.dll  Micrometastasis.dll  Adenomyosis.dll

16 Automated detection of Necrosis Pre Image AnalysisPost Image Analysis

17 Automated detection of Necrosis Pre Image AnalysisPost Image Analysis

18 OptraAssays ™ (Image analysis libraries for histopathology in toxicological analysis)  Angiogenesis.dll  Hemorrhage.dll  Pan_Morphometry.dll  Cellularity assessment.dll  Necrosis.dll  Adenomyosis.dll  Infarction.dll  Fibrosis.dll  Mitoses.dll  Micrometastasis.dll

19 Female rhesus monkeys (Macaca mulatta) were ovariectomized and treated with subcutaneous implants, each containing 200 mg estradiol. Adenomyosis at necropsy Automated detection of Adenomyosis Pre Image AnalysisPost Image Analysis

20 Female rhesus monkeys (Macaca mulatta) were ovariectomized and treated with subcutaneous implants, each containing 200 mg estradiol. Adenomyosis at necropsy Automated detection of Adenomyosis Pre Image AnalysisPost Image Analysis

21 OptraAssays ™ (Image analysis libraries for histopathology in toxicological analysis)  Angiogenesis.dll  Hemorrhage.dll  Pan_Morphometry.dll  Cellularity assessment.dll  Necrosis.dll  Adenomyosis.dll  Infarction.dll  Fibrosis.dll  Mitoses.dll  Micrometastasis.dll

22 Summary  Angiogenesis.dll  Hemorrhage.dll  Pan_Morphometry.dll  Cellularity assessment.dll  Necrosis.dll  Infarction.dll  Fibrosis.dll  Mitoses.dll  Micrometastasis.dll  Adenomyosis.dll Automated Toxicology Screening System OptraAssays™

23 Acknowledgement Development team at Optra Systems, India


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