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Lecture – 3 Dr. Zahoor Ali Shaikh 1.  What is Anemia? Anemia means - Decreased hemoglobin - Decreased RBC count - Decreased Hematocrit [PCV] Therefore,

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Presentation on theme: "Lecture – 3 Dr. Zahoor Ali Shaikh 1.  What is Anemia? Anemia means - Decreased hemoglobin - Decreased RBC count - Decreased Hematocrit [PCV] Therefore,"— Presentation transcript:

1 Lecture – 3 Dr. Zahoor Ali Shaikh 1

2  What is Anemia? Anemia means - Decreased hemoglobin - Decreased RBC count - Decreased Hematocrit [PCV] Therefore, decreased O 2 carrying capacity of blood. 2

3 Nutritional Anemia It is caused by dietary deficiency of factors needed for Erythropoiesis. 1. Dietary Deficiency of Iron Iron deficiency anemia is called microcytic hypochromic anemia as RBC is small with less Hemoglobin. 3

4 2. Megloblastic Anemia It is due to deficiency of vitamin B12 or folic acid. Vitamin B12 is essential for normal RBC maturation. Vitamin B12 deficiency leads to Megloblastic Anemia [RBC size is large]. 4

5 Pernicious Anemia - It is due to deficiency of Intrinsic factor produced by Parietal cells of stomach. - Intrinsic factor is necessary for absorption of Vitamin B12. - Vitamin B12 is absorbed from intestinal tract [terminal ileum] when Vitamin B12 is bound to intrinsic factor. - Pernicious Anemia is megloblastic anemia. 5

6 3. Aplastic Anemia It is caused by failure of bone marrow to produce RBC even though all necessary nutrients for Erythropoiesis are available. Causes of Aplastic Anemia -Excessive exposure to X-ray -Exposure to radiation, e.g. bomb blast -Chemotherapy for Cancer -Drugs 6

7 4. Hemolytic Anemia It is caused by rupture [breakdown] of RBC. Causes of Hemolytic Anemia -Malaria -Sickle Cell Anemia [Hemoglobin β chain is defective where valine replaces glutamate at position 6 in this amino acid chain].RBC is sickle shaped -Mismatched blood transfusion -Drugs 7

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9 5. Renal Anemia Anemia in Renal [kidney] disease is due to decreased Erythropoietin secretion from the kidney. It leads to decreased RBC production. 9

10 6.Hemorrhagic Anemia - It is caused by losing a lot of blood. - Acute Loss of blood e.g. car accident. - Chronic Loss of blood e.g. bleeding peptic ulcer, excessive menstrual flow. 10

11  How to diagnose microcytic hypochromic anemia [iron deficiency] and macrocytic [megloblastic] which is vitamin B12 deficiency anemia? We see Hemoglobin, RBC, PCV [Hematocrit] MCV [Mean Cell Volume] MCH [Mean Concentration of Hemoglobin] MCHC [Mean Cell Hemoglobin Concentration] 11

12 We will define MCV, MCH, MCHC. MCV – it is the volume of average RBC - Normal MCV = 90 fL or 90 μ 3 [MCV > 95 fL are called macrocyte] [MCV < 80 fL are called microcyte] MCH – it is mean concentration of Hemoglobin in each RBC. - Normal MCH = 30 picogram [pg] MCHC – it is hemoglobin present per 100ml of RBC. - Normal MCHC = 30 gram/100ml of RBC 12

13 Microcytic Hypochromic Anemia Or Iron Deficiency Anemia In iron deficiency anemia Hemoglobin RBC Hematocrit MCV MCH MCHC 13

14 Macrocytic [Megloblastic] Anemia Vitamin B12 or folic acid deficiency Hemoglobin RBC Hematocrit MCV MCH Normal MCHC Normal It is called Macrocytic Normochromic Anemia. 14

15 15 NORMAL VALUE & FORMULA FOR CALCULATION OF MCV, MCH, MCHC

16 A patient came with a history of fatigue, weakness. His blood analysis was done RBC count 3.6 × 10 6 / mm 3 Hb concentration 7.0 g / 100ml PCV 25% MCV 69.4 fL [femtoliter] Normal 90 fL MCH 19.4 pg [picogram] Normal 30 pg MCHC 28 g / dl Normal 34 g/dl  What is Diagnosis ? Microcytic Hypochromic Anemia [Iron deficiency Anemia] 16

17 Polycythemia is characterized by increased number of RBC and increased Hematocrit. Types of Polycythemia 1. Primary Polycythemia 2. Secondary Polycythemia 17

18 Primary Polycythemia is tumor like condition of bone marrow, where, there is increased production of RBC. RBC count may reach 11 million/mm 3 (normal is 5 million cells/mm 3 ). Hematocrit may be 70-80% [normal 42-45%]. 18

19 Side Effects - As there is increased viscosity of blood, it causes blood to flow very slowly, which may reduce O 2 delivery to tissues. - Increased viscosity causes increased peripheral resistance which may cause increased blood pressure. 19

20 Secondary Polycythemia is due to decreased O 2 delivery to the tissues. It occurs in people living at high altitude as O 2 available in the air is less. It occurs in people with chronic lung disease called Cardiac [heart] failure due to decreased O 2 delivery to the tissues. RBC count may be 6 to 8 million/mm 3. 20

21 Relative Polycythemia occurs when there is body fluid loss e.g. diarrhea, heavy sweating. There is body fluid loss, but no loss of erythrocytes. This is not true Polycythemia as RBC are not increased, but only plasma volume is decreased. As RBC are concentrated in small plasma volume, this condition is called Relative Polycythemia. 21

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23 Effect of Anemia In Anemia, blood viscosity is decreased to 1.5 times of water [normal viscosity 2.5 – 3 times of water]. Therefore, there is decreased peripheral resistance, it causes increased blood flow and increased venous return to heart, therefore, increased cardiac output. Anemia causes hypoxia [decrease O 2 delivery to tissues], therefore, increased cardiac output. 23

24 Effect of Polycythemia In Polycythemia, there is increased viscosity, therefore, blood flow is sluggish [slow]. Increased viscosity leads to increased peripheral resistance, therefore, increased blood pressure can occur [in 1/3 rd of polycythemic people]. 24

25 What is Anemia ? Types of Anemia Difference between Microcytic Hypochromic and Macrocytic Normochromic Anemia Normal Values for RBC, Hb, HCT [PCV], MCV, MCH, MCHC Polycythemia Definition Difference between Primary Secondary Polycythemia Effect of Anemia and Polycythemia on body 25

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