Presentation on theme: "ANEMIA DEFINITION & CLASSIFICATION"— Presentation transcript:
1ANEMIA DEFINITION & CLASSIFICATION Maj Gen (R) Masood AnwarProfessor of Haematology
2DEFINITION Functions of blood Composition of blood Transport of nutrientsTransport of gasesHaemostasisDefenceComposition of bloodCells (RBC, WBC, Platelets)Plasma (Colloids, Crystalloids, Water)
3DEFINITION PYSIOLOGICAL DEFINITION Decrease in oxygen carrying capacity of blood.ANALYTICAL (PATHOLOGICAL) DEFINITIONReduction in total circulating red cell massReduction in Haemoglobin concentration and/or Haematocrit
4RED BLOOD CELLSThese are blood cells produced in the bone marrow from a pleuripotent haemopoietic stem cell by processes of division, differentiation and maturation and released in the circulation to function mainly to transport oxygen from lungs to other tissues of the body.
6MEASUREMENT OF RED BLOOD CELL MASS AND INDICES Haemoglobin (Hb)Haematocrit (Hct)[Packed Cell Volume (PCV)]Total Red Blood Cell Count (TRBC)Mean Cell Volume (MCV)Mean Cell Haemoglobin (MCH)Mean Cell Haemoglobin Concentration (MCHC)Red Cell Distribution Width (RDW)
8CLASSIFICATION MORPHOLOGICAL CLASSIFICATION Based on appearance of RBC under the microscope OR red blood cell indicesPATHOLOGICAL CLASSIFICATIONBased on abnormality of anatomical, biochemical or physiological abnormalityETIOLOGICAL CLASSIFICATIONBased on specific causative process/agent