Presentation on theme: "ANEMIA DEFINITION & CLASSIFICATION"— Presentation transcript:
1 ANEMIA DEFINITION & CLASSIFICATION Maj Gen (R) Masood AnwarProfessor of Haematology
2 DEFINITION Functions of blood Composition of blood Transport of nutrientsTransport of gasesHaemostasisDefenceComposition of bloodCells (RBC, WBC, Platelets)Plasma (Colloids, Crystalloids, Water)
3 DEFINITION PYSIOLOGICAL DEFINITION Decrease in oxygen carrying capacity of blood.ANALYTICAL (PATHOLOGICAL) DEFINITIONReduction in total circulating red cell massReduction in Haemoglobin concentration and/or Haematocrit
4 RED BLOOD CELLSThese are blood cells produced in the bone marrow from a pleuripotent haemopoietic stem cell by processes of division, differentiation and maturation and released in the circulation to function mainly to transport oxygen from lungs to other tissues of the body.
6 MEASUREMENT OF RED BLOOD CELL MASS AND INDICES Haemoglobin (Hb)Haematocrit (Hct)[Packed Cell Volume (PCV)]Total Red Blood Cell Count (TRBC)Mean Cell Volume (MCV)Mean Cell Haemoglobin (MCH)Mean Cell Haemoglobin Concentration (MCHC)Red Cell Distribution Width (RDW)
7 NORMAL VALUES PARAMETER ADULT MALE ADULT FEMALE Hb 13-17 g/dl TRBCX 1012/lX 1012/lHct/PCV40-54%/ l/l36-49%/ l/lMCV76-96 flMCH27-32 pgMCHCg/dl
8 CLASSIFICATION MORPHOLOGICAL CLASSIFICATION Based on appearance of RBC under the microscope OR red blood cell indicesPATHOLOGICAL CLASSIFICATIONBased on abnormality of anatomical, biochemical or physiological abnormalityETIOLOGICAL CLASSIFICATIONBased on specific causative process/agent