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Visualization of Clinical Trials CT-eXplorer Maleh Hernandez Chris Bennett Lucas Panjer.

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Presentation on theme: "Visualization of Clinical Trials CT-eXplorer Maleh Hernandez Chris Bennett Lucas Panjer."— Presentation transcript:

1 Visualization of Clinical Trials CT-eXplorer Maleh Hernandez Chris Bennett Lucas Panjer

2 Outline Motivation Problem Solution Implementation Milestones Challenges

3 Motivation Millions of dollars are spent each year conducting cinical trials, but… Analyzing results takes up to two years There is no standard way to compare multiple trials A good visualization tool would allow rapid ‘literature review’

4 Problem Trial Designers need to: Locate, retrieve, compare, and contrast trials and subsets of data Discover errors and problems in data Identify opportunities for new trials

5 Users and Data set Clinical Trial Safety Outcomes Efficacy Outcomes Co-morbidities Qualifying conditions Past Interventions Age Trial Designer Treatment

6 Scenario Pat is designing a trial for Mother to Child Transmission of HIV Considers using Zidovudine and Nevirapine delivered together (treatment) Interested in early pregnancy testing of African populations (qualifying conditions) Must ensure no current immunotherapy (eligibility) Needs to understand risks (outcomes) She uses dynamic queries and linked views to explore data

7 Proposed Solution

8 Absolute neutrophil count (cells/mm 3 ) > Gestational Age (weeks) Platelet count (cells/mm 3 ) > Serum Creatinine (mh/dL) > Trial Hemoglobinaemia concentration (g/dL) > Guay Connor Davis Lallemant Qualifying Conditions    

9 Other eligibility criteria

10 During Pregnancy B B C B A During Labor A C A D Post partum Trial Name Guay Connor Davis Nevirapine Zidovudine Placebo Didanosine Total Size By Arm Lallemant B A       Interventions

11 A B B C B A A C A D Trial Name Guay Connor Dabis Infant Anemia Maternal mortality Infant Mortality Infant Neutropenia Maternal neutropia Maternal anemia Safety Outcomes Efficacy Outcomes Month Week Infant HIV infected Birth Primary Outcomes Infant Mortality Infant Neutropenia Maternal neutropia Maternal anemia Infant HIV infected Weeks Infant Anemia Maternal anemia Infant Anemia Lallemant B Infant Anemia Infant HIV infectedInfant Anemia Infant HIV infectedInfant Anemia Infant Neutropenia Maternal neutropia Maternal anemiaInfant Anemia label             Outcomes

12 Implementation details

13 Selected Milestones October 28 – Finalized Design November 10 – Separate display-only views complete (aggresive) November 30 – Dynamic queries and linking complete December 6 – Testing and evaluation complete See proposal document for details…

14 Challenges Gathering and Structuring Data Technical challenges Linking views InfoViz success rate Timeframe

15 Thank you! Questions? How can we improve on this? More info at:


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