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↓production 2 of 3 sign.granulocyte<500/ul,plt,20K/ul.corected retic<1% Sever aplastic anemia gra<200/ul
Hematologic findings Normo-macrocytic anemia Aniso-poikilo(oval-macrocyte) RDW Leukopenia,thrombocytopenia ▲fe,co,folate normal BM:fat tissue,fibrosis,↓cellularity,
BM biopsy hypocellular,increased fat spaces
signs Sever pancytopenia or chronic phase Bleeding (40%),infection,no splenomegaly,lymphodenophaty
etyology -Heriditary -non beriditary Idiopatic in 70% Drugs(anti neoplastic busulfan,oratan,) & chemical agent 11-20%(irradiation
"name": "etyology -Heriditary -non beriditary Idiopatic in 70% Drugs(anti neoplastic busulfan,oratan,) & chemical agent 11-20%(irradiation
Mechanism of dx Direct(immunologic,drugs,irradiatin,viruses Activation tcyt
prognosis Degree of pancytopenia Sex age
<50y BMT Anti lym-globolin,coricosteroids antibiotic
chol Dose dependent(reversable):↓retic,↓erytheroid cells Dose independent(3-5m after last )
Aplastic anemia related other disease Infection(HIV,B19,hepatitis) PNH Pregnancy immunologicDx(RA,lopous,MS,tyroid immune dx)
hereditary Heriditary defect in BM -fancony anemia Autosomal Ressesive,pancytopenia,sever in 8y,normo-macrocytic ▲HBF,ag I,NM hypo cellular,hypo pigmentasion,short,hypogonadism,deformit in finger,radius,).microcephaly,deformity (heart,kidny)
Chromosal breaking & rearranging Mitomycin C,deeppoxy butan, Defect in FANCA in70% In chromosal stability Survival 19y15% neoplasia -amegakaryocytic thrombocytopenia defect in c-MPL Dyskeratosis maternal,shoakhman- diamonad(pancras defect,nutropenia) syndrom shift to AA
-pure red cell aplasia non lasting aplastic crisis B19 Erytheroblastopenia in infants:1-3y.viruses Diamond-blackfan.rare,in 1y,▲HbF,↓BFU- E,CFU-E▲apoptosis 75%cortico steroids,
Sidroblasic anemia 20-60% e-precursore sidroblasts Ring sidroblast Defect in heme synthesis Erytheroid hyper plasia Normochrom-hypocromia ▲sfe,↓TIBC,▲saturation degree
Hereditary SA X-linked(↓δALAS-2 ↓link to B6 or ▲degradiation enzymto mitoconderial proase,autosomal dominant,ressesive) Mitoconderialdeletion(pyerson syndrom (pancras defect,BM cells vaculization,ring sidroblast
Acquired SA Idiophatic(15% sidroblast ring) Secondary:isonisid.sicloserin.pirazin amid Pb(ALA synthase,ALA dehydratase,hem syntetase) Ala,coproporfirin increase.chloram with inhibition protein synthase.Zn.Cu Penicilin amin Zn chelator Ethanol reversable SA B6 deficiency with malnutrition (neuropaty,skin irritation) B6 deficiency
Aplastic anemia. Definition Panctopenia with hypocellularity A rare and serious condition, aplastic anemia can develop at any age, though it's most common.
Normocytic Anemia Dr. Fatin Al-Sayes, MD, MSc, MRCPath Consultant Hematology / Assistant Professor King Abdulaziz University Hospital.
Aplastic Anemia Failure of the bone marrow percursors to produce mature cells. Characterized by hypocellular marrow and pancytopenia. Etiology: Acquired:
Bone Marrow Aplasia Objective 3: Discuss the components and causes of bone marrow aplasia.
APLASTIC AND HYPOPLASTIC ANEMIAS Waggas Elaas. APLASTIC ANEMIA Aplastic anemia is a severe, life threatening syndrome in which production of erythrocytes,
APLASTIC ANEMIA Divisi Hemato-Onkologi Bagian Ilmu Kesehatan Anak Universitas Sumatera Utara.
Aplastic Anemia Rakesh Biswas
Normocytic Normochromic Anemias
Approach to Anemia - Summary
AN APPROACH TO THE ANEMIC PATIENT Martin H. Ellis MD Meir Hospital 2007.
Week 2: Hemolytic Anemia
APLASTIC AND HYPOPLASTIC ANEMIAS
APLASTIC ANEMIA BY- DR. ABHISHEK SINGH MD ASSTT. PROFESSOR DEPTT. OF MEDICINE.
Date of download: 6/22/2016 From: Acquired Aplastic Anemia Ann Intern Med. 2002;136(7): doi: / Venn diagram.
Acute leukemia Mohammed Al-matrafi.
Nada Mohamed Ahmed, MD, MT (ASCP)i. Objectives Intoduction Definition Classification Intravascular &extra vascular hemolysis Signs of hemolytic anemias.
Maj Gen (R) Masood Anwar. Bone marrow failure syndromes can be defined as a group of diseases in which occurs failure on the part of bone marrow to produce.
Morbidity & Mortality: 2012 Chart Book on Cardiovascular, Lung, and Blood Diseases National Heart, Lung, and Blood Institute February, 2012.
NURSING CARE OF THE CHILD WITH A HEMATOLOGIC ALTERATION.
Approach to Anemia Sadie T. Velásquez, M.D.. Objectives.
Iron deficiency anemia Tsila Zuckerman. Anemia Definition : Decreased RBC mass and HB concentration Anemia is a result of imbalance between between RBC.
Blood Types A B AB O. Four major types of blood. A, B, AB, and O. Inherited from parents. Determined by presence or absence of an ANTIGEN on the surface.
Chemotherapy/ Biotherapy for Hematology Disease Processes.
Bone Marrow Failure/ Aplastic Anemia
Laboratory evaluation of erythrocyte RBC Haemoglobin Packed cell volume MCV MCH MCHC RDW Reticulocyte Blood film Quantitative description of erythropoiesis.
Platelets. Fig Hemostasis the process by which the bleeding is stopped from broken vessels. steps involved: Vascular spasm. Platelets plug formation.
Alterations of Erythrocyte Function
APLASTIC ANEMIA. Aplastic Anemia Aplastic anemia is a bone marrow failure syndrome characterized by peripheral pancytopenia and marrow hypoplasia. Bone.
By Fatin Al-Sayes MD, MSc, FRCPath Consultant Hematology Assistant Professor.
Aplastic Anemia Andrew J Avery A.M. Report 04/30/10.
CLINICAL PRESENTATION OF ANEMIA Anemia is most often recognized by abnormal screening laboratory tests. The gradual onset of anemia, particularly in.
Thyroid gland The normal circulating thyroid hormones are Thyroxine T4 (90%),Triiodothyronine T3 (9%) and rT3 (1%). Reverse T3 (rT3) is biologically inactive.
DR. HANA OMER. Causes and principals of cell injury. Mechanisms of cell injury Definition and causes of HYPERPLASIA, HYPERTROPHY, ATROPHY, METAPLASIA,
MLAB Hematology Keri Brophy-Martinez Unit 7: Anemia.
Acquired Aplastic Anaemia – Trends in treatment and Bone Marrow Transplantation Vikas Gupta, MD Blood and Marrow Transplant Program Princess Margaret Hospital.
MLAB Hematology Keri Brophy-Martinez Chapter 9: Iron Metabolism and Hypochromic Anemias.
Immunodeficiency K.J. Goodrum Origins of Immunodeficiency Primary or Congenital –Inherited genetic defects in immune cell development or function,
Anemia. Classification of anemia 1.Anemia due to blood loss (Posthemorrhagic): - Acute - Chronic 2. Anemia due to impaired blood formation: - Iron deficiency.
ANEMIA DEFINITION & CLASSIFICATION
Hemolytic anemia Excessive destruction of red cells Acute Hemolytic anemia Chronic Hemolytic anemia Congenita l Acquired : Immune Non-immune.
Cancer Education Day Pediatric Hematology May 13, 2016 Dr. Mohammad Jarrar.
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Hemolytic anemias Hemolytic anemias 1. Objectives 1.Define Haemolytic anaemias and their classification. 2.Define the terms "intravascular hemolysis"
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