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How does PROMIS compare to other HRQOL measures? Ron D. Hays, Ph.D. UCLA, Los Angeles, CA Symposium 1077: Measurement Tools to Enhance Health- Related.

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Presentation on theme: "How does PROMIS compare to other HRQOL measures? Ron D. Hays, Ph.D. UCLA, Los Angeles, CA Symposium 1077: Measurement Tools to Enhance Health- Related."— Presentation transcript:

1 How does PROMIS compare to other HRQOL measures? Ron D. Hays, Ph.D. UCLA, Los Angeles, CA Symposium 1077: Measurement Tools to Enhance Health- Related Quality of Life Research: The Patient-Reported Outcomes Measurement Information System (PROMIS)

2 Advantages of Short-Forms Developed from Item Banks Select a set of items that are matched to the severity level of the target population. All scales built from the same item bank are linked on a common metric.

3 no depression mild depression moderate depression severe depression extreme depression    Depressive Symptoms Item Bank Item 1 Item 2 Item 3 Item 4 Item 5 Item 6 Item 7 Item 8 Item 9 Item n   Depression Symptoms Form A Depression Symptoms Form B Depressive Symptoms Form C

4 Computerized Adaptive Testing (CAT) CAT selects each question to be administered based on a person’s response to previously administered questions. By iteratively estimating a person’s standing on the domain (e.g., depressive symptoms) and administering the most informative items, the maximum possible level of precision can be obtained with the fewest number of questions.

5 Example of Short Forms and CAT Compare results from respondents based on two different depressive symptoms short forms, CAT, and full item bank. Do they produce equivalent results? Implications for use of alternate PROMIS short forms in clinical trials.

6 Respondent (n = 752) Characteristics Responded to the 28 items in the PROMIS depressive symptoms item bank –Mean age = 51 (18-93 range) –52% female –78% white, 10% Hispanic, 10% black –22% high school graduate or less

7 Ordering of 28 Depressive Symptom items, Least to Most Severe (Short Form A and B items indicated with superscript) #Item# 1I felt sad b 15I felt guilty 2I felt disappointed in myself a 16I felt that I was not as good as other people 3I felt unhappy b 17I felt that nothing was interesting b 4I felt discouraged about the future a 18I felt like a failure a 5I felt pessimistic19I felt that my life was empty b 6I felt emotionally exhausted20I felt that I was not needed 7I had trouble feeing close to people21I felt that I had nothing to look forward to a 8I felt lonely22I felt upset for no reason 9I felt depressed23I felt helpless b 10I found that things in my life were overwhelming a 24I felt that nothing could cheer me up a 11I had trouble making decisions25I felt hopeless b 12I felt ignored by people26I felt worthless a 13I withdrew from other people27I felt that I wanted to give up on everything b 14I felt that I was to blame for things28I felt I had no reason for living a

8 Form A Items #In the past 7 days…Mean% Never 2I felt disappointed in myself I felt discouraged about the future I found that things in my life were overwhelming I felt like a failure I felt that I had nothing to look forward to I felt that nothing could cheer me up I felt worthless I felt I had no reason for living Response Options: Never, Rarely, Sometimes, Often, Always

9 Form B Items #In the past 7 days…Mean% Never 1I felt sad I felt unhappy I felt depressed I felt that nothing was interesting I felt that my life was empty I felt helpless I felt hopeless I felt I wanted to give up on everything Response Options: Never, Rarely, Sometimes, Often, Always

10 Mean, Minimum and Maximum Scores Form A (8 items) Form B (8 items) CAT (8 items) Full Bank (28 items) Mean49 Minimum Maximum

11 Correlations Among Forms Form AForm BCAT Form A Form B CAT Bank

12 Scale Score Comparisons: Short Forms, CAT (8 items) and Full-Bank (28 Items)

13 Correlation of Depressive Symptoms Bank with CESD

14 Fatigue Experience and Impact 95-item bank Legacy Instruments SF-36 Vitality Scale (4 items) FACIT-Fatigue Scale (13 items)

15 4-item SF36/Vitality 4-item CAT 13-item FACIT-Fatigue 13-item CAT 98-item Bank No Fatigue Severe Fatigue SE=0.32 (r=0.90) SE=0.22 (r=0.95) Comparison of Measurement Precision Full-length Item Bank vs. Legacy vs. CAT vs. Short-form Standard Error

16 PROMIS Fatigue Short Form Garcia SF et al, J Clin Onc, © 2007 Reprinted with permission of the PROMIS Health Organization and the PROMIS Cooperative Group

17 7-item Short-form 7-item CAT 98-item Bank No Fatigue Severe Fatigue SE=0.32 (r=0.90) SE=0.22 (r=0.95) Comparison of Measurement Precision Full-length Item Bank vs. Legacy vs. CAT vs. Short-form Standard Error

18 SE = 3.2 rel = 0.90 SE = 2.2 rel = PROMIS CAT 10 items PROMIS 10 items SF items Physical Functioning SF PROMIS CAT PROMIS static 10

19 Questions?

20 Never Rarely Some times Often Always In the past 7 days, I felt unhappy. Item Response Theory (IRT): Category Response Curves very mildsevere Depressive Symptoms very mildsevere Depressive Symptoms Never Rarely Some times Often Always In the past 7 days, I felt I had no reason for living.


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