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Cell injury p.1 SYLLABUS: Robbins and Cotran, Pathologic Basis of Disease, Chapter: Cellular Responses to Stress and Toxic Insults: Adaptation, Injury,

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Presentation on theme: "Cell injury p.1 SYLLABUS: Robbins and Cotran, Pathologic Basis of Disease, Chapter: Cellular Responses to Stress and Toxic Insults: Adaptation, Injury,"— Presentation transcript:

1 Cell injury p.1 SYLLABUS: Robbins and Cotran, Pathologic Basis of Disease, Chapter: Cellular Responses to Stress and Toxic Insults: Adaptation, Injury, and Death excluding: hypertrophy hyperplasia metaplasia necrosis apoptosis cellular aging

2 15Lipofuscin storage in myocardial cells 7929/09Lipomatous (adipose) atrophy of the pancreas 17Liver steatosis 22Hyaline degeneration of the fibrous tissue 20 Calcification 3520/10Gout (gouty tophus) Cell injury p.1

3 - cardiomyocytes containing yellowish-brown intracytoplasmatic granules in a perinuclear location (candle flame shape) Lipofuscin storage in myocardial cells

4 (hematoxylin only)

5 Lipofuscin storage in myocardial cells

6 Lipomatous atrophy of the pancreas - replacement of the pancreatic acini by adipose tissue - large areas of total adipose atrophy isolating islands of Langerhans - dilated pancreatic ducts and periductal fibrosis

7 Lipomatous atrophy of the pancreas

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10 (paraffin block, H&E): -clear vacuolar spaces within hepatocytes (accumulated triglycerides were dissolved and removed from cells during the tissue processing) (frozen tissue sample, Sudan III): -vacuoles with orange-stained substance (fat) (.ppt demonstration only, no slides during the microscopy lab) Liver steatosis

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13 (paraffin block, H&E): -clear vacuolar spaces within hepatocytes (accumulated triglycerides were dissolved and removed from cells during the tissue processing) (frozen tissue sample, Sudan III): -vacuoles with orange-stained substance (fat) Liver steatosis

14 Liver steatosis (Sudan III)

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16 - thick, eosinophilic collagen fibers - few fibroblasts Hyaline degeneration of the fibrous tissue

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19 Calcification basophilic calcium deposits within the artery wall

20 Calcification

21 (empty areas within the calcium deposits are artifacts)

22 Gout (gouty tophus) - clusters of pale-staining monosodium urate crystals surrounded by macrophages, lymphocytes and large foreign body giant cells

23 Gout (gouty tophus)

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