Presentation on theme: "ART-IVF: the Long and Short of it Professor Ernest Hung Yu NG Department of Obstetrics & Gynaecology The University of Hong Kong."— Presentation transcript:
ART-IVF: the Long and Short of it Professor Ernest Hung Yu NG Department of Obstetrics & Gynaecology The University of Hong Kong
The Nobel Prize in Physiology or Medicine 2010 Robert G. Edwards for “Development of In Vitro Fertilization”
Louise Brown: First test-tube baby 9 October, 1978 12 July 2008
Key developments in assisted reproduction YearEventKey investigators 1880First attempts at IVF in mammalian eggsSchenk 1890First successful egg recovery from rabbitHeap 1893First successful embryo cultureOnanoff 1930First successful IVF in mammalian eggs resulting in a livebirthPincus 1952Time of ovulation established in human beings by laparoscopyRock 1971First human blastocyst seen in vitroSteptoe and Edwards 1972Mouse embryo successfully cryopreserved and thawed with survivalWilmut 1978Birth of Louise Brown, first human born after IVFSteptoe and Edwards 1983First pregnancy after replacement of cryopreserved embryoTrounson 1990Preimplanation genetic diagnosis first describedHandyside 1992Intracytoplasmic sperm injectionPalermo
Aims of ovarian reserve testing 1. To counsel patients about the likely ovarian response 2. To individualise stimulation regimes and FSH dose 3. NOT to advise against treatment in couples with “poor prognosis”
AFC and AMH in prediction of ovarian response and non-pregnancy l Poor ovarian response l Non-pregnancy (Broer et al, F&S 2008)
1,156 women in the first IVF cycle Cumulative live birth in the fresh plus all the frozen embryo transfers after the same stimulation cycle Both AMH and AFC were not significant predictors of cumulative live birth after adjusting for age and number of embryos available for transfer.