Presentation on theme: "Writing NIH Career Development (K) Awards"— Presentation transcript:
1Writing NIH Career Development (K) Awards OverviewBreaking Down the K AwardTask ListAdditional ResourcesArdis Hanson PhDCollege of Behavioral and Community Sciences 2013
2What is a K Award 3 – 5 years in length Career Development Awards (K awards) are one of the most successful NIH programs.Over the past 5 years, K award funding has steadily increased NIH-wide, and in 2011, overall K award success rates were 35% across all institutes.3 – 5 years in lengthProvide substantial salary support but limited research funding.Contains both a training plan and a research plan.Includes a team of mentors, co-mentors, advisors, etc.Goal: Transition to research “independence”.
3Mentored K awardsIntent is to help promising new investigators achieve research independence and compete successfully for R01 funding.The K award is the preparation for the R01 grant application you will submit at the end of the K award.If you already have substantial formal training in research, emphasize the importance of ‘hands-on’ research experience.Reviewers expect you to fully exploit the training resources available to you.
4Mentored K awards (continued) Craft a compelling argument why you need a K awardExplain exactly how additional training and mentored research experience will enable you to compete successfully for R01 funding.Be specific: give concrete examples of areas whereyou need additional training or experience in order to conduct the proposed research orareas where you are deficient that are directly related to your research career goals.
5Mentored K awards (continued) The career development training plan should be uniquely suited to you.Propose a mix of didactic training and “hands- on” research experience that make perfect sense for you (and only you) based on your previous training and research experience, and your short- and long-term career goalsIf you are considering degree-granting programs to acquire formal training in research, remember to customize the program whenever possible.
6Review CriteriaQuality of the candidate’s academic and clinical record.Potential to develop as an outstanding independent researcher.Likelihood that the career development plan will contribute substantially to the scientific development of the candidate.Appropriateness of the content and duration of the proposed didactic and research phases of the award.Consistency of the career development plan with the candidate’s career goals and prior research experience.
7Breaking Down the K Award The Candidate SectionStatements by Mentors, Co-Mentors, and CollaboratorsEnvironment and Institutional CommitmentResearch PlanHuman SubjectsBudgetsBiosketchAbstract & Project NarrativeCover Letter and Letters of Reference
84 Main Sections The Candidate (Sections 2 – 5) Statements by Mentors, Co-Mentors, and Collaborators (Section 7; limited to 6 pages)Description of Institutional Environment (Section 8; limited to 1 page)Institutional Commitment to Candidate’s Research Career Development (Section 9: limited to 1 page)Research Plan (Sections 10 and 11)
10The Candidate Section 2: Candidate’s background Section 3: Career goals and objectivesSection 4: Career development activities during award periodSection 5: Training in the responsible conduct of researchBe brief and conciseSections the Research Strategy (Section 11) combined cannot exceed 12 pages.
112. Candidate’s Background Suggested length: Less than 1 page.Use your NIH biosketch as a guide for the personal narrative of your professional career.Explain why you made key career choices, such as training opportunities or research projects).OK to use 1st person.Examples of the opportunities you’ve had to engage in research (basic or clinical) shows evidence of your long-standing commitment to research.Highlight early evidence of productivity (e.g., pursuing a specific question, analyzing data, presenting or publishing your results).Describe any formal research training (e.g., TICR, MPH).
12How to StartBegin this section with a summary statement regarding your long-term research career goals.Example: NEED GOOD EXAMPLE
13Section 3: Career Goals and Objectives Suggested length: paragraphsYour proposed research plan should include specific ‘challenges’ that requires additional training and/or experience for you to accomplish successfully.These challenges (deficits) in your training/experience then become the focus of your career development training plan.Example: NEED GOOD EXAMPLE
14Section 4: Career Development Activities During Award Period Suggested length: pages.List the specific training areas you will pursue to acquire the set of skills you need.Explain why additional training and mentored research experience in these areas are critical to accomplish your short-term and long-term career developmentDescribe in detail how you will gain this trainingspecific courses, individualized tutorials, or practical experience from conducting the researchExample: NEED GOOD EXAMPLE
15Section 5: Training in the Responsible Conduct of Research Format: To ensure general proficiency, I will take the following Courses [titles] designed to address the requirements of NIH for education of investigators about ethical issues in human subject research.Subject matter: I will have an understanding of the regulations that govern human subjects research, as well as training modules of the Health Insurance Portability and Accountability Act as it applies to research. In additional modules I will learn how to identify and resolve common ethical dilemmas that arise in clinical research, how research on human subjects is regulated by the federal government, and what constitutes research misconduct.Faculty participation:Duration of instruction:Frequency of instruction: I will receive my most intensive instruction in responsible conduct of research during the first two years of this proposal. However, I will continue to receive guidance from my mentors and scientific advisors throughout all five years of this proposal.
16Statements by Mentors, Co-Mentors, and Collaborators
17Assembling a TeamEstablish a relatively small (3-4) mentoring committee.Each member of your “team” must play a role in your training or research plan.Primary mentor should be a USF senior investigator with a track-record of NIH fundingCo-mentors should complement the primary mentor’s strengths and be located within the Tampa Bay area.If you need to add additional members, call them scientific or technical advisors/collaborators with a relatively narrow focal area and area of responsibility.
18Considerations This section is limited to 6 pages. Each member of your team must submit a signed letter.The primary mentor’s letter should be at least 2 pages.The rest of the team has only 4 pages.Make sure that the letters are consistent with the text in the grant applicationFrequency of meetingsEvaluation measures/benchmarksResources and tools
19Letters of Collaboration Should also address the candidate’sPotential for conducting original researchEvidence of originalityAdequacy of research backgroundQuality of research endeavors/publications to dateCommitment to researchNeed for further research experience and training
20Primary Mentor LetterAppropriateness of mentor’s research qualifications.Quality and extent of mentor’s role.Previous experience in fostering junior researchers.History of productivity and support.Adequacy of support for the research projectShould also re-frame any potential weaknesses in the application.Candidate productivity (few publications).Feasibility of conducting research plan with K award monies.Primary mentor’s limited mentoring experience.Limited resources of primary mentor.
21Letters of Collaboration Letters from co-mentors et al. can be much shorter.Include description of their role as co-mentor etc.Describe qualifications specific to the proposed research area.Include previous experience as a research supervisor and the nature and extent of supervision they will provide.Describe how they will evaluate your progress.Include specific benchmarks (e.g., manuscripts submitted).Include specific resources that will support you during your training and/or research with them.
23Description of Institutional Environment Evaluation criteriaAdequacy of research facilitiesAvailability of appropriate educational opportunities.Quality and relevance of the environment for scientific and professional development of the candidate.This section is limited to 1 page.
24Institutional Commitment Evaluation criteriaScientific development of the candidateCandidate will be “an integral part of its research program.”At least 75% of the candidate’s effort for proposed career development activities.These assurances are stated in a letter from your department chair or dean.This section is limited to 1 page.
25Letters of Recommendation 3 - 5 letters are required from any period in your career.Cannot be from your primary mentor or co-mentors.From senior investigators with history of NIH funding and training of junior investigators.Should address the candidate’s potential for a research career.Potential for conducting researchEvidence of originalityAdequacy of scientific backgroundQuality of research endeavors or publications to dateCommitment to researchNeed for further research experience and training
27The research plan isA training vehicle which should be well integrated with your career development training plan.A means to achieve independence (goal is an R01).Modest in scope, feasible, and appropriate.Think modular: secondary analyses of existing data, leverage ongoing studies, or conduct a small pilot study.Address a clearly defined problem where each specific aim contributes to addressing that problem.These applications are easier to write and easier to understandMinimize your vulnerability in reviewMaximize your ability to successfully conduct your proposed research.
28Evaluation CriteriaDoes your topic fit the mission of the NIH and match a funding priority of your NIH institute?Is your research grounded in cure, prevention, or intervention?What impact will your research have on public health?
29Effective Strategies Build a team Develop a good idea Seek opportunities for collaboration and identify collaborators to fill gaps in your expertise.Consider multidisciplinary approaches.Recruit senior colleagues who can provide advice and periodic peer-review of your grant applicationDevelop a good ideaConcentrate on ideas that impact practice and/or research.Conduct a thorough, and systematic, review of the existing literature.Pose interesting, important, and testable hypotheses.
30Effective Strategies (continued) Focus on grant writing fundamentalsAddress a clearly defined problem.Extend NIH knowledge by proposing interesting, important, and testable hypotheses that build on previous research.Propose a scope of work that is appropriate to the track record of the principal investigator.Don’t procrastinateGet started at least 4-6 months before the application is due.Arrange a dedicated time each week for grant-writing.Build in time for a good and thorough peer review before you submit.‘Good enough’ is not good enough.
31Specific Aims Length: 1 page Style: Non-technical. Write this section for the naïve reader. All study section members will all read it.This section must include everything that is important and exciting about your project.Keep it linear and upper level. Don’t get bogged down in details.This section, together with the Significance and Innovation subsections, are the most important parts of the application to receive an affirmative vote of the majority of reviewers.
32Specific Aims: Introductory Paragraphs Start with an sentence that captures the reader, immediately establishes the relevance of your proposal, and starts a compelling argument for funding.Describe the scope of the problem (e.g., number of people affected, morbidity/mortality, costs to society).Describe the gap in knowledge that your project will address (builds the project rationale)Reflect your “niche” area of research expertise.State your long-term goal: Relevance to public health and its part of a larger research plan (to get an R01).
33Specific Aims: Introductory Paragraphs (continued) State the objective of this applicationEach aim should consist of one concrete and concise sentence.Emphasize “product” over “process.”Keep the number of aims to a minimum (2-4).Aims should be able to “stand alone”; related but independent.Include rationales, when needed.Link this to your long-term goal (i.e., next logical step along a continuum of research).End with a rationale that tells reviewers why the expected outcomes from your study will clearly advance the field.
34Research Plan: Research Strategy SECTIONSSpecific AimsResearch StrategySignificanceInnovationApproach
35Definitions Length: 1 page, inclusive of both sub-sections Style: Non-technical.Justification for the need to research this area.Significance: The positive effect that successful completion of your research project is likely to have by solving an important, NIH-relevant problem.Innovation: A new and substantially different way of addressing an important, NIH-relevant problem, which enables departure from the status quo.
36SignificanceIncreases the level of detail that will extend and validate what was written in the Specific Aims section.Provide a critical analysis of the primary literature that describes the existence of a critical gap in knowledge.Use some of the material from the “Background” section to substantiate and validates this as an important problem.Explain why this problem must be resolved.Describe the contribution you expect to make. [EXAMPLE]Write a simple, direct statement why the expected contribution is important. [EXAMPLE]Describe the positive impact your contribution will have (e.g., new ways of conducting research, decreased mortality/morbidity, QoL or Tx outcomes, reduction in cost of medical care, etc.)
37InnovationEmphasis on a new and substantially different way of addressing a critical NIH-relevant problemProvide the context (with citations from the literature) so reviewers can understand how your project is innovative.Again, borrow from the Background section with discussion of previous approaches and why they were unsatisfactory. [EXAMPLE]“The proposed research is innovative because…..” states what objectively sets your project apart (approach or technology) compared to past investigators. [EXAMPLE]Describe the positive impact that will result from your innovative approach that ties it as a concrete benefit to the NIH mission. [EXAMPLE]
38ApproachDescribe the overall strategy, methodology, and analyses to be used to accomplish the specific aims of the project.Discuss potential problems, alternative approaches, and benchmarks for success anticipated to achieve the aims.If the project is in the early stages of development, describe strategy(ies) to establish feasibility and address management of any high-risk aspects of the proposed work.If this is a new application, include information on Preliminary Studies as part of this section.
41Human Subjects Research A part of the peer review process will include careful consideration of protections from research risks for study participants, as well as the appropriate inclusion of women, minorities, and children.[Example]The Study Section assesses the adequacy of the safeguards of the rights and welfare of research participants and the appropriate inclusion of women, minorities, and children.Evaluation of the inclusion plans arefactored into the overall score for scientific and technical merit.
43BudgetsMentored K awards provide salary support for the candidate $75,000/year) plus $25,000 to $50,000/year to cover the costs of the proposed training and research.Amount of salary support and funds for research/training differ by institute.A detailed, itemized budget is not required by NIH but it is required by USF.You are required to provide to NIH a detailed description and justification for specific items in the budget.[Example]
45BiosketchesThis section must include the biographical sketches of all Key Personnel and Other Significant Contributors.All biosketches must include a “Personal Statement”[EXAMPLE]The section on publications should be limited to 15 (include only the most relevant, recent, and important).For the candidate only, the section on Publications must be divided into the following categories:Original researchNon-experimental articles (e.g., literature reviews, book chapters)Books, pamphlets, etc.
47Facilities and Other Resources Describe the Facilities and Other Resources used to conduct the research.[EXAMPLE]Describe capacities, pertinent capabilities, relative proximity, and extent of availability to the project.
49Abstract & Project Narrative Limited to 30 lines of text (size 11 font, .5” margins).Describes both the career development plan and the research plan.[EXAMPLE]Project NarrativeOnly 2 or 3 sentences long.Explain the relevance of the proposed research to public health.Plain language, think naïve reader.
51Cover letterYou must include a cover letter with your K award application.It should request assignment to a specific institute.It must also list the names, department affiliation, and institution of 3-5 referees submitting letters of reference
52Letters of reference Critical importance Should address the candidate’s competence and potential to develop into an independent investigator.Must be submitted electronically by the referee through the eRA Commons.
54Task (To-do) ListDevelop a list of all components of your grant application package, including those required by the USF Office of Sponsored Research (OSR).[EXAMPLE]Indicate who is responsible for completing each component.Develop this list in collaboration with your RSA (research support analyst), who will help you compile the grant application for submission to the USF/OSR and NIH.
55Standard K Award Deadlines New applications: Feb. 12, June 12, and Oct. 12Resubmissions: March 12, July 12, November 12Standard AIDS/AIDS-related: May 7, Sept. 7, Jan. 7
57Career Development Award Resources NIH K Kiosk: This site provides a description of various Career Development Awards, along with eligibility considerations and funding policies.K Award Wizard: The K wizard uses a decision-tree format to help users determine which K award(s) is most appropriate.Applicants for K-series awards use the Application Guide SF424 (R&R): Adobe Forms Version B Series. Section 7 contains supplemental instructions for K applications.Chapter 12 NIH Grants Policy Statement (GPS) outlines K award policies (v. 10/1/2011).
58Background ReadingNIH Individual Mentored Career Development Awards Program (2011)Research Training in the Biomedical, Behavioral, and Clinical Research Sciences (2011)A Data-Based Assessment of Research-Doctorate Programs in the United States (2011)