Presentation on theme: "INHALABLE PARTICULATE MASS"— Presentation transcript:
1INHALABLE PARTICULATE MASS HISTORY, CURRENT TECHNOLOGY, AND DATA CONSIDERATIONSPresented by
2TOTAL DUST: HISTORY OF THE TERM Except in cases where diseases are caused by fine respirable dust, it has been common practice to sample so-called total dust.This is in general recognition that all inhaled particles could present either a specific or non-specific risk to health. (Mark and Vincent, 1986.)Total dust, however, was never defined by a specific size range and a 50% cut-point (D50) was never established for total dust samplers.
3THE FIRST DUST SAMPLERS: U.S.A. The initial work on dust sampling was done by the US Bureau of Mines.In the 1920’s, impingers were used to collect dust which was reported as TOTAL NUMBER OF PARTICLES i.e. millions of particles per cubic foot of air.Since impingers are cumbersome, health and safety professionals in the U.S. replaced them with 37-mm filter cassettes over time.(Harper, 1997)
4DUST SAMPLERS: GLOBALNot all countries have standardized on 37-mm filter cassettes for total dust sampling.Given the vague definition of total dust, a number of personal samplers with various performance characteristics have been used for sampling total dust around the world.
5TOTAL DUST SAMPLERS: UNITED KINGDOM Single Hole Lead Head for MDHS 6Seven Hole Head for MDHS 14SKCSKC
6SURPRISING STATISTICS: SAMPLER PERFORMANCE There is very limited data available on how well these samplers actually measure the true dust exposure.Studies show considerable differences in results from these various samplers when sampling the very same dust under the identical environmental conditions.≠≠
7SURPRISING STATISTICS: LIMITATIONS OF 37-MM CASSETTES 37-mm Filter Cassettes:Were never designed to represent a “physiologically relevant exposure” to the respiratory system.Aspiration efficiency is not very similar to the nose and mouth.Are not 100% efficient in collecting all sizes of dust particles.Have a upper size limit (approx. 30 um) where efficiency falls to zero.(T. Renee Anthony, AIHCE 2011)
8SURPRISING STATISTICS: ERRORS WITH 37-MM CASSETTES Sampling errors with 37-mm cassettes canbe evidenced from:Ambient wind velocity effectsOrientation effectsDust deposition on walls of cassette
9SO WHY DO WE USE THEM? In the U.S., we have been using 37-mm cassettes because:“Reductions in exposures as measured with these have been associated with reductions in health effects”.Cheap and EasyUsed by compliance officersHistory-Years of data on file
10SEARCHING FOR A BETTER WAY NEW CRITERIA FOR DUST SAMPLING Beginning in the1980’s, occupationalhygiene experts fromaround the worldbegan to investigate abetter way toevaluate particulates inthe workplace.First, was the need for standards (guidelines) that reflect closely the nature of human exposure.Secondly, was the need for samplers that collect the “physiologically relevant” size fraction of interest.
11WHY CHANGE?Measuring dust concentrations with the same efficiency as we inhale them makes better sense when evaluating the health-related dose.
12SEARCHING FOR A BETTER WAY NEW CRITERIA FOR STANDARDS Committees from ISO, CEN, and ACGIH have come to an agreement on new criteria.Many occupational hygiene bodies around the world have now adopted this criteria.Health-related sampling should be based on the following particle size-selective fractions:Inhalable, Thoracic, and Respirable.
13NEW CRITERIA: DESCRIPTIONS Inhalable-the fraction that enters the nose and/or mouthduring breathing (D50 of sampler= 100 um)Thoracic-the sub-fraction of inhalable that penetratesinto the respiratory tract below the larynx(D50 of sampler= 10 um)Respirable-the sub-fraction of inhalable that penetratesto the alveolar region of the lung. (D50 of sampler= 4 um)(AIHA Aerosol Committee Publication)
15ACGIH: ADOPTED NEW CRITERIA In 1993, revisions to the Appendix “Particle Size-Selective Sampling Criteria for Airborne Particulate Matter” were made by ACGIH.At this time, ACGIH adopted and defined inhalable, thoracic, and respirable particulate mass fractions.See page 78 of the 2014 TLV handbook.
16NIOSH: STATUS OF NEW CRITERIA NIOSH has NOT formally adopted the new criteria in total.Inhalable-NIOSH Method 5700 for formaldehyde on dust is the only method.Thoracic-NIOSH Method 5524 for metalworking fluids is the only method.Respirable-NIOSH Methods for respirable dust now specify a cyclone with a D50 of 4 um with several options listed. Ex. See Definition on upper left of NIOSH Method 0600.
17OSHA: STATUS OF NEW CRITERIA U.S. OSHA has not officially adopted the new criteria as it requires Congressional action like with PEL updates.OSHA Letter: SKC has a letter on file indicating that the IOM Sampler is “more efficient” in sampling small and large particles than 37-mm cassettes and can be used for compliance sampling of particulates not otherwise regulated.
18OSHA: STATUS OF NEW CRITERIA In the OSHA Notice of Proposed Rulemaking on Respirable Crystalline Silica, OSHA indicates that measurement should be determined by a sampling device designed to meet ISO 7708:1995 (page 538).This will harmonize OSHA’s practice with current aerosol science and most other agencies around the world including ACGIH and NIOSH.
19INHALABLE PARTICULATE MASS: DEFINED Those materials that are hazardous when deposited anywhere in the respiratory tractIncludes particulate matter that enter the head airways region including the nose and mouthAlso includes materials that can produce systemic toxicity from deposition anywhere in the respiratory system.
20INHALABILITY CRITERION: FURTHER COMMENTS The current criterion for inhalable dust is not perfect, but represents a best-guess based on decades of research.A known flaw: The current inhalability criterion underestimates human intake in calm air and low velocity environments.(Volckens, AIHCE 2011)
21DUST SAMPLERS TO MEET THE NEW CRITERIA After the creation of new criteria for standards researchers began to develop new samplers to meet the new criteria.These new sampling devices were designed to collect a biologically relevant fraction of dust found in the workplace.
22THE IDEAL INHALABLE SAMPLER An inhalable sampler is considered ideal “when a personal sampler mounted on the body gives the same measured dust concentration and aerodynamic size distribution as that inspired by its wearer, regardless of dust source location and wind conditions”. (Mark and Vincent, 1986)(Note: Inhalable dust was originally called inspirable dust.)Inhalable samplers have a D50 of 100 microns.
2337-MM FILTER CASSETTESDo not effectively sample the inhalable fraction.They significantly underestimate the concentration of larger dust particles fromum.Of particular concern are sample losses that occur from particles that adhere to the interior cassette walls.
24JOEH ARTICLE BY NIOSH NIOSH Researchers report: Dust deposits on the walls of filter cassettes were 19% of the total sample for lead and 25% of the total sample for copper.Filter cassettes should be rinsed AND WIPED prior to analysis.Results of wiped 37-mm filter cassettes are a closer match to results from inhalable samplers.(Ashley, Harper, Demange, 2007)
25INHALABLE SAMPLERS: DESIGNED FOR THE NEW CRITERIA The first personal sampler specifically designed for inhalable particulate mass was developed by Mark and Vincent in 1986 at the Institute of Occupational Medicine in Scotland.The sampler was named the IOM sampler and SKC Ltd. in the UK was the sole licensee and exclusive manufacturer of this sampler for more than 20 years.The patent has now expired, but SKC is still the only company that can call this device the IOM Sampler.So what are these so called “inhalable” samplers?
27USING THE IOM SAMPLER GRAVIMETRIC ANALYSIS Load a 25-mm filter into the cassette using forceps and wearing gloves.Equilibrate the filter/cassette assembly overnight under controlled humidity conditions then weigh them as a unit.Allow the assembly to stabilize a few minutes before taking a reading.Note: Do not desiccate the filter/cassette.
28USING THE IOM SAMPLER GRAVIMETRIC ANALYSIS Place the IOM cassette/filter assembly into the sampler body, screw on the cover cap, and connect to the pump.Calibrate the flowrate to 2 L/min using the IOM calibration adapter or by placing in a calibration jar.Following sample collection, weigh the cassette/filter assembly again.Referenced in HSE Method MDHS 14/3
29INHALABLE PLUS RESPIRABLE WITH GRAVIMETRIC ANALYSIS Aerosol physicists at the UK Health & Safety Laboratory have published on the use of polyurethane foam discs (SKC ) inserted into the front of the IOM cassette for size-selective sampling. (Kenny, Chung, et. al., 2001)The foam scrubs out large inhalable particles.Dust on Filter = Respirable fractionDust on Filter + Foam = Inhalable fraction
30USING THE IOM SAMPLER WITH OTHER TYPES OF ANALYSES The IOM Sampler is also available with a stainless steel cassette.(SKC A)This cassette is typically used for chemical (elemental) analysis where a solvent rinse is done inside the cassette.A stainless steel IOM body along with a stainless steel cassette is available for those using the sampler for bioaerosol sampling.(SKC A)This model allows for autoclaving.
31ADVANTAGES OF THE IOMDeveloped specifically to match the inhalable definition.Best fit with the inhalable curve under many circumstances.Internal wall deposits are included in the sample analysis.Can be combined with a foam insert to collect the respirable fraction simultaneously.
32DISADVANTAGES OF THE IOM Tends to oversample in low wind speed and when large particles are present.Large inlet allows sampling of large projectiles (Ex. Blasting operations)Higher limit of quantitation due to weighing of cassette.Designed as a personal sampler only; not for area sampling.(Volckens, AIHCE 2011)
33WEIGHING ACCURACY OF IOM SAMPLES RESPONSEThe type of plastic material was changed to address water adsorption.Do not desiccateEquilibrate under controlled humidity conditions.Consider stainless steel cassettes if necessary.CONCERNSMarch/April 1999 AIHA Journal article discussed problems of water absorption by plastic IOM cassette and resulting instability of the tare weight
34OTHER INHALABLE SAMPLERS: FROM SKC Button SamplerDeveloped by Univ of CincinnatiInlet has a stainless steel inlet screen with numerous, evenlyspaced holes.Screen keeps out large, non-inhalable projectilesfrom impacting or splashing onto the filter.SKC
35USING THE BUTTON SAMPLER SAMPLE LOGISTICS Unscrew the sampler inlet and remove the Teflon® O-ring.Place a 25-mm filter on the stainless steel support screen, replace the 0-ring and the sampler inlet.Calibrate the Button Sampler to a flowrate of4 L/min using the calibration adapter or by placing in a calibration jar.
36USING THE BUTTON SAMPLER SAMPLE LOGISTICS A filter pore size of 1.0 um or higher is recommended due to the backpressure limitations of most personal samplers.After sampling, remove the filter for analysis.Use a conductive plastic filter transport case (SKC ) or Filter-Keeper (SKC ) for shipment to the lab.
37ADVANTAGES OF BUTTON SAMPLER Good precision and fit with the inhalable curveInlet screen keeps out large particlesLow sensitivity to wind velocity and directionUniform collection on the filterFlow rate of 4 L/min for personalsampling increases sensitivityCan be used for personal or area sampling
38DISADVANTAGES OF BUTTON SAMPLER Inlet holes can become clogged (i.e. flour dust)Liquid aerosols not collected as efficiently as solid aerosolsDust deposited on sampler walls and O-ring are not included in sample analysis.
39OTHER INHALABLE SAMPLERS: FROM SKC IN UK 7-HOLE SAMPLING HEADTraditional European method using a 25-mm filter and cassette with an end cap with 7 equispaced inlet holes with flows of 2.0 L/min.Listed in HSE MDHS Method 14, but not widely studied.7-HOLE (DEAD) HEAD ??
40INHALABLE SAMPLERS: FROM OTHER SUPPLIERS Conical InhalableSampler (CIS)Also known as the GSPSampler. This Germansampler aspiratesparticles through theinlet at 3.5 L/min onto a37-mm filter. Limitedcommercial availability.CIS SAMPLER
41INHALABLE SAMPLERS: FROM OTHER SUPPLIERS CIP-10A French sampler with2 key components:1. Impactor/foampre-separator to retainlarge particles2. A rotating cup with aPUF ring that collects thesample for gravimetricanalysisCIP-10 SAMPLER
42INHALABLE SAMPLING OF BERYLLIUM: REUSE ISSUES SKC consulted withNIOSH for advice ondecontamination andreuse of inhalablesamplers usedto sample beryllium.NIOSH does not clean/reuse these cassettes due to safety and cross-contamination concerns with Be.They recommend using 37-mm cassettes and wiping the walls to account for wall losses. The results will be comparable to those using inhalable samplers.
45DATA CONSIDERATIONS 2014 INHALABLE TLVs® GlyoxalHexahydrophthalic anhydrideIodine and IodidesIsobutyl nitriteMagnesium oxideMalathionMaleic anhydrideManganeseMethomylMethyl demetonMethyl parathionMevinphosMineral oil, excluding metal working fluidsMolybdenum (Metal and insoluble cpds.)Monochloroacetic acidMonocrotophosNaledNatural rubber latex as total proteinsNickel, Elemental, Soluble and Insoluble Cpds.Nickel Subsulfide5-Nitro-o-toluidine
46DATA CONSIDERATIONS 2014 INHALABLE TLVs® p,p-Oxybis(benzenesulfonyl hydrazide)ParathionParticulates Not Otherwise Specified (now a guideline; not a TLV)PentachlorophenolPeracetic Acid (PAA)Phoratem- and o-PhthalodinitrilePiperazine and saltsRonnelSilicon carbide, nonfibrousSulfotepp (TEDP)SulprofosSynthetic Vitreous Fibers (Continuous filament)TemephosTerbufos1,1,2,2-Tetrabromomethane
482014 INTENDED CHANGES TO TLVs® ISSUED AS INHALABLE Calcium SilicateEthylene GlycolLithium hydrideSimazine2,4- or 2,6- Toluene diisocyanateTrimetacresyl phosphateTriorthocresyl phosphateTriparacresyl phosphateFor TLVs with IFV notation(Inhalable fraction andvapor)May require 2 separate samples due to flowrate issues for each contaminant phase.Chemically coated filters provide a solution for TDI.
49DATA CONSIDERATIONS TOTAL VS INHALABLE KEY REFERENCESJournal article-Werner, et al. (1996) Investigation into the impact of introducing workplace aerosol standards based on the inhalable fraction. Analyst 121:AIHCE 2011 Session-T. Renee Anthony. How to Relate Total and Inhalable Dust Exposures. From the session entitled Inhalable Particles: The State of the Science on a Big Particle Problem. (An electronic copy of this is available upon request.)
50DATA CONVERSION?? TOTAL VS INHALABLE Inhalable particulate mass is typically greater than total particulate mass.How much greater will depend upon the SIZE of the particles.With larger particles, inhalable particulate mass will be much greater than total particulate mass.With smaller particles, inhalable and total particulate mass will be comparable.
51DATA CONVERSION?? TOTAL VS INHALABLE Type of particulate Ratio of Results IOM/37-mm cassetteDust from powder handling, grinding 2.5Mist from paint spray or oil mist 2.0Hot Processes such as foundries 1.5Fumes from Welding*Werner, et al. (1996)
52DATA CONVERSION?? TOTAL VS INHALABLE Dr. Anthony’s AIHCE 2011 session makes the point that it is really not enough to use a simple conversion factor as given on the previous slide.Ratio of results can also vary with particle size distribution.“Using a standard correction factor without knowing your aerosol distribution may under- or over-estimate inhalable-converted exposure levels.”
53DATA CONVERSION?? TOTAL VS INHALABLE So what do you do?Collect both 37-mm cassette and inhalable samples and determine process-specific ratios for YOUR unique operation.
54SIDE-BY-SIDE SAMPLING: 37-MM VS INHALABLE SAMPLERS Will bridge your past data using total dust filter cassettes to that using inhalable samplers.Will provide backup data for any compliance related issues.
55THANKS FOR YOUR ATTENTION. PLEASE SKC WITH ANY QUESTIONS ON SAMPLING.