Presentation on theme: "Non-Invasive Glucose Measurement"— Presentation transcript:
1 Non-Invasive Glucose Measurement Barbara DeschampTimothy FicarraEric Murray
2 Overview Eric Barbara Tim VeraLight Scout DS LighTouch Glucose Monitor OrSense NBM-200GBarbaraGlucoScopeGlucoViewTimGlucoWatchEZ ScanSymphony tCGM
3 Spectroscopy Study of the interaction of matter and light 3SpectroscopyStudy of the interaction of matter and lightLight is focused on some area of the bodyLight is absorbed and reflected in different waysSubcategories include near-infrared, mid- infrared, and photoacoustic spectroscopy.Detect the presence of glucose by observing the reflectance of light against a sample.
4 4VeraLight, Inc.Scout DSConsists of a light source, an optical detector, and spectrometer, all located on an arm-rest.
5 5VeraLight, Inc.Uses spectroscopy to measure advanced glycation end products (AGE)Glycation occurs when a protein or lipid is bonded with glucose.Hyperglycemia from diabetes results in higher cellular glucose levels.This leads to increased glycation, and increased levels of AGE formation.Product is only useful for predicting the development of Type 2 diabetes.May eventually replace the current invasive diabetes screening methods.
6 LighTouch Medical, Inc. LighTouch Glucose Monitor 6LighTouch Medical, Inc.LighTouch Glucose Monitor12 issued patents, more pending.Projects a specific wavelength of light onto fingertip and detects the wavelength of reflected light.Designed for daily testing and accuracy equal to finger-stick method.Clinical trials began in 1999 with Joslin Diabetes Center, Syracuse, New York.Monitor has been continually redesigned since.
7 7LighTouch Medical, Inc.Improvements have been made in speed, accuracy, cost, and form-factor.Currently in the process of getting FTA approval.Plans on releasing home version six to nine months after approval.Potential to replace traditional method.Plans to use their technology for other blood analyte measurement devices.
8 OrSense Ltd. NBM-200G Glucose Monitor 8OrSense Ltd.NBM-200G Glucose MonitorSpecific version of their NBM-200MP which measures hemoglobin, oximetry, and pulse rate.Based on proprietary Occlusion spectroscopy technology.Sensor wraps around finger, applying pressure.The change in blood dynamics is used in allowing a strong optical response.51 patents worldwide, more than 20 pending.Developed the concept of measuring analytes through occlusion of blood flow, a unique finger sensor, and algorithms to facilitate the measurement.
10 OrSense Ltd. NBM-200G currently undergoing clinical trials. 1010OrSense Ltd.NBM-200G currently undergoing clinical trials.Tested on over 450 subjects over a 24-hour period“At this stage the NBM- 200G glucose monitor is utilized for investigation and market awareness purpose only”Image Source:
11 Overview Eric Barbara Tim VeraLight Scout DS LighTouch Glucose Monitor OrSense NBM-200GBarbaraGlucoScopeGlucoViewTimGlucoWatchEZ ScanSymphony tCGM
12 Glucoscope Monitor Produced by Visual Pathways Inc Received federal grant in 2003 under the U.S Department of the Army Medical Research Acquistion ActivityReceived a patent December 2004Measures the glucose levels in the fluid of the anterior chamber of the eye
13 Visual Pathways Inc A vision care diagnostic company Headquarters in Prescott, ArizonaDeveloped a prototype in 2003GlucoScope Monitor uses infrared light to rapidly measure glucose levels in the eyeThe handheld device looks like a small pair of binoculars
15 The Human Eye The cornea and a lens form the anterior chamber The anterior is also comprised of the iris and the aqueous humor
16 GlucoScopeGlucose concentration in the bloodstream is directly correlated to the concentration in the aqueous humorVariation in the glucose concentration will cause variations in its index of refractionThe refractive index can be measured by interferometry
17 InterferometryTwo beams are directed into the eye and caused to interfereThe interference produces a fringe pattern (bright and dark lines)The pattern is analyzed and the index of refraction of the eye is determinedThe glucose concentrations is then determinedThe glucose level in the blood can be determined from this information
18 Benefits of GlucoScope HandheldPortableDigital readout
19 Drawbacks Still in the research and development phase Not commercially available
20 Glucoview Produced by Sentek Group Inc Licensed from the University of PittsburgDisposable contact lens which changes color according to glucose levels in tearsUses a Crystalline Colloidal Array TechnologyA red shift indicates hyperglycemiaA purple shift indicates hypoglycemia
21 Crystalline Colloidal Array (CCA)Technology When the CCA is polymerized within a hydrogel PCCA , the PCCA optically reports volume changes experienced by the hydrogelThis is because the observed diffraction wavelength is directly related to the spacing between lattice planes
22 Crystalline Colloidal Array The CCAs are brightly colored because they diffract visible light due to Bragg’s diffractionnλ = 2dsinθwhere,n is an integerλ = wavelength of the incident waved is the spacingBragg diffraction depends on the refractive index of the system and the spacing between the diffracting planes
23 Benefits of Glucoview It is non-invasive (no finger pricks) It requires no instrumentation( to collect fluids or to analyze results)Provides easily measurable, quantitative resultsIt is low-costContinuous monitoringHelpful for caretakers of children and elderly
24 DrawbacksNecessary to wear contact lenses (most diabetics have vision problems)Does not collect data for future analysis
25 Overview Eric Barbara Tim VeraLight Scout DS LighTouch Glucose Monitor OrSense NBM-200GBarbaraGlucoScopeGlucoViewTimGlucoWatchEZ ScanSymphony tCGM
26 Reverse Iontophoresis Technique for extracting subdermal moleculesApply DC current to the skinCurrent attracts charged moleculesForce of the flow also draws neutral moleculesGlucose and lactate are among the molecules which can be extracted
27 GlucoWatchFirst commercially available non-invasive glucose measurement techniqueContinuous monitoringRequires blood test for calibrationSuffers inaccuracy in detecting hypoglycemiaDiscontinued by Animas Corporation in 2007
28 EZ Scan Tool for blood sugar testing Requires no calibration Two minute testUtilizes five sensorsIn regions rich with sweat glands2 hands, 2 feet, 1 foreheadRequires no calibrationStill in developmental stages
29 Image source: www.echotx.com Symphony tCGM SystemTransdermal Continuous glucose monitoringReal timeBiosensor broadcasts wirelessly to a monitoring toolNo calibrationUses a proprietary skin permeation device - PreludeImproves effectiveness of reverse iontophoresisImage source:
30 Prelude SkinPrep System Improves permeability of skin for reverse iontophoresisTool removes the outmost layer of epidermis (stratum corneum)Uses feedback control algorithm to prevent damage.01mm in thickness comprised of dead skinImage source:
31 Summary Spectroscopy and Reverse Iontophoresis Viable solutions for Non-Invasive Glucose MeasurementSymphony tCGM is one of the most viable candidatesBarbara maintains that the GlucoView will ultimately win
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