Presentation on theme: "Introduction to Infectious Disease Epidemiology - STDs -"— Presentation transcript:
1Introduction to Infectious Disease Epidemiology - STDs - Hsci 436 – Health Concerns of the AdolescentDr. E. Frank Spinello
2Pathogens Bacterial Viral Chemical toxins Parasitic (multi-cell) About 1 million on the head of a pinSalmonella, botulism, anthraxViralAbout 230 million HIV on the head of a pin.Not affected by antibioticsChemical toxinsOrganic and inorganicAllergens, carcinegens, neurotoxins, teratogensParasitic (multi-cell)tapeworms, trichinosis, schistosomesFungalyeast infections, CandidaProtozoaSingle cell organismsPrionsRelatively new discoveryInfectious agent with protein-like qualitiesThought to be responsible for BSE (mad cow disease) and vCJDDifficult to disinfectFungal Pathogens:Histoplasma -> Histoplasmosis, Coccidioidomycosis, and BlastomycosisToxins:
3Historical OverviewTraditionally, infectious disease was the biggest health threat to human civilization.As medical technology and public health reduced the threat of infectious diseases, lifespans increased to the point of making chronic diseases more prevalent.
4Infectious Diseases in History In the mid-1300’s about 23 million people in Europe died from plague.Plague-related deaths represented 10-15% of each new generation for a period of about 100 years.The population shifts changed the cultural and political makeup of Europe
5InfluenzaBy many estimates, major flu outbreaks occur about every 11 years.The 1918 flu pandemic killed million people within about 18 months.More people died worldwide than in all of the wars of the 20th century, combined.The 1976 swine flu scare resulted in a national immunization program.The fear was that the swine flu was a close variant of the 1918 virus and would trigger another pandemic.
6SyphilisIs thought to have been brought back by Columbus’ crew from the New World to Europe.Often treated with mercury, which resulted in many individuals with mercury poisoning.
7HIV/AIDS Human Immunodeficiency Virus was first detected in 1980. Confirmed index patient was a Canadian flight steward.The earliest known case may date back to 1958.
8New ConcernsIncreased frequency of travel combined with short travel times mean that pathogens are no longer geographically isolatedOne reason that Ebola has never spread has been the remote areas in which it is found.MDRs – Multiple drug resistant bacterial strains.A variety of bacteria no longer respond to traditional antibiotics as they have begun to mutate and adapt.Partially due to inappropriate antibiotic use.
9Sexually Transmitted Diseases Most common include:ChlamydiaSyphilisGonorrheaGenital herpesGenital warts (caused by the human papillomavirus)Hepatitis B
10PID ComplicationsPelvic Inflammatory Disease (PID) is a common complication of many STD’s in women:May be asymptomaticWhen symptoms are present, they can be very severe and can include abdominal pain and feverabscesses (pus-filled “pockets” that are hard to cure) and long-lasting, chronic pelvic paincan damage the fallopian tubes enough to cause infertility or increase the risk of ectopic pregnancy
11Chlamydia Caused by the bacterium, Chlamydia trachomatis The most frequently reported bacterial sexually transmitted disease in the United StatesOften undiagnosed due to lack of initial symptomsabout three quarters of infected women and about half of infected men have no symptoms. If symptoms do occur, they usually appear within 1 to 3 weeks after exposure.Symptoms include pain, discharge, bleeding.
12Chlamydia Untreated women Untreated men About 40% of women develop PID Can cause permanent damage to fallopian tubes, uterus, and surrounding tissue5 times more likely to become HIV infected if exposed.Chlamydia is a leading cause of early infant pneumonia and conjunctivitis (pink eye) in newborns.Untreated menComplications are rareSterility, eye infections, arthritis, skin lesions
13Chlamydia Diagnosis Treatment Prevention Urine or discharge specimen A single dose of azithromycin or a week of doxycycline (twice daily) are the most commonly used treatments.PreventionRetesting should be considered for women, especially adolescents, three to four months after treatment. This is especially true if a woman does not know if her sex partner received treatment.Condoms can reduce infection riskUpon diagnosis, all sex partners must be notified
14SyphilisCaused by the bacterium Treponema pallidum. It has often been called “the great imitator” because so many of the signs and symptoms are indistinguishable from those of other diseases.Most cases occur in people age 20 to 39About 3.5x more men than womenRates are decreasing in women but increasing about 12.5% in men due to MSM
15Syphilis Transmission Symptoms Direct contact with syphilis sore Genitals, lips, and mouthSymptomsES may not present symptoms for yearsPrimary stageInitial sore at point of contact w/in 90 days, heals w/o treatmentSecondary StageNon-itchy rash (appearing as red blotches or spots) on genitals, hands and feetSwollen glands, hair loss, headaches, weight loss, muscle aches, fatigueLatent syphilisInitial symptoms disappearUp to years later -- damage to internal organs and brain, nerves, eyes, heart, blood vessels, liver, bones, and jointsSymptoms include: difficulty coordinating muscle movements, paralysis, numbness, gradual blindness, and dementia, and death
16Syphilis Diagnosis Implications Requires smear from cancre sore. Dark field microscopy is usedBlood test to detect antibodiesImplicationsGenital sores (chancres) caused by syphilis make it easier to transmit and acquire HIV infection sexually. There is an estimated 2- to 5-fold increased risk of acquiring HIV infection when syphilis is present.
17Syphilis Treatment Prevention Syphilis is easy to cure in its early stages. A single intramuscular injection of penicillin, an antibiotic, will cure a person who has had syphilis for less than a year.PreventionAbstinenceAvoid risky behaviorCondom use, although N9 spermicide may cause lesions and increase risk.
18Gonorrheacaused by Neisseria gonorrhoeae, a bacterium that can grow and multiply easily in the warm, moist areas of the reproductive tract, including the cervix (opening to the womb), uterus (womb), and fallopian tubes (egg canals) in women, and in the urethra (urine canal) in women and men. The bacterium can also grow in the mouth, throat, eyes, and anus.
19Gonorrhea: OverviewCDC estimates that more than 700,000 persons in the U.S. get new gonorrheal infections each year.About ½ are reported to CDCTransmissionSexual contactHighest reported rates of infection are among sexually active teenagers, young adults, and African Americans.
20Gonorrhea: Signs and Symptoms MalesMay have no symptoms at all5 to 30 days after infection:Burning sensation during urinationWhite, yellow, or green dischargeSwollen/painful testicals (not all)FemalesMost have no symptomsOften non-specific and mistaken for bladder or yeast infectionInitial symptoms and signs in women include a painful or burning sensation when urinating, increased vaginal discharge, or vaginal bleeding between periodsSore throat
21Gonorrhea: Complications Malesgonorrhea can cause epididymitis, a painful condition of the testicles that can lead to infertility if left untreatedcan spread to the blood or jointsIncreases risk of HIV infectionFemalesPID - abdominal pain and fever
22Gonorrhea: Treatment and Prevention DiagnosisDoctors office can perform a Gram stain of a sample from a urethra or a cervix allows the doctor to see the gonorrhea bacterium under a microscopeTreatmentMultiple antibiotics are generally used due to co-morbidity with chlamydiaResistant strains are now being increasingly encountered
23Hepatitis BViral infection passed through bodily fluids from one person to another.High Risk Groups:Persons with multiple sex partners or diagnosis of a sexually transmitted diseaseMSMSex contacts of infected personsInjection drug usersHousehold contacts of chronically infected personsInfants born to infected mothersInfants/children of immigrants from areas with high rates of HBV infection (view map)Health care and public safety workers Hemodialysis patients
25Hepatitis B - Prevalence Number of new infections per year has declined from an average of 260,000 in the 1980s to about 78,000 in 2001.Highest rate of disease occurs in year-olds.Greatest decline has happened among children and adolescents due to routine hepatitis B vaccination. Estimated 1.25 million chronically infected Americans, of whom 20-30% acquired their infection in childhood.
26Hepatitis B – Signs and Symptoms About 30% have no symptomsSymptoms include:jaundicefatigueabdominal painloss of appetitenausea, vomiting joint painDeath from chronic liver disease occurs in 15-25% of chronically infected persons
27Hepatitis B - Treatment Adefovir dipivoxil, alpha interferon, and lamivudine are three drugs licensed for the treatment of persons with chronic hepatitis B.These drugs should not be used by pregnant women.Drinking alcohol can make your liver disease worse.
28Hepatitis B – Prevention Vaccination is best defense for high-risk individuals. Recommended for public health and public safety workers.Effectiveness of condom use is unknown but they are likely to help protect against it.Reduce IV drug use / syringe sharingDiscourage sharing of personal items (razors, etc.)Consider risks of tattoos and body piercing
29Genital Herpes - Overview Genital herpes is a sexually transmitted disease (STD) caused by the herpes simplex viruses type 1 (HSV-1) and type 2 (HSV-2).Most genital herpes is caused by HSV-2. Most individuals have no or only minimal signs or symptoms from HSV-1 or HSV-2 infection. When signs do occur, they typically appear as one or more blisters on or around the genitals or rectum. The blisters break, leaving tender ulcers (sores) that may take two to four weeks to heal the first time they occur. Typically, another outbreak can appear weeks or months after the first, but it almost always is less severe and shorter than the first outbreak. Although the infection can stay in the body indefinitely, the number of outbreaks tends to decrease over a period of years.
30Genital Herpes Prevalence 45 million people ages 12 and older, one out of five adolescents and adults, have had genital HSV infection.Between the late 1970s and the early 1990s, the number of Americans with genital herpes infection increased 30 percent.Genital HSV-2 infection is more common in womenapproximately one out of four womenalmost one out of five menThis may be due to male-to-female transmissions being more likely than female-to-male transmission.HSV-1 can cause genital herpes, but it more commonly causes infections of the mouth and lips, so-called “fever blisters.” HSV-1 infection of the genitals can be caused by oral-genital or genital-genital contact with a person who has HSV-1 infection. Genital HSV-1 outbreaks recur less regularly than genital HSV-2 outbreaks.
31Genital Herpes – Signs and Symptoms Most HSV-2 people are not aware of first infection.First outbreak is generally 1-2 weeks after infection and may last 3-4 weeks.First outbreak is generally accompied with swollen glands, fever, flu-like symptoms.4 to 5 five outbreaks in the first year, with decreasing frequency thereafter.Often mistaken for insect bitesComplicationsRecurrent painful outbreaksInfections in babies can be fatalIncreases HIV susceptibilityDiagnosisVisual inspectionBlood test to detect antibodiesLab test of sore samplesTreatmentNo cure but antiviral drugs can shorten and prevent outbreaksPreventionControl outbreaks to reduce risk of transmissionAbstinence during outbreaksCondoms may help reduce transmission risk but may not entirely cover infected areas
32Genital Warts Overview Prevalence Caused by Human Papillomavirus (HPV) About 100 strains, of which 30 are sexually transmittedHigh risk strains (about 10 of 30) can lead to abnormal pap smears and cause cancer of the cervix, vulva, vagina, anus, or penisLow risk types may cause mild Pap test abnormalities or genital warts. Genital warts are single or multiple growths or bumps that appear in the genital area, and sometimes are cauliflower shaped.PrevalenceAt least 50 percent of sexually active men and women acquire genital HPV infection at some point in their livesBy age 50, at least 80 percent of women will have acquired genital HPV infectionMost people will be asymptomatic and fight off infection on their own
33Genital Warts Diagnosis Treatment Complications Prevention Visual inspectionOften appear within weeks or months of contact, or not at allUsually appear as soft, moist, pink, or flesh-colored swellings, usually in the genital area. They can be raised or flat, single or multiple, small or large, and sometimes cauliflower shaped.TreatmentNo cure, but they will often go away on their ownRegular pap smears can help detect pre-cancerous conditions for early treatmentComplicationsCan cause cervical cancerPreventionAbstinence, particularly during outbreaksEffectiveness of condoms against HPV is unknown but condom use has been associated with a somewhat lower incidence of cervical cancer
34Current Research and STD Prevention Programs Debate between safer sex an abstinence programs.Research has tended to focus on one-time abstinence programs with no follow-up.Both approaches appear to work in the short term but SS programs tend to have longer term effects among sexually active teensAbstinence and safer sex among adolescents. Author: Masdeu JC Source: JAMA (JAMA : the journal of the American Medical Association.) 1999 Apr 28; 281(16): Libraries Worldwide: 3891Abstinence and safer sex HIV risk-reduction interventions for African American adolescents: a randomized controlled trial. Author: Jemmott JB 3rd; Jemmott LS; Fong GT Source: JAMA (JAMA : the journal of the American Medical Association.) 1998 May 20; 279(19):Haglund K found that African American’s description of abstinence only tended to include intercourseStill at risk for STDsSexually abstinent African American adolescent females' descriptions of abstinence. Author: Haglund K Source: J Nurs Scholarsh (Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing / Sigma Theta Tau.) 2003; 35(3): 231-6