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PATHOPHYSIOLOGY OF INFLUENZA. Pathophysiology Binding and destruction of epithelial cells from nasopharynx to alveoli SYSTEMIC BODY REACTION Fever, muscle.

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Presentation on theme: "PATHOPHYSIOLOGY OF INFLUENZA. Pathophysiology Binding and destruction of epithelial cells from nasopharynx to alveoli SYSTEMIC BODY REACTION Fever, muscle."— Presentation transcript:

1 PATHOPHYSIOLOGY OF INFLUENZA

2 Pathophysiology Binding and destruction of epithelial cells from nasopharynx to alveoli SYSTEMIC BODY REACTION Fever, muscle pain, etc. LOCAL INFLAMMATORY REACTION Upper respiratory infection Body response Droplets Aymard M. Vaccine 1995: 47–70.

3 Uncomplicated influenza Complications Sore throat, myalgia Headache Cough Malaise, prostration Coryza Onset of illness Kilbourne ED. Influenza. New York: Plenum Medical Book Company; 1987: 156– Oral temperature (°C) Time in days (RMKTCID 50/ml) LOG 10 nasopharyngeal virus titer Incubation period Virus isolation Fever curve

4 Overview – clinical symptoms Abrupt onset of symptoms Abrupt onset of fever, drop in temperature after 2 days, increase again Severe myalgia Sore throat Dry cough Retrosternal pain Severe malaise lasting several days

5 Symptoms of influenza Cough Malaise Feverishness Sudden onset Chills Headache Anorexia Coryza Myalgia Sore throat Sputum Dizziness Hoarseness Chest pain Vomiting Diarrhoea Abdominal pain Fever > 37.8°C Percentage of cases Nicholson KG et al., eds. Textbook of Influenza. Malden, Massachusetts: Blackwell Science; 1998.

6 Fulminant influenza Reported during pandemics The fulminant form can affect everyone Pulmonary manifestation Antibiotics are ineffective Influenza viral pneumonia DEATH Fever Cough Dyspnoea Cyanosis Aymard M. Vaccine 1995: 47–70.

7 By courtesy of APACI Asia-Pacific Advisory Committee on influenza


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