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Pathology Practical: Female Genital Tract.

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Presentation on theme: "Pathology Practical: Female Genital Tract."— Presentation transcript:

1 Pathology Practical: Female Genital Tract

2 The Slides  Slide 1: Intraductal Carcinoma of the Breast
Slide 2: Invasive Duct Carcinoma of the Breast Slide 3: Paget’s Disease of the Breast Slide 4: Dermoid Cyst of the Ovary

3 Intraductal Carcinoma of the Breast Slide shows the following:
Large ducts are distended by neoplastic epithelial cells which are pleomorphic with hyperchromatic nuclei; some exhibiting Mitoses Cells form imperfect acini and show Cribriform pattern Small groups of necrotic cells in the center of many ducts No invasion of Basement Membrane of the ducts

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5 Retracted Nipple surrounded by Thickened Areola
Brest Tissue replaced by grayish-pink fleshy tumor Orange Peel (Peau de Orange) appearance of skin

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7 Large distended ducts with necrotic cells in center

8 Cribriform pattern & Imperfect Acini

9 Invasive Duct Carcinoma of the Breast Slide shows the following:
Cords, Sheets & nests of tumor cells surrounded by dense fibrous tissue, stroma containing scattered lymphocytes Tumor cells are Round or Polygonal with deeply stained nuclei & occasional mitoses Focal tumor cells necrosis Invasion of Breast Adipose tissue by Tumor cells Few tumor cells form Duct-Like structures

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12 Tumor cell nest Dense Fibrous tissue Stroma

13 Invasion of Breast Adipose Tissue

14 Deeply Stained Round or Polygonal cells

15 Tumor cells forming DUCT-LIKE structures

16 Paget’s Disease of the Breast Slide shows the following:
Ulceration and invasion of epidermis by ductal carcinoma cells (Paget cells), present between basal cells in elongated rete pegs Paget cells are Large, anaplastic cells having pale cytoplasm, hyperchromatic nuclei with occasional mitosis Paget cells are present in either singly or in small groups of 2 or 3 surrounded by a clear zone “Halo” Deeper tissue shows Intraductal proliferation of neoplastic epithelial cells

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19 Ulceration & Invasion of epidermis by Paget Cells
Rete Pegs Paget Cells

20 Paget Cells Showing all previously mentioned Features:
-Large, anaplastic, pale cytoplasm, hyper chromatic Nuclei, clear Halo zone

21 Dermoid Cyst of Ovary Slide shows the following:
Stratified squamous epithelium with underlying appendages (sweat glands, sebaceous glands, hair follicles), columnar ciliated epithelium, mucous & serous glands and structures from other germ layers such as Bone, Cartilage, Lymphoid tissue, Smooth muscle and large area of Brain Tissue containing Neurons and Glial cells.

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24 Dermoid Cyst of the Ovary Containing Brain Tissue

25 Growth of Hair Follicles in Ovary


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