Presentation on theme: "Acute Renal Failure/Acute Kidney Injury"— Presentation transcript:
1Acute Renal Failure/Acute Kidney Injury Dr. Sudarshan Singh
2IntroductionAcute renal failure (ARF), or acute kidney injury (AKI), [as it is now referred to in the literature], is defined asAn abrupt or rapid decline in renal filtration functionCondition is usually marked by a rise in serum creatinine concentration or by azotemia (a rise in blood urea nitrogen [BUN] concentration)
3CausesAcute kidney failure appears most frequently as a complication of serious illness, likeHeart and/or liver failure, serious infection, dehydration, severe burns, and excessive bleeding (hemorrhage)May also be caused by an obstruction to the urinary tract or as a direct result of kidney disease, injury, or an adverse reaction to medicineThese conditions divide AKF into 3 main categories:PrerenalPostrenal, andIntrinsic (inside) conditions
4Causes Prerenal AKF Dehydration Does not damage the kidney, but can cause diminished kidney function and significantly decreased renal (kidney) blood flowMost common type of acute renal failure, and is often the result of:DehydrationExtracellular fluid (ECF) volume depletion (or other acute fluid loss from the gastrointestinal tract, kidneys, or skin)Drugs (NSAIDS, cyclosporine, radiopaque contrast materials, or any substance toxic to the kidneys)HemorrhageSepticemia, or sepsisCongestive heart failure (CHF)Liver failureBurnsDecreased intravascular volume (referred to as third spacing, also found in the presence of pancreatitis, post surgical patients, and patients with a nephrotic syndrome)
5CausesPostrenal AKFResult of an obstruction of some kind somewhere in the urinary tract, often in the bladder or ureters (the tubes leading from the kidney to the bladder)The kidneys compensate to such a degree that one kidney can be completely obstructed and the other will maintain nearly normal kidney function for the bodyThe conditions that often cause postrenal AKF are:Inflammation of the prostate gland in men (prostatitis)Enlargement of the prostate gland (benign prostatic hyperplasia - BPH)Bladder or pelvic tumorsKidney stones (calculi)
6CausesIntrinsic AKFInvolves a type of kidney disease or direct injury to the kidneys.Accounts for 20-30% of AKF reported among hospitalized patientsIntrinsic AKF can result from:Lack of blood supply to the kidneys (ischemia)Use of radiocontrast agents in patients with kidney problemsDrug abuse or overdoseLong-term use of nephrotoxic medications, like certain pain medicinesAcute inflammation of the glomeruli, or filters, of the kidney (glomerulonephritis)Kidney infections (pyelitis or pyelonephritis)Infiltration by lymphoma, leukemia, or sarcoid carcinomas
7The Four Phases of Acute Renal Failure Onset Phase – this period represents the time from the onset of injury through the cell death period. This phase can last from hours to days and is characterized by:Renal flow at 25% of normalOxygenation to the tissue at 25% of normalUrine output at 30 ml (or less) per hourUrine sodium excretion greater than 40 mEq/L.In this phase only 50% of the patients are noted to be oliguric. With prompt treatment, irreversible damage can be achieved during this pre renal failure onset phase.
8The Four Phases of Acute Renal Failure Oliguric/Anuric Phase – this phase usually lasts between 8-14 days and is characterized by further damage to the renal tubular wall and membranes. Other characteristics in the oliguric- anuric phase include:Great reduction in the glomerular filtration rate (GFR)Increased BUN/CreatinineElectrolyte abnormalities (hyperkalemia, hyperphosphatemia and hypocalcemia)Metabolic acidosis
9The Four Phases of Acute Renal Failure Diuretic Phase – this phase occurs when the source of obstruction has been removed but the residual scarring and edema of the renal tubules remains. This phase usually lasts and additional days and is characterized by:Increase in glomerular filtration rate (GFR)Urine output as high as 2-4 L/dayUrine that flows through renal tubulesRenal cells that cannot concentrate urineIncreased GFR in this phase contributes to the passive loss of electrolytes which requires the administration of IV crystalloids to maintain hydration.
10The Four Phases of Acute Renal Failure Recovery Period Phase – The recovery phase can last from several months to over a year. During this phase, edema decreases, the renal tubules begin to function adequately and fluid and electrolyte balance are restored (if damage was significant, BUN and Creatinine may never return to normal levels). At this point the GFR has usually returned to 70% to 80% of normal.
11Symptoms and SignsThe signs and symptom that may be experienced with ARF depend onPhase, degree of azotemia (abnormal levels of urea and creatinine) and degree of metabolic acidosisThe following signs and symptoms are consistent with ARF:Decreased urine output (urine may be pink or reddish in color)Edema (face, arms, legs, feet eyes)Flank pain/Pelvic painPoor appetite (nausea, vomiting)Bitter or metallic taste in mouth
12Symptoms and Signs Symptoms and signs (Contd) Dry itchy skin Easy bruisingFatigueSeizures/LOCShortness of breathArrhythmiasSudden weight gain
14Diagnosing ARF More about BUN and Creatinine Although elevated levels BUN/Creatinine are considered to be the “hallmarks” of acute renal failure, the rate of rise is actually dependant on the degree of renal ischemia and injury and in regards to BUN; the rate of protein uptake.BUN may also be elevated in other conditions not directly related to acute renal failure such as; GI or mucosal bleeding, steroid treatment therapy or protein loading.
16Medical Management of Acute Renal Failure Medical management of acute renal failure must focus on first identifying and treating the causeMaintaining volume homeostasis and correcting biochemical abnormalities remain the primary goals of treatment.Gathering a detailed patient history (pre-hospital and current)Maintaining adequate intravascular volumeMaintaining mean arterial pressureDiscontinuing all nephrotoxic medications (NSAIDS, Gentamycin)Eliminating exposure to any other nephrotoxins
17Medical Management of Acute Renal Failure Correcting acidosis (sodium bicarbonate for severe acidosis)Correcting hemolytic abnormalities (blood transfusion may be required)Correcting all electrolyte abnormalities (Hyperkalemia is very common)Strict monitoring on intake and output/daily weight (Hydration for prerenal failure)Serial monitoring of labs (BUN/Creatinine/Osmolality [urine/blood], etc)Diet and fluid restrictions/replacement (in a state of oliguria or polyuria)
18Medical Management of Acute Renal Failure Dialysis: (a short term intervention when fluids and electrolytes cannot be managed by other means). This may involve the use of any of the following three methods:Peritoneal Dialysis – peritoneal dialysis is not commonly used as a treatment with acute renal failure. Although efficient, it is slow process that involves the transfer of fluid and solutes between the peritoneal cavity and the peritoneal capillaries. The clearance that occurs with peritoneal dialysis is thought to be less effective than other types of dialysis.
19Medical Management of Acute Renal Failure Hemodialysis – hemodialysis remains the primary method of renal replacement therapy in patients with acute renal failureProvides ultrafiltration for rapid water removal and diffusion for solute removalIndicated for uremia, electrolyte imbalances, fluid overload and severe metabolic acidosisRecommended when there is a need for quick removal of water and toxinsOne concern with using hemodialysis for critically ill patients with acute renal failure is that the process requires moving large amounts of fluid out of the intravascular system which can lead to acute and severe hypotension (secondary to hypovolemia).
20Medical Management of Acute Renal Failure Continuous Renal Replacement Therapy (CRRT) – CRRT therapy works similarly to hemodialysis except it is a continuous ongoing process that is less likely to cause acute hypotension. Other benefits to using CRRT as a method of dialysis include:Hemodynamic stabilityCorrection of metabolic acidosisQuicker kidney recovery timeCorrection of malnutritionSolute removal
21Pharmaceutical Interventions Furosemide (Lasix) – a loop diuretic that can be used to increase urinary flow with the intent of flushing out cellular debris that may be causing an obstruction.Mannitol – an osmotic diuretic that can be used to dilate renal arteries by increasing the synthesis of prostaglandins (resulting in restored renal flow).
22Pharmaceutical Interventions Dopamine – at low doses (1-5 mcg/kg/min), dopamine dilates renal arterioles and increases renal blood flow and glomerular filtration. Because dopamine (even at low doses) can cause tachycardia, myocardial ischemia and arrhythmias it use should be considered carefully.N-acetylcysteine – this medication can help reverse acute renal failure when the cause is thought to be from a nephrotoxic source.
23Nursing Care and Management Because acute renal failure often progresses through four phases, it is important for the nurse to detect which phase of failure the patient is experiencing in order to develop an appropriate plan of careA detailed history should be obtained to help direct nursing care; this history should include the following information:History of chronic illness (hypertension, diabetes)Recent infections (especially those that may have been streptococcal in nature)Recent episodes of hypotension (from surgery or bleeding)Exposure to nephrotoxins or chemical agentsRecent blood transfusions
24Nursing Care and Management Contd…Recent urinary tract disordersToxemia from pregnancy or abortionRecent severe muscle damageRecent burn trauma
25Nursing Care and Management Nursing assessment and subsequent interventions should focus around the following physical findings (based on the phase of renal failure):Onset Phase:Mild reduction in normal daily urine outputMild lethargyMild malaise
26Nursing Care and Management Oliguric/Anuric Phase:24 hour urine total 400 ml or lessListlessness/fatigueConfusion or altered LOC (from electrolyte imbalances)ECG changes (elevated T waves, depressed ST segment, prolonged PR interval, loss of P wave, wide QRS complex, arrhythmias)S3 or S4 gallopPericardial friction rubPulsus paradoxusFeverChest painCrackles upon lung auscultation (due to fluid overload)Shortness of breath (due to fluid overload)
27Nursing Care and Management Oliguric/Anuric Phase:Jugular vein distention (due to fluid overload)Periorbital, peripheral or sacral edema (due to fluid overload)Ascites (due to fluid overload)Capillary fragility as evidenced by easy bruisingMetabolic acidosisAnorexia, nausea, vomiting, diarrhea, constipationUremic frost (pale, yellow, dry or itchy skin)Diuretic Phase:Urine output of 3 to 5 liters in a 24 hour periodLethargy or muscle weakness (due to hypokalemia)Decreased blood pressure (due to fluid depletion)Dry mucous membranes (due to fluid depletion)Poor skin turgor and delayed capillary refill (due to fluid depletion)
28Nursing Care and Management Recovery Phase:Urine output of 1500 to 1800 ml in a 24 hour periodStabilization of serum potassium, bicarbonate, BUN and creatinineStabilization of cardiac rhythm and rateReduction in lethargy and shortness of breathReduction in adventitious breath sounds
29Nursing Responsibilities for CRRT Patient family teaching regarding the procedure and equipmentMonitoring of hemodynamic stabilityFrequent observation of the patients response to fluid removalContinuous assessment of vital signs/CVP/PAWP/PAP/Cardiac OutputMonitoring changes in mental statusAssessing breath soundsAssessing skin turgor/edemaMonitoring for signs of bleeding/infection
30Nursing Responsibilities for CRRT Monitor specifically for hypotension in response to hypovolemia (aggressive fluid replacement with a crystalloid and/or alteration of the ultrafiltration rate may be necessary).Monitoring for fluid volume overload (requiring a decrease or temporary discontinuation of replacement fluid).Monitor that all equipment connections are secure (due to the risk for vast hemorrhage if a break in the system occurs).
31Nursing Responsibilities for CRRT Close monitoring of electrolyte and acid-base imbalances (prompt replacement is required).Adjusting care based on the mobility restrictions that occur with CRRT equipment.Close monitoring of extremity distal to catheter placement (pulses/perfusion).Assessment of catheter insertion site/dressing changes as per policy.
32Appropriate Nursing Diagnosis for Consideration Alteration in urinary elimination(the goal is that the patient is euvolemic and has no symptoms suggestive of fluid deficit or overload).Fluid volume deficit(the goal is that the patient is euvolemic; with urine output that is approximately 30 ml/hr and has no symptoms suggestive of fluid deficit i.e. dry mouth, hypotension, poor skin turgor, delayed capillary refill).Fluid volume overload(the goal is that the patient is euvolemic and has no symptoms suggestive of fluid overload such i.e. edema, wt. gain, JVD).Altered nutrition(less than bodily requirement) - (the goal is that the patient will have balanced nutrition and fluid balance with weight within normal limits).
33Appropriate Nursing Diagnosis for Consideration Potential for impaired skin integrity(the goal is that the patient remains free from pressure ulcers and dry itchy skin).Knowledge deficit(the goal is that the patient/family has a better understanding of the disease process and understand the need for follow up care).Decreased cardiac output(the goal for the patient is to have improved clinical findings based on adequate cardiac output i.e. normal vital signs, adequate capillary refill, absence of hypotension)Fear (anxiety)(the goal for the patient will have a low level of anxiety and be able to effectively express concerns and questions regarding care. The patient will also be able to verbalize symptoms of anxiety and mechanisms for dealing with these symptoms).
34Appropriate Nursing Diagnosis for Consideration Potential for impaired skin integrity(the goal is that Activity intolerance - (the goal for the patient is to participate in activities of daily living without become exhausted).Ineffective individual/family copingthe goal of the patient/family is to be able to participate in care without becoming overwhelmed. The goal is also to be able to verbalize where counseling/support can be found i.e. American Association of Kidney Patients or the National Kidney Foundation for example).Body image disturbance(the goal of the patient who may require a shunt for hemodialysis is to state or demonstrate acceptance of this change).
35Appropriate Nursing Diagnosis for Consideration Altered thought processes(the goal of the patient is to demonstrate improved cognitive function and be able to participate in activities of daily living).Potential for injury(the goal for the patient is to remain injury free and be able to verbalize and explain methods to prevent injuries and/or falls).Risk of infection(the goal for the patient is to remain free from symptoms of infection (WBC’s within normal limits) and to be able to state what symptoms of infection are).