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Evaluation and Medical Management of Vulvar Dermatoses Katherine “Casey” Monahan, FNP-C, Dermatology Providence Little Co. of Mary Dermatology & Laser.

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Presentation on theme: "Evaluation and Medical Management of Vulvar Dermatoses Katherine “Casey” Monahan, FNP-C, Dermatology Providence Little Co. of Mary Dermatology & Laser."— Presentation transcript:

1 Evaluation and Medical Management of Vulvar Dermatoses Katherine “Casey” Monahan, FNP-C, Dermatology Providence Little Co. of Mary Dermatology & Laser Center

2 Types Dermatitis – acute inflammation Contact dermatitis Dermatoses – chronic inflammation Lichen simplex chronicus Lichen sclerosus Lichen planus

3 History Specific areas to address include: Major complaints Hygienic practices Types of clothing Medications Personal and family history Sexual history

4 Physical Examination & Diagnostics Inspect the entire vulvar and perianal area with good lighting Inspect the mouth Swabs for microbiology Skin biopsy Patch testing

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6 Exogenous (Contact) Dermatitis Vulvar dermatitis (eczema) – the most common vulvar dermatosis Two types of contact dermatitis Allergic (20% of cases) Irritant (80% of cases)

7 Contact Dermatitis Vulvar tissue more permeable than exposed skin Typically, allergens are new exposures Allergic reactions require prior exposure to a product Irritants cause an immediate response, whereas allergic reactions occur 12 to 72 hours after exposure

8 Contact Dermatitis Signs and Symptoms Redness, swelling, and scaling of the labia minora Superficial fissures Pain and burning at rest Introital dyspareunia Generalized pruritus less common

9 Contact Dermatitis

10 Allergens Fragrances, preservatives, topical medications, and rubber Propylene glycol Irritants Anti-fungal, anti-bacterial, and steroidal creams/ointments Preservatives, stabilizers, and delivery vehicles in drugs, as well as the drugs themselves

11 Contact Dermatitis Irritants Soaps Bubble baths Baby wipes Talcum powder Urine Feces Deodorants Sanitary protection Allergens Benzocaine Chlorhexidine Perfume Neomycin Nickel Nail polish Latex Spermicides

12 Contact Dermatitis Management Identify and eliminate causative agent(s) Replace all known irritant agents with hypoallergenic moisturizing preparations Local measures Oatmeal colloidal soaks Ice packs Mild steroidal ointment in petroleum Aqueous 4% Xylocaine solution

13 Contact Dermatitis

14 Lichen Simplex Chronicus (“LSC”) Occurs in chronic cases of dermatitis, resulting from rubbing and scratching Characterized by skin lichenification and excoriation, together with pigmentary abnormalities Accentuation of skin lines/markings Leathery texture

15 LSC

16 Management Goal: cessation of pruritus Avoid scratching High-potency steroid cream/ointment initially, then medium- to lower-strength topical steroids Occlusion of medium-potency steroids Intralesional kenalog injections (5 – 10mg/ml) Unna boot

17 Lichen Sclerosus Lichen Sclerosus et Atrophicus (“LS&A”) Most common vulvar dermatosis/disease Chronic, inflammatory, autoimmune disease of the skin and mucosae, preferentially affecting the vulva Most common among post-menopausal women (up to age 90 yrs.); females predominately May affect children (from age 5 mos.) and young adults If untreated, can result in fusion around the clitoris (phimosis), atrophy and splitting of the vestibule, severe narrowing of the vaginal orifice, and, rarely, vulvar cancer (squamous cell carcinoma (“SCC”))

18 LS&A Signs Atrophy White patches surrounded by erythematous or violaceous halos Lesions may coalesce into large atrophic erosions, making the skin smooth, wrinkled, soft, and white Excoriations or superficial fissures *characteristic signs that help distinguish LS&A *

19 LS&A Signs Thickened areas Vulvar and perineal involvement leads to “figure-eight” or “hourglass” shape around the anus Obliteration of architecture with loss of labia minora, clitoral hood, and urethral meatus Labial stenosis or fusion

20 LS&A

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22 Symptoms – mean duration 99 months Intense pruritus Soreness Burning Dyspareunia

23 LS&A Management Biopsy Clobetasol ointment = drug of choice Effective in 90% of patients with reversal of epidermal atrophy

24 LS&A Refractory/Severe Cases Cortisone injections Oral retinoid therapy and topical tretinoin Maintenance with testosterone ointment and progesterone cream Surgery rarely indicated

25 Lichen Planus Chronic, inflammatory, autoimmune disease involving: Glabrous skin (flexor surfaces of arms and legs) Hair-bearing skin and scalp Nails Mucous membranes of the oral cavity and vulva >70% of patients between the ages of 30 and 60 years

26 Lichen Planus Vulvo-vaginal-gingival syndrome: involves vulva and vagina with gingivitis Oral lesions may precede or follow vulvovaginal lesions by months or years or may be simultaneous Vaginal mucosa involved in two-thirds of cases In one-third of cases, reticulate buccal involvement 10% have concurrent cutaneous lesions

27 Lichen Planus Vulvovaginal signs Rarely presents as the classic widespread shiny, violaceous, pruritic, flat-topped papules Erosive/ulcerative form most common presentation in mucous membranes Mucosal: white reticulate or lace-like changes (Wickham’s striae) or erosions Vulvar: erythematous erosions with narrow rim of white reticulation Vaginal: glazed erythema, easy friability

28 Lichen Planus Vulvovaginal symptoms Pruritus on hair-bearing vulvar skin Severe burning pain in the vestibule or vagina

29 Lichen Planus May be subtle and mistaken for vulvodynia Typically, morphology similar to vulvar lichen sclerosus Late scarring with loss of labia minora and clitoral hood Adhesion formation in upper part of vagina Total vaginal obliteration Erosive mucosal cases considered pre-malignant

30 Lichen Planus

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35 Management Biopsy: histological evaluation superior to direct immunofluorescence Topical and/or intravaginal steroid = first-line therapy

36 Lichen Planus Vulvar management Clobetasol or another high-potency topical steroid ointment BID Long-term maintenance with low or mid-potency topical steroid ointment Calcineurin inhibitors: tacrolimus (Protopic) and pimecrolimus (Elidel) cream BID or suppository QHS Oral hydroxychloroquine (Plaquenil), cyclosporine, azathioprine (Imuran), etanercept (Enbrel), methotrexate

37 Lichen Planus Vaginal management Anusol hydrocortisone suppositories Vaginal dilation Surgery


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