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Principles of Immunology Overview of Innate Immunity 1/19/06 “Education is not preparation for life. Education is life itself.” John Dewey.

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Presentation on theme: "Principles of Immunology Overview of Innate Immunity 1/19/06 “Education is not preparation for life. Education is life itself.” John Dewey."— Presentation transcript:

1 Principles of Immunology Overview of Innate Immunity 1/19/06 “Education is not preparation for life. Education is life itself.” John Dewey

2 Review(T/F)  Jenner was the first to introduce variolation  Innate immune responses are specific  T cells are either T-helper or T- cytotoxic cells  Immunological memory results in an amanestic response  All antigens are immunogens

3 Innate Immunity  Nonspecific host defenses that exist prior to exposure to an antigen. Involves the following components: Anatomic Physiologic Phagocytic Inflammatory

4 Word List  Antibody  Antigen  Complement  Endocytosis  Humoral  Macrophage  Monocyte  Neutrophil

5 Barriers to Antigenic Insult  Anatomic Skin Mucous membranes  Physiologic Temperature pH Chemical mediators

6 Cellular and Inflammatory Components of Innate Immunity  Cellular Phagocytic cells  Inflammatory Vasodilation Capillary permeability

7 Anatomic Barriers  Skin Epidermis Dermal layer Sebaceous glands Normal flora

8 Anatomic Barriers  Mucous membranes Physical barrier Secretions Cilia Normal flora

9 Physiologic Barriers  Temperature Varies by species Febrile response  Endogenous pyrogens  pH Skin GI tract

10 Physiologic Mediators of Innate Immunity  Chemical mediators Enzymes Interferon Complement  Three pathways Classical MB Lectin Alternative

11 Physiologic Mediators of Innate Immunity(cont’d)  Chemical mediators Collectins Toll-like receptors Acute phase proteins

12 Cellular Component of Innate Immunity  Phagocytic cells Monocytes Neutrophils Macrophages  Non-Phagocytic cells Natural killer cells

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14 Inflammatory Response  Hallmarks of inflammation Rubor Tumor Calor Dolor  Primary cell Activated macrophage

15 Inflammatory Response(cont’d)  Biological effects Vasodilation Capillary permeability Phagocyte migration

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17 Inflammatory Response(cont’d)  Chemical mediators of inflammation Histamine Kinin system Fibrin system

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