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Syncope Victoria E Judd. Disclosure Slide Nothing to disclose.

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Presentation on theme: "Syncope Victoria E Judd. Disclosure Slide Nothing to disclose."— Presentation transcript:

1 Syncope Victoria E Judd

2 Disclosure Slide Nothing to disclose

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4 Objectives Define syncope Discuss the different types List treatments

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6 Syncope Is the abrupt and transient loss of consciousness associated with absence of postural tone followed by complete and usually rapid spontaneous recovery

7 Syncope alarming for the individual, witnesses, family, and providers most often benign and self-limited a harbinger of a multitude of disease processes injuries resulting from syncopal attacks occur in about one-third of patients recurrent episodes can be psychologically devastating can be a premonitory sign of cardiac arrest, in patients with organic heart disease

8 Syncope

9 Case A 22 year old female standing in line at the bookstore passed out. She said she got lightheaded, hot and then remembers waking up on the floor. A bystander said she was out less than a minute. She also tried to grab onto something as she was going down. She was pale. She was not confused after the event.

10 Case Oriented HR 66, RR 16, BP 95/62 HEENT normal CV normal Neuro Normal

11 Reflex/Vasovagal Syncope Mediated by emotional distress: fear, pain, instrumentation, blood phobia Mediated by orthostatic stress

12 Situational Syncope Cough, sneeze Gastrointestinal stimulation (swallow, defecation, visceral pain) Micturition (postmicturation) Post-exercise Postprandial Others (e.g., laughter, brass instrument playing, weightlifting) Carotid sinus syncope Combing hair

13 Syncope Due to Orthostatic Hypotension Primary autonomic failure: Pure autonomic failure, multiple system atrophy, Parkinson's disease with autonomic failure, Lewy body dementia Secondary autonomic failure: Diabetes, amyloidosis, uremia, spinal cord injuries Drug-induced orthostatic hypotension: Alcohol, vasodilators, diuretics, phenothiazine's, antidepressants Volume depletion: Hemorrhage, diarrhea, vomiting, etc.

14 Cardiac Syncope Arrhythmia as primary cause: Bradycardia: Sinus node dysfunction (including bradycardia/tachycardia syndrome) Atrioventricular conduction system disease Implanted device malfunction Tachycardia: Supraventricular Ventricular (idiopathic, secondary to structural heart disease or to channelopathies) Drug-induced bradycardia and tachyarrhythmias

15 Cardiac Syncope Structural disease: Cardiac: cardiac valvular disease, acute myocardial infarction/ischemia, hypertrophic cardiomyopathy, cardiac masses (atrial myxoma, tumors, etc.), pericardial disease/tamponade, congenital anomalies of coronary arteries, prosthetic valves dysfunction Others: pulmonary embolus, acute aortic dissection, pulmonary hypertension

16 Causes of Syncope ■ Reflex (neurally-mediated; this includes vasovagal, POTS) — 58 percent ■ Cardiac disease, most often a bradyarrhythmia or tachyarrhythmia — 23 percent ■ Neurologic or psychiatric disease — 1 percent ■ Unexplained syncope — 18 percent; a higher value (41 percent) was noted in another large series

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23 The initial evaluation should answer three key questions ■ Is it a syncopal episode or other type of event? ■ Has the etiology been determined? ■ Is there evidence suggestive of a high risk of cardiovascular events or death?

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25 Case A 21 year old male college student was running across campus to get to class. He fainted. He remembers no symptoms prior to collapse. He remembers getting up and walked to student health. Bystanders told him he was not out very long. No illnesses. No medications. Normal exam.

26 ECG: LVH with “strain” pattern

27 Case Syncope without warning is likely cardiac.

28 If Yes, Then Syncope ■ Was loss of consciousness complete? ■ Was loss of consciousness transient with rapid onset and short duration? ■ Did the patient recover spontaneously, completely and without sequela? ■ Did the patient lose postural tone?

29 Recurrent Syncope The number of syncopal episodes can predict the risk of recurrence.

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31 Clinical features that suggest a diagnosis on initial evaluation Reflex/Neurally mediated syncope: Absence of heart disease Long history of recurrent syncope After sudden unexpected unpleasant sight, sound, smell or pain Prolonged standing or crowded, hot places Nausea, vomiting associated with syncope During a meal or post-prandial With head rotation or pressure on carotid sinus (as in tumors, shaving, tight collars) After exertion

32 Clinical features that suggest a diagnosis on initial evaluation Syncope due to Orthostatic Hypotension(OH): After standing up Temporal relationship with start or changes of dosage of vasodepressive drugs leading to hypotension Prolonged standing especially in crowded, hot places Presence of autonomic neuropathy or Parkinsonism Standing after exertion

33 Clinical features that suggest a diagnosis on initial evaluation Cardiovascular syncope: Presence of definite structural heart disease Family history of unexplained sudden death or channelopathy (i.e. Long QT) During exertion, or supine Abnormal ECG Sudden onset palpitation immediately followed by syncope

34 Cardiovascular syncope: - Non-sustained VT - Pre-excited QRS complexes - Long or short QT intervals - Early repolarization - RBBB pattern with ST-elevation in leads V1-V3 (Brugada syndrome) - Negative T waves in right precordial leads, epsilon waves and ventricular late potentials suggestive of ARVC - Q waves suggesting myocardial infarction

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39 History "Auras" are associated with seizures. In comparison, reflex (vasovagal) syncope is usually, but not always, associated with a prodrome of nausea, warmth, pallor, lightheadedness, and/or diaphoresis. Sudden onset of syncope without a prodrome is more common among patients with cardiac syncope (arrhythmic or mechanical cardiac etiology).

40 History Reflex syncope commonly occurs when the patient is erect, not usually when supine. Syncope resulting from orthostatic hypotension is frequently associated with the change from a supine/sitting to erect posture. In comparison, syncope that occurs when the patient is supine suggests an arrhythmia.

41 History An evaluation to rule out potentially life- threatening causes for syncope is required if syncope occurs during exertion

42 History A prolonged loss of consciousness may indicate a seizure. By comparison, arrhythmias and reflex syncope are often associated with a brief period of syncope, since the supine position reestablishes some blood flow to the brain and can therefore result in the restoration of consciousness. Recovery of consciousness may occur even if the arrhythmia is maintained.

43 History Persistence of nausea, pallor, and diaphoresis in addition to a prolonged recovery from the episode suggest a reflex event. These findings are helpful in distinguishing reflex syncope from syncope due to an arrhythmia. Significant neurologic changes or confusion during the recovery period may be due to a stroke or seizure.

44 History A witness to the syncopal event may verify the loss of consciousness, any associated limb movements, and the presence or absence of pallor, diaphoresis, or a pulse. Reflex syncope is more likely to occur among young, otherwise healthy patients.

45 History Important elements of the family history include history of sudden death, pacemakers in young people, syncope, seizures, single car accidents, drowning, cardiomyopathy.

46 History Seizures are the probable cause of very few percent of apparent syncopal episodes. They can mimic syncope when the seizure is atypical and not associated with tonic-clonic movements, the seizure is not observed, or a complete history cannot be obtained. Some patients with syncope present with myoclonic or other involuntary movements that are suggestive of a seizure but are actually due to cerebral hypoxia.

47 History One distinguishing feature is that patients with seizures rarely have a rapid and complete recovery. Instead, the postictal state is characterized by a slow and complete recovery. Another feature is usually those with syncope are pale and those with seizures are usually flushed.

48 Physical Exam Blood pressure obtained in the supine, sitting, and erect position may detect orthostatic hypotension.

49 Orthostatic Measurement Orthostatic blood pressure measurement is performed with the patient standing after at least three minutes of lying supine. Blood pressure should be measured each minute (or more often) in the standing position for three minutes or more (or as long as the patient tolerates) until the blood pressure nadir is reached. A sphygmomanometer (manual blood pressure cuff) may allow greater flexibility than an automatic arm-cuff device in measuring blood pressure prior to and during active standing

50 Orthostatic syndromes ■ Classic orthostatic hypotension (OH) is defined as a decrease in systolic blood pressure (BP) of ≥20 mmHg and in diastolic BP ≥10 mmHg within three minutes of standing. This syndrome is diagnosed by active standing. ■ Initial OH is defined by a BP decrease immediately on standing of >40 mmHg with BP spontaneously and rapidly returning to normal, so the period of hypotension and symptoms is <30 s. This is diagnosed by active standing.

51 Orthostatic syndromes ■ Postural orthostatic tachycardia syndrome (POTS) presents with severe orthostatic intolerance (not syncope) with marked increase in heart rate (by >30 beats per minute or to >120 beats per minute) within ten minutes of standing. This is diagnosed by tilt table or passive standing. POTS can be diagnosed with bedside measurements of heart rate and blood pressure taken in the supine and standing up position at 2, 5 and 10 minute intervals. In children and adolescents, a revised standard of a 40 bpm or more increase has recently been adopted.

52 Physical Exam The heart rate may be rapid or slow due to a number of possible rhythm disturbances, or irregular due to atrial fibrillation. The pulse and blood pressure should be obtained with the patient supine, seated, and erect. Hyperventilation can be seen with pulmonary embolism or psychiatric causes of syncope.

53 Physical Exam The cardiac examination may reveal the murmur of aortic stenosis or mitral stenosis. Pulmonary hypertension may be suggested by a loud, palpable P2. Increase in an outflow (systolic ejection) murmur with the Valsalva maneuver may help diagnose hypertrophic cardiomyopathy.

54 Physical Exam Unilateral abnormalities found upon neurologic examination may reflect a cerebral vascular accident.

55 ECG An electrocardiogram (ECG) should be obtained in all patients with syncope. The ECG is suggestive of an arrhythmic cause of syncope if any of the following abnormalities is present: ■ Bifascicular block (defined as left bundle branch block or right bundle branch block combined with left anterior or left posterior fascicular block) ■ Other intraventricular conduction abnormalities (QRS duration ≥0.12 sec) ■ Mobitz II second degree atrioventricular block

56 ECG ■ Asymptomatic sinus bradycardia (<50 beats/min), sinoatrial block or sinus pause ≥3 seconds in the absence of negatively chronotropic medications ■ Preexcited QRS complexes, suggesting Wolff- Parkinson-White syndrome ■ Long or short QT intervals ■ Right bundle branch block pattern with ST-elevation in leads V1-V3 (Brugada syndrome) ■ Negative T waves in right precordial leads, epsilon waves and ventricular late potentials suggestive of arrhythmogenic right ventricular cardiomyopathy ■ Q waves suggesting myocardial infarction

57 Testing Additional testing is based on the results of the initial evaluation. A variety of tests, mostly cardiologic, can be used in the evaluation of the patient with syncope. Neurologic testing is generally of low yield and overused, unless specifically suggested by history or physical examination. ■ Carotid sinus massage in patients >40 years old. ■ Echocardiogram when there is previous known heart disease or data suggestive of structural heart disease or syncope secondary to cardiovascular cause.

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60 Case An 18 year old female has had syncopal episodes for 3 years. They occur about twice a year. She has needed stitches and had a broken arm. She feels like she going to faint before each episode. Her family history is negative. Her exam is normal. Her ECG is normal.

61 Implantable Loop Recorders (ILR) ILR Patient Assist Device Automatically detects bradycardia bradycardia tachycardia tachycardia asystole asystole Records rhythm at time of trigger time of trigger

62 Example tracing from ILR

63 ILR in unexplained syncope with normal conventional work-up Tachycardia 56% 11% 33% Asystole / bradycardia No arrhythmia Diagnostic yield: 35% (175/506 patients) Brignole et al. Europace 2009;11,

64 Testing Neurologic tests, including electroencephalogram (EEG), brain CT, brain magnetic resonance imaging, and carotid Doppler ultrasound, are frequently obtained in patients with syncope. In one review of 649 patients, 53 percent had at least one neurologic test. However, such testing was rarely useful.

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66 Postural Orthostatic Tachycardia Syndrome (POTS) A form of orthostatic intolerance occurs in patients, particularly younger adults and children, who consistently or frequently experience symptoms of orthostatic intolerance in response to postural stressors. Autonomic reflexes are relatively preserved in these patients, and orthostatic hypotension and syncope rarely occur. Some patients may have slightly elevated blood pressure. The hallmark of this disorder is an exaggerated heart rate increase in response to postural change.

67 Names of POTS ■ Chronic orthostatic intolerance ■ Mild orthostatic intolerance ■ Orthostatic tachycardia ■ Sympathotonic orthostatic hypotension ■ Hyperdynamic beta adrenergic state ■ Idiopathic hypovolemia ■ Mitral valve prolapse syndrome ■ Neurocirculatory asthenia ■ Irritable heart ■ Soldier's heart ■ Effort syndrome

68 Facts POTS It is the most prevalent form of orthostatic intolerance. It is estimated that 500,000 Americans suffer from this disorder. It is the most common syndrome of young people seen in autonomic dysfunction clinics. Patients present at a relatively young age (14 to 45 years).

69 Facts POTS Women predominate among patients with POTS with a female to male ratio of 4-5:1.

70 Etiology POTS The etiology of postural tachycardia syndrome (POTS) is heterogeneous. Investigators have reported a number of different abnormalities in patients with POTS. It remains uncertain as to which of these abnormalities are primary and causative and which are secondary.

71 Etiology POTS Hypovolemia — Patients with POTS frequently experience symptomatic improvement with saline infusion. Additional evidence of a decrease and/or redistribution of blood volume is observed in several studies of patients with POTS, which have noted: ■ Hypovolemia ■ Trend toward hypovolemia ■ Reduced erythrocyte volume ■ Excessive venous pooling with redistributive hypovolemia

72 Clinical POTS Patients with postural tachycardia syndrome (POTS) report dizziness, lightheadedness, weakness, blurred vision, and fatigue upon standing. Other predominantly orthostatic symptoms include palpitations, tremulousness, and anxiety.

73 Clinical POTS Gastrointestinal symptoms such as nausea, abdominal cramps, early satiety, bloating, constipation, and diarrhea may be particularly problematic in some. There may also be evidence of venous pooling, as manifested by acrocyanosis and edema when upright. Syncope is relatively unusual, but does occur in about 40 percent of patients.

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75 Clinical POTS The onset often follows a flulike illness. Illness may occasionally represent a self- limited autoimmune disease. The role of immune and genetic factors remains ill defined. Some patients have an insidious onset over years, sometimes with a past history of reflex syncope.

76 Clinical POTS Patients are unable to remain upright for long periods of time. Symptoms are similar to the prodrome of reflex syncope. BP is typically well maintained and may increase when upright in hyperadrenergic individuals. A tilt test may provoke reflex syncope.

77 Clinical POTS Cognitive deficits and exercise intolerance are prominent complaints. Gastrointestinal symptoms include dysmotility issues. Young women may be underweight, and POTS must be differentiated from eating disorders, which can produce POTS-like Orthostatic Intolerance in early stages.

78 Clinical POTS Environmental heat reroutes blood to the skin and makes patients worse. Air-conditioning may be required and standing hot showers untenable. Schoolwork may be impaired. Home schooling is common in adolescents. Colleges are often accommodating because of adaptive scheduling and improved logistics.

79 Clinical POTS Some patients experience only mild symptoms and often only in the setting of additional orthostatic stress (e.g., menstrual cycle, relative dehydration). Others are profoundly incapacitated. The course of the disorder may be self limited or may follow a relapsing remitting course over several years.

80 Diagnosis POTS The characteristic autonomic abnormality in patients with postural tachycardia syndrome (POTS) is an exaggerated increase in heart rate on tilt table testing or standing. Diagnostic criteria from several laboratories have in common a sustained heart rate increase of greater than 30 beats per minute or an increase to 120 beats per minute or greater within the first 10 minutes of tilt. There is usually no orthostatic hypotension.

81 Diagnosis POTS Autonomic neuropathies, central dysautonomias, bed rest deconditioning, side effects of medications, and dehydration can produce similar symptoms to POTS. Ruling out these conditions is essential to making a diagnosis of POTS. In most cases, historical information and a neurologic examination specifically looking for other evidence of autonomic failure, neuropathy, and extrapyramidal signs, will provide evidence of the underlying disorder.

82 Diagnosis POTS Patients with POTS may be thought to have panic, anxiety, somatization disorder, or chronic fatigue syndrome in part because of the vague nature of the symptoms. In fact, patients with POTS report subjective cognitive dysfunction and have objectively increased scores on inattention scales, but do not have an increased prevalence of depression or anxiety. The prominent postural nature of the symptoms should prompt the clinician to look for the diagnostic heart rate response.

83 Diagnosis POTS The syndrome of inappropriate sinus tachycardia is characterized by an elevated heart rate that is not influenced by postural changes.

84 Treatment POTS The optimal therapy of postural tachycardia syndrome (POTS) is uncertain. No intervention has been systematically studied. The placebo effect may be substantial in POTS, highlighting the need for controlled studies. Exacerbating factors, medications, dehydration, and inactivity should be avoided.

85 Treatment POTS Because many patients with POTS have a low plasma volume, correction with oral volume expansion, a high salt diet (3,000 mg to 10,000 mg per day), and fludrocortisone, a mineralocorticoid agonist may improve symptoms. This regimen is similar to that used in orthostatic hypotension in general.

86 Volume Expansion Fludrocortisone mg daily – Many patients with POTS are hypovolemic, so fludrocortisone (an aldosterone analogue) is often used. Through enhanced renal sodium retention, it should expand the plasma volume (although the data are poor). Potassium wasting can result in hypokalemia, so serum K+ should be monitored periodically.

87 Sympatholysis Propranolol mg PO QID – Many patients report intolerance to beta blockers when first seen at the Vanderbilt Autonomic Dysfunction Center. The vast majority of POTS patients, however, respond well hemodynamically and symptomatically to low doses of propranolol. Of note, more complete beta blockade with higher doses of propranolol cause symptoms to worsen. Long acting propranolol was not found to be helpful.

88 Sympatholysis Methyldopa 125mg QHS-BID – Methyldopa is a false neurotransmitter that can lower central sympathetic tone. It is particularly useful in hyperadrenergic patients. Clonidine mg PO BID (or a long acting patch) - Alpha 2 adrenergic agonist that acts centrally to decrease sympathetic nervous system tone. It can stabilize HR and BP, but it can also cause drowsiness, fatigue and worsen the mental clouding of some patients.

89 Vasoconstrictor Therapy Midodrine 5-10mg PO q4H x3/day - Since a failure of vascular resistance may be an integral part of neuropathic POTS, vasoconstrictors such as midodrine (alpha-1 agonist) can be employed.

90 Increasing Vagal Tone Pyridostigmine mg PO TID – Pyridostigmine is a peripheral acetylcholinesterase inhibitor. By increasing synaptic acetylcholine at both the autonomic ganglia and the peripheral muscarinic parasympathetic receptors, pyridostigmine significantly restrains the heart rate in response to standing in patients with POTS. Pyridostigmine is most effective in combination with low dose propranolol. Since pyridostigmine enhances bowel motility, it is often not well tolerated in patients with diarrhea-predominant irritable bowel syndrome symptoms.

91 Figure. Treatment strategies for POTS. Grubb B P, and Karabin B Circulation. 2008;118:e61-e62 Copyright © American Heart Association, Inc. All rights reserved.

92 POTS Treatment One confounding and alarming issue is the tendency for POTS patients to bed rest. Prolonged bed rest emulates microgravity and has deleterious effects including Orthostatic Instability (OI) profound reductions in blood volume and cardiac size, redistribution of blood, osteoporosis, skeletal muscle pump atrophy, and more. Vasoconstriction is impaired. Bed rest causes a self-perpetuating state of Orthostatic Intolerance, which can emulate or intensify POTS.

93 POTS Treatment It is paramount for POTS patient to leave bed and recondition. Well-structured exercise protocols are essential and must accommodate patients who start off bed rested. Reconditioning invariably improves patient well-being. Recent work supports the idea that POTS patients are also exercise deconditioned compared with matched volunteers. Although exercise deconditioning may or may not be causal in POTS, it is clear that exercise reconditioning is beneficial and should be advocated for all POTS patients.

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95 Reflex Syncope Upright posture causes pooling of blood in lower extremities Decrease in venous return causes transient hyperdynamic ventricle Cardiac C fibers (mechanoreceptors) activate causing parasympathetic response resulting in bradycardia, peripheral vasodilation and hypotension Abrupt decrease in BP and HR ± asystole

96 Reflex Syncope Reflex (vasovagal) (neurocardiogenic) syncope (also known as the “common faint”) refers to a variety of clinical scenarios in which a neural reflex results in usually self- limited systemic hypotension characterized by bradycardia and/or peripheral vasodilation. It is the most common cause of syncope (approximately 20 to 35 percent of cases), particularly in patients without apparent cardiac or neurologic disease. However, reflex syncope is the most common cause of syncope even among patients with heart disease and should be considered as a potential cause in such patients.

97 Reflex Syncope It is a common cause of syncope in athletes. However, other potential causes of syncope should be considered and evaluated before identifying the etiology of syncope, particularly if the syncope occurs during exertion. Athletes with syncope during physical activity should be evaluated for potential risk of sudden death.

98 History Reflex Syncope Clinical presentation — Patients with vasovagal syncope are most commonly young and otherwise healthy. Typical triggers and premonitory symptoms are strongly suggestive of vasovagal syncope, although these may be absent or difficult to correlate to the syncopal episode. Women and patients younger than 40 are more likely to have typical symptoms. However, older patients are also frequently diagnosed with vasovagal syncope. Older individuals have specific triggers that may be absent in younger individuals (i.e., micturition, cough, defecation, deglutition).

99 Tilt Table Testing The tilt table test has limited specificity, sensitivity, and reproducibility.

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101 Treatment Reflex Syncope No therapy has been proven effective for recurrent vasovagal syncope. Some intuitively appealing therapies have not proven effective. Therapy is particularly important in patients who have recurrent syncope in high-risk settings (e.g., commercial vehicle driver, pilot) and who wish to continue these activities. Patients with recurrent episodes may require restriction of activities until therapy is shown to be effective.

102 Treatment Reflex Syncope Explanation — Patients with vasovagal syncope should be provided with reassurance and education regarding the nature, risks, and prognosis of the condition. The patient should be advised to assume the supine position with legs raised at the onset of symptoms. The patient should be advised to avoid trigger events when feasible, and medications that may induce hypotension should be modified or discontinued. A study of self-reported symptom burden in 418 patients diagnosed with vasovagal syncope indicated that 35 percent were symptom free at median five-year follow-up, regardless of presenting symptom or treatment received.

103 Treatment Reflex Syncope Physical counterpressure — Studies have found that isometric activity, such as crossing the legs and the arms, may be helpful to offset a syncopal response, but release of this position may be associated with precipitous decline in heart rate and blood pressure. Counter-pressure maneuvers, such as tensing the arms with clenched fists, leg pumping, and leg-crossing may abort a syncopal episode or at least delay it long enough that patients can assume the supine position. Physical counterpressure maneuvers are intended to reduce lower-extremity venous pooling and therefore improve cardiac output and prevent vasovagal syncope.

104 Treatment Reflex Syncope Maneuvers include: ■ Leg-crossing with simultaneous tensing of leg, abdominal, and buttock muscles. ■ Handgrip, which consists of maximum grip on a rubber ball or similar object. ■ Arm tensing, which involves gripping one hand with the other while simultaneously abducting both arms

105 Treatment Reflex Syncope Evidence from clinical trials suggests a limited role for pacemaker therapy in patients with vasovagal syncope.

106 Treatment Reflex Syncope Some have recommended support stockings (in some cases, Jobst stockings), volume expansion by liberalizing salt intake, and occasionally administration of the mineralocorticoid fludrocortisone (similar to the regimen used in the treatment of orthostatic hypotension). Data are lacking to support this approach in treating reflex syncope.

107 Treatment Reflex Syncope Some patients with vasovagal syncope respond poorly to general measures. Orthostatic or tilt training may be an effective approach, although study results have been mixed.

108 Treatment Reflex Syncope The efficacy of orthostatic training started in hospital and continued at home was suggested by a controlled but non-randomized study. Forty-seven patients with recurrent syncope and a positive upright tilt table test who were refractory to traditional therapies were assigned to a tilt-training program or to continued medical therapy, depending upon their consent. The training program included five daily in-hospital upright tilt table studies increasing in duration from 10 to 50 minutes. The training program was continued at home with the patient instructed to stand against a wall for up to 40 minutes twice a day, under supervision of a family member.

109 Treatment Reflex Syncope Wall stands with progressive increase in time over 6 to 8 weeks can improve symptoms, possibly by retraining baroreceptor reflexes. While the individual is standing, the upper back is positioned against a wall without arm and leg movement, beginning with 5-minute intervals twice daily and increasing gradually to 30-minute to 40-minute intervals over 6 to 8 weeks.

110 Treatment Reflex Syncope Moderate exercise training — Limited uncontrolled data suggest that moderate exercise training may increase orthostatic tolerance in patients with syncope.

111 Driving Restrictions According to your State Laws

112 References Vanderbilt Autonomic Dysfunction site (www.mc.vanderbilt.edu/gcec/adc)www.mc.vanderbilt.edu/gcec/adc DOI: /peds Pediatrics 2013;131;968; originally published online April 8, 2013; Julian M. Stewart Common Syndromes of Orthostatic Intolerance Postural Tachycardia Syndrome: A Heterogeneous and Multifactorial Disorder Eduardo E. Benarroch, MD, DScMayo Clin Proc. 2012;87(12):

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