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Analysis of lytic proteins pinholin and Rz/Rz1 Sue Parks and Lawangin Khan.

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Presentation on theme: "Analysis of lytic proteins pinholin and Rz/Rz1 Sue Parks and Lawangin Khan."— Presentation transcript:

1 Analysis of lytic proteins pinholin and Rz/Rz1 Sue Parks and Lawangin Khan

2 2 SRRz Rz1 Lytic Cassette

3 3 Comparative analysis of Trans-Membrane domain Motifs in pinholin proteins

4 Two Domains in the Pinholin Protein Pang et al.(2010) Mutational Analysis of S21 pinholin. Molecular Biology, 76(1): 66-77. Figure 1D: Phage S21 reading frame

5 Traditional Holin Model TM1 TM2 TM3

6 TMD2TMD1 Text

7 Motifs TMD1TMD2MXXM

8 Comparative analysis of lysis protein, Rz1 cleavage sites Lawangin Khan

9 Localization? Why Cleave? Cleave site

10 Cleavage site conserved? Determining cleavage site Determined by LipoP, (www.cbs.dtu.dk/services/LipoP/)www.cbs.dtu.dk/services/LipoP/

11 Comparative Analysis

12 Relative Consensus and Position Krupovic’s lipobox consensus: L(A/S)(G/A)C


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