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Jyrki Törnvall, Mesimäki, Risto Kontio Jaw bone defect – Soft tissue defect.

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Presentation on theme: "Jyrki Törnvall, Mesimäki, Risto Kontio Jaw bone defect – Soft tissue defect."— Presentation transcript:

1 Jyrki Törnvall, Mesimäki, Risto Kontio Jaw bone defect – Soft tissue defect

2 Preop

3 May 07 ASCs, ß TCP,BMP 2

4 Suomen Kuvalehti In the OR In the Lab 2) Fat is broken to 1-cell suspension and stem cells extracted 3) Stem cells and expanded to abt 1 million 4) Cells are combined with biomaterial and GF is added 5) The combination is placed in a titanium cage 1) 1dl fat containing 100 000 stem cells 6) The construct is placed in a prepared muscle pouch 7) The TRAM-flap combination is raised and transplanted to the defect site. It is rigidly fixed with titanium screws. From FAT to bone in few months

5 October 07

6

7 December 07

8 March 08

9 October 08

10 1) Harvest adipose tissue 3) Combine cells with growth factor BMP-2 and biomaterial * * * * ** * = growth factor * = biomaterial 2) Isolate and culture adipose stem cells (10 days ) 4) The mix is placed directly into the patients defect site = adipose tissue Ameloblastoma treatment using adipose stem cells and biomaterials


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