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The Well- Connected Cell Text and image sources are included using the notes function of this file
Classes of cell-cell junctions typefunction tight junctionssealing anchoring junctionsstructural interconnection communicating junctions communication
Tight (Occluding) Junctions ZO-1 ZO-3 DNA Claudins Occludins JAMs Organizers Informants Sealers ß-catenin PTEN
Tight Junctions seal dense tracer
Tight Junction interactome
Anchoring junctions strengthen
I. Belt (Adherens) Junctions in cardiac muscle Cadherin CAMs
Belt Junctions back up tight junctions
The Adherens Junction Interactome The Adherens Junction interactome
Forging links GFP::actin
II. Desmosomal Junctions Cytokeratin Desmosomes (Plakoglobins anchor MFs)
A day in the life of an epithelium Desmocollin -GFP Imaged over a 24 hour period
III. Hemidesmosomes anchor IMF to ECM via integrin Heterodimers (18 alpha x 8 beta) ECM RGD (Arg-Gly-Asp)
Loss of hemidesmosomal connections creates blistering diseases
IV. Focal Adhesion sites (FAds) link microfilaments to ECM
Focal Adhesion Kinase (FAK) /VASp
FAds anchor stress fibers Actin-GFP and Vinculin
GFP::VASp localizes at FAds
Special Delivery? Microtubules target FAds GFP::tubulin and Ds-Red::zyxin FAds) GFP::CLIP-170 (+TIP) and Ds-Red::zyxin FAds)
Communicating Junctions GFP-Connexin-43 localizes at cell-cell contact points
Connexin hexamers form gap junctions fields 2nm
Gap junction fields Tightly- packed gap junctions
Gap junctions permit low MW molecules (<1kDa) to move between cells scrape
Gap junction interactome
AFM of gap junction field reveals the 6- fold symmetry of the connexion channel +Ca ++ -Ca ++ And a role for calcium in conductance regulation
Electrical coupling in engineered heart muscle tissue
Plasmodesmata The symplast refers to the linked protoplasmic network in plants
Plant cell lineages are linked in distinct symplastic routes
MULTICELLULAR ORGANISMS Cell-Cell Adhesion Cell-Matrix Adhesion The Extracellular Matrix, ECM M. Habibi-Rezaei.
THE CELL. YOU MUST KNOW… THE DIFFERENCES BETWEEN PROKARYOTIC AND EUKARYOTIC CELLS THE STRUCTURE AND FUNCTION OF ORGANELLES COMMON TO PLANT AND ANIMAL.
Chapter 6 A Tour of the Cell. You should be able to: 1.Distinguish between the following pairs of terms: magnification and resolution; prokaryotic and.
CELLS. Cells basic structural & functional units of all living organisms.
Copyright © 2005 Pearson Education, Inc. publishing as Benjamin Cummings PowerPoint Lectures for Biology, Seventh Edition Neil Campbell and Jane Reece.
The cell and its environment. The cell within the organism.
The Cell The Basic Unit of Life. The Importance of Cells All organisms are made of cells The cell is the simplest collection of matter that can live.
Biological Membranes. Biological membranes Biological membranes Complex, dynamic structures made of lipid and protein molecules Complex, dynamic structures.
The cell The cell is the smallest unit of life Science and technology evolve together microscope Cell theory All living things are made up of 1 or more.
TISSUE LEVEL OF ORGANIZATION. 4 BASIC TISSUE TYPES Epithelial Connective Muscle Nervous.
Unit II: The Cell All organisms are made of cells, the organisms basic unit of structure and function.
Dvt 1102 hISTOLOGY Tissues - collections of similar cells and the substances surrounding them Tissue classification based on structure of cells, composition.
Cell Communication Cells need to communicate with one another, whether they are located close to each other or far apart. Extracellular signaling molecules.
Chapter 15 Neurogenesis and Migration Copyright © 2014 Elsevier Inc. All rights reserved.
AP Biology Chapter 11 Cell Communication AP Biology Gap junctions between animal cells Cell-Cell Communication Animal cells use gap junctions to send.
1 Chapter 9 Cell Adhesion Molecules Copyright © 2012, American Society for Neurochemistry. Published by Elsevier Inc. All rights reserved.
The Cellular Internet Cell-to-cell communication is essential for multicellular organisms Biologists have discovered some universal mechanisms of cellular.
Chapter 5 continued Section 5.3: Plasma Membrane Permeability Section 5.4: Modification of Cell Surfaces.
Ch. 8 Cell Structure & Function Lesson 2 How are Cells Specialized?
Copyright © 2004 Pearson Education, Inc. publishing as Benjamin Cummings PowerPoint ® Lecture Slides for Essential Biology, Second Edition & Essential.
Johnson - The Living World: 3rd Ed. - All Rights Reserved - McGraw Hill Companies The Animal Body and How It Moves Chapter 22 Copyright © McGraw-Hill Companies.
Cell Structure and Function Chapter What is a Cell? Each cell has a plasma membrane, cytoplasm, and a nucleus (in eukaryotic cells) or a nucleoid.
Ch 6 and 7 review. Endosymbiosis theory Organelles and their sizes What is a centrifuge? What cell parts will fall to the bottom first? Heavy or light?
Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings PowerPoint ® Lecture Presentations for Biology Eighth Edition Neil Campbell.
The Main Body Parts In The Muscular System There are three types of main body parts in the muscular system, the three main body parts in the muscular.
Cell Structure and Function Chapter 6. Mid 1600s - Robert Hooke observed and described cells in cork Late 1600s - Antony van Leeuwenhoek observed sperm,
1 Chapter 4 The Tissue Level of Organization Group of similar cells common embryonic origin common function Histology study of tissues Pathologist looks.
Copyright 2007 by Saunders/Elsevier. All rights reserved. Chapter 9: Nervous Tissue Color Textbook of Histology, 3rd ed. Gartner & Hiatt Copyright 2007.
Chapter 5.2 Overview of the Membrane Proteins AP Biology Fall 2010.
Chapter 11 Muscle Tissue Types and Characteristics of Muscular Tissue The Nerve-Muscle Relationship Behavior of Skeletal Muscle Fibers Behavior of Whole.
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