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The Well- Connected Cell Text and image sources are included using the notes function of this file
Classes of cell-cell junctions typefunction tight junctionssealing anchoring junctionsstructural interconnection communicating junctions communication
Tight (Occluding) Junctions ZO-1 ZO-3 DNA Claudins Occludins JAMs Organizers Informants Sealers ß-catenin PTEN
Tight Junctions seal dense tracer
Tight Junction interactome
Anchoring junctions strengthen
I. Belt (Adherens) Junctions in cardiac muscle Cadherin CAMs
Belt Junctions back up tight junctions
The Adherens Junction Interactome The Adherens Junction interactome
Forging links GFP::actin
II. Desmosomal Junctions Cytokeratin Desmosomes (Plakoglobins anchor MFs)
A day in the life of an epithelium Desmocollin -GFP Imaged over a 24 hour period
III. Hemidesmosomes anchor IMF to ECM via integrin Heterodimers (18 alpha x 8 beta) ECM RGD (Arg-Gly-Asp)
Loss of hemidesmosomal connections creates blistering diseases
IV. Focal Adhesion sites (FAds) link microfilaments to ECM
Focal Adhesion Kinase (FAK) /VASp
FAds anchor stress fibers Actin-GFP and Vinculin
GFP::VASp localizes at FAds
Special Delivery? Microtubules target FAds GFP::tubulin and Ds-Red::zyxin FAds) GFP::CLIP-170 (+TIP) and Ds-Red::zyxin FAds)
Communicating Junctions GFP-Connexin-43 localizes at cell-cell contact points
Connexin hexamers form gap junctions fields 2nm
Gap junction fields Tightly- packed gap junctions
Gap junctions permit low MW molecules (<1kDa) to move between cells scrape
Gap junction interactome
AFM of gap junction field reveals the 6- fold symmetry of the connexion channel +Ca ++ -Ca ++ And a role for calcium in conductance regulation
Electrical coupling in engineered heart muscle tissue
Plasmodesmata The symplast refers to the linked protoplasmic network in plants
Plant cell lineages are linked in distinct symplastic routes
CELL TO CELL JUNCTIONS BY: ASHLEY COHN. SURFACE MARKERS STRUCTURE VARIABLE, INTEGRAL OR GLYCOLIPIDS IN PLASMA MEMBRANE. FUNCTION IDENTIFY THE CELL EXAMPLE.
Chapter 18 Cell Junctions, Cell Adhesion, and the Extracellular Matrix.
CELL-TO-CELL JUNCTIONS Michaela Tiffany. SURFACE MARKERS Structure: Variable, integral proteins or glycolipids in plasma membrane Function: Identify the.
Last Class 1. ECM components: glycosaminoglycans (GAGs) and fibrous proteins a. GAGs: Hyaluronan; Chondroitin sulfate and dermatan sulfate; Heparan sulfate;
Cancer II. Six ways of losing the remaining good copy of a tumor suppressor gene.
The Extracellular Space Epithelial tissues –closely packed cells lining spaces in the body (e.g. skin, intestine, etc) Connective tissues –Largely composed.
MB 207 Molecular cell biology Cell junctions, cell adhesion and the extracellular matrix.
Dr Mahmood S Choudhery, PhD Assistant Professor Advance Center of Research in Biomedical Sciences Incharge Tissue Engineering Laboratory, Mayo Hospital.
Interaction of Cells with Other Cells (5) Cadherins – glycoproteins that mediate Ca 2+ - dependent cell-cell adhesion.
CELL STRUCTURE & FUNCTION Dr. Michael C. Potter Paul VI Catholic High School 2006.
Extracellular Structures, Cell Adhesion & Cell Junctions.
Fig Simplified drawing of a cross-section through part of the wall of the intestine. Each tissue is an organized assembly of cells held together.
Cell-cell adhesion occurs through morphological structures and CAMs.
Three Types of Junctions Occluding junctions – Zonula occludens Occluding junctions – Zonula occludens restrict and direct movement of fluids in intercellular.
Extracellular Matrix. Readings and Objectives Reading Reading – Cooper: Chapter 14 Topics Topics The Extracellular Matrix Composition Cell-Matrix Interactions.
Epithelial Cell Domains Charles L. Hitchcock, MD, PhD Department of Pathology.
How do coated vesicles go to the right place and fuse with the right membrane? The “SNARE” hypothesis.
Day 38 Announcements Friday, April 13: Junctions, the nucleus: pp , –Homework problems 15-3, 17-9 due Monday, April 16: the cell cycle,
Tight Junctions Occluding junctions Sealing strands are rows of transmembrane proteins.
Tissues & Junctions Lecture 34 Chapter 21 - Part 1.
Cell Junctions and extra cellular matrix II chapter 19.
Cell Junctions, Cell Adhesion, and the Extracellular Matrix.
Why to communicate/ cordinate 1……. 2……. 3…………. Communication levels Cellular level Tissue Organ level Environment Need for communication.
Raven - Johnson - Biology: 6th Ed. - All Rights Reserved - McGraw Hill Companies Cell-Cell Interactions Chapter 7 Copyright © McGraw-Hill Companies Permission.
Chapter 6 Section 6.7. Vocabulary You Need To Know Cell wall Primary Cell Wall Middle Lamella Secondary Cell Wall ECM(Extracellular matrix) Collagen Proteoglycans.
Cell Junctions anchoring. Types of Cell Junctions In plants: –Plasmodesmata In animals: ECM (Extra-cellular Matrix)- –Tight Junctions –Anchoring Junctions.
Cell Signaling. Apoptosis, which can be induced by signals from other cells, is the process by which cells do which of the following? A) Move to other.
Chapter 3b Compartmentation: Cells and Tissues. Golgi Complex Membranes surrounded by vesicles Protein modification Protein packaging into secretory vesicles.
Cell Connections & Junctions by Dr. Vani Gupta. Definition and Classification of cell junction Cell junction is the connection between the neighbouring.
CHAPTER 3 A TOUR OF THE CELL Cell Surfaces and Junctions 1.Plant cells are encased by cell walls 2. The extracellular matrix (ECM) of animal cells functions.
CELL JUNCTION. CELL JUNCTIONS In certain tissues the membranes of adjacent cells may join and form a junction called a cell junction. These are specialized.
Finish Cancer Lecture Tissues and Cell-Cell Interactions.
Cell and Molecular Biology Fifth Edition CHAPTER 7 Part 2 Interactions Between Cells and Their Environment Copyright © 2008 by John Wiley & Sons, Inc.
Tissues Chapter 13. Differential Cell Affinities Cells alter cell surface during development to change affinities. This allows different interactions.
CHAPTER 7 A TOUR OF THE CELL Copyright © 2002 Pearson Education, Inc., publishing as Benjamin Cummings Section G: Cell Surfaces and Junctions 1.Plant cells.
Chapter 19: Cell junctions and the extracellular matrix Know the terminology: Cadherins, integrins, tight junction, desmosome, adhesion belt, hemidesmosome,
Lecture 10: Cell Biology interactive media ”video” or ”animation ” The eukaryotic kingdom 1 Cell biology 2014 (revised 12/2-13)
Ch. 4 Part 1 Tissues and Junctions. Histology Science that deals with the study of tissues Tissue – group of similar cells that usually have a common.
Cell Adhesion and Extracellular Matrix. Cells in tissues can adhere directly to one another (cell–cell adhesion) through specialized integral membrane.
CELL SIGNALING. THREE LEVELS OF CONTACT WITH ENVIRONMENT.
Cell and Molecular Biology Fifth Edition CHAPTER 7 Part 3 Interactions Between Cells and Their Environment Copyright © 2008 by John Wiley & Sons, Inc.
Fundamentals of Cell Biology Chapter 6: The Extracellular Matrix and Cell Junctions.
Boundless Lecture Slides Free to share, print, make copies and changes. Get yours at Available on the Boundless Teaching Platform.
Cell Junctions structure & role presented by Suman.Thota M.Pharm I I-Semester Department of Industrial Pharmacy UNIVERSITY COLLEGE OF PHARMACEUTICAL SCIENCES.
Chapter 4. 4 major types of tissues Epithelial tissue- Covers surface of body, lines hollow organs and body cavities. Ex: Skin and stomach tissue Connective.
Biology 107 Cellular Communication October 7, 2002.
Cellular Adhesion and Tissue Ahmed A. Mirza, PhD, MT(ASCP)
Tissues are: Tissues are: Collections of specialized cells and cell products organized to perform a limited number of functions Collections of specialized.
Human Physiology: Cell structure and function and Organization of cells, tissues and organs, systems Source: Collected from different sources on the internet-http://koning.ecsu.ctstateu.edu/cell/cell.html.
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