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Computational Biology Lecture Slides Week 10 Classification (some parts taken from Introduction to Data Mining by Tan, Steinbach, Kumar)

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MBG404 Overview Data Generation Processing Storage Mining Pipelining

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Data Mining Data mining –noun Digital Technology. The process of collecting, searching through, and analyzing a large amount of data in a database, as to discover patterns or relationships: e.g.: the use of data mining to detect fraud. Machine learning a branch of artificial intelligence, concerning the construction and study of systems that can learn from data. For example, a machine learning system could be trained on email messages to learn to distinguish between spam and non-spam messages. After learning, it can then be used to classify new email messages into spam and non-spam folders.

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Application in Biology Data exploration –Microarrays –Next generation sequencing Prediction –microRNAs –Protein secondary structure

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Parametrization

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Types of Attributes There are different types of attributes –Nominal Examples: ID numbers, eye color, zip codes –Ordinal Examples: rankings (e.g., taste of potato chips on a scale from 1- 10), grades, height in {tall, medium, short} –Interval Examples: calendar dates, temperatures in Celsius or Fahrenheit. –Ratio Examples: temperature in Kelvin, length, time, counts

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Data Type Distinctness (nominal) –Equal or unequal Order (ordinal) –>, =,<= Addition (interval) –+,- Multiplication (ratio) –*,/

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Data Quality Missing data Noise False measurements Outliers Duplicate data Precision Bias Accuracy

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Data Preprocessing Aggregation Sampling Dimensionality Reduction Feature subset selection Feature creation Discretization and Binarization Attribute Transformation

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Aggregation Standard Deviation of Average Monthly Precipitation Standard Deviation of Average Yearly Precipitation Variation of Precipitation in Australia

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Dimensionality Reduction: PCA

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Similarity/Dissimilarity for Simple Attributes p and q are the attribute values for two data objects.

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Similarity Eucledian distance Simple matching coefficient –Jaccard coefficient Correlation Cosine similarity...

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Sampling Curse of dimensionality –Feature selection –Dimensionality reduction –Principal component analysis –Aggregation –Mapping of data to different space

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Sampling Dividing samples into –Training set –Test set Using not all samples from both sets

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Classification Examples with known classes (labels) Learn rules of how the attributes define the classes Classify unknown samples into the appropriate class

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Classification Workflow

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End Theory I 5 min Mindmapping 10 min Break

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Practice I

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Exploring Data (Irises) Download the file Iris.txt Follow along

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Exploring Data Frequencies Percentiles Mean, Median Visualizations

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Data Selection Selecting columns Filtering rows

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Data Transformation Discretize Continuize Feature construction

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Visualizations

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End Practice I Break 15 min

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Theory II

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Classification Workflow

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Illustrating Classification Task

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Example of a Decision Tree categorical continuous class Refund MarSt TaxInc YES NO YesNo Married Single, Divorced < 80K> 80K Splitting Attributes Training Data Model: Decision Tree

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General Structure of Hunt’s Algorithm Let D t be the set of training records that reach a node t General Procedure: –If D t contains records that belong the same class y t, then t is a leaf node labeled as y t –If D t is an empty set, then t is a leaf node labeled by the default class, y d –If D t contains records that belong to more than one class, use an attribute test to split the data into smaller subsets. Recursively apply the procedure to each subset. DtDt ?

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Hunt’s Algorithm Don’t Cheat Refund Don’t Cheat Don’t Cheat YesNo Refund Don’t Cheat YesNo Marital Status Don’t Cheat Single, Divorced Married Taxable Income Don’t Cheat < 80K>= 80K Refund Don’t Cheat YesNo Marital Status Don’t Cheat Single, Divorced Married

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How to Find the Best Split B? YesNo Node N3Node N4 A? YesNo Node N1Node N2 Before Splitting: M0 M1 M2M3M4 M12 M34 Gain = M0 – M12 vs M0 – M34

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Underfitting and Overfitting Overfitting Underfitting: when model is too simple, both training and test errors are large

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Overfitting due to Noise Decision boundary is distorted by noise point

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Overfitting due to Insufficient Examples Lack of data points in the lower half of the diagram makes it difficult to predict correctly the class labels of that region - Insufficient number of training records in the region causes the decision tree to predict the test examples using other training records that are irrelevant to the classification task

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Cost Matrix PREDICTED CLASS ACTUAL CLASS C(i|j) Class=YesClass=No Class=YesC(Yes|Yes)C(No|Yes) Class=NoC(Yes|No)C(No|No) C(i|j): Cost of misclassifying class j example as class i

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Cost-Sensitive Measures l Precision is biased towards C(Yes|Yes) & C(Yes|No) l Recall is biased towards C(Yes|Yes) & C(No|Yes) l F-measure is biased towards all except C(No|No)

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Receiver Operating Characteristic (ROC) Curve (TP,FP): (0,0): declare everything to be negative class (1,1): declare everything to be positive class (1,0): ideal Diagonal line: –Random guessing –Below diagonal line: prediction is opposite of the true class

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Using ROC for Model Comparison l No model consistently outperform the other l M 1 is better for small FPR l M 2 is better for large FPR l Area Under the ROC curve l Ideal: Area = 1 l Random guess: Area = 0.5

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End Theory II 5 min Mindmapping 10 min Break

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Practice II

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Learning Supervised (Classification) –Classification Decision tree SVM

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Classification Use the iris.txt file for classification Follow along as we classify

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Classification Use the orangeexample file for classification We are interested if we can distinguish between miRNAs and random sequences with the selected features Try yourself

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