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HAART Highly Active Antiretroviral Therapy Randi Puffenberger Shey Veditz George Parish Amy Keister Matt Lake.

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Presentation on theme: "HAART Highly Active Antiretroviral Therapy Randi Puffenberger Shey Veditz George Parish Amy Keister Matt Lake."— Presentation transcript:

1 HAART Highly Active Antiretroviral Therapy Randi Puffenberger Shey Veditz George Parish Amy Keister Matt Lake

2 What is HAART?  Triple Therapy –Two nucleoside analogs –One protease inhibitor  Multi drug regimens useful because many times one drug fails to block viral replication

3 Drawbacks of HAART  Requires at least 8-24 pills a day, with specific dose requirements for each  Can cost $10,000 -$12,000 per year  Memory t-cells all but disappear causing immune system to ‘forget’ how to handle the virus  Side effects include: rash, nausea, diarrhea, anemia, neuropathy, hepatitis, diabetes, and headache

4 Treatment Strategy  Most appropriate for: –People in acute stage of disease Rare that disease is caught at this stage –People who already have symptoms or low CD4 t-cell count –Symptom less patients with relatively low CD4 t-cell count

5 How HAART Treatment Works  Prevents enzyme function by binding to active site of protease enzyme  Prevents virus replication  Use multiple drugs to counter mutations that cause drug resistance

6 Conclusion  Patients using HAART do not develop resistance and with hope can continue on it indefinitely  Clinical studies show HAART to be the most effective treatment method for maximum viral suppression


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