Presentation on theme: "Common cutaneous bacterial infections"— Presentation transcript:
1Common cutaneous bacterial infections Faghihi. G.Dermatology professorIsfahan University of Med.
2Normal skin is a barrier against microbial pathogens
3Predisposing factors to Bacterial Skin Infections : NeutropeniaHIV infectionIV Drug ABUSEDiabetesParasitic InfestationsWounds,burns,abrasionsAtopic diseaseAlcoholismMRSA Abscess and Surrounding Cellulitis in Arm of Patient with HIV Infection
4Some other conditions as risk factors for bacterial cut. Infections For example :poor hygienefriction and wearing tight clothingseborrhea
5Common important bacterial skin infections Include:Impetigofolliculitisfurunclescarbunclescellulitiserysipelas
6Impetigo pustules or bullae that rupture and become crusted usually appears on the face, especially around nose and mouth mainly affects infants and children
7The infection is spread by direct contact with lesions or with nasal carriers. The incubation period is 1–3 days after exposure to Streptococcus and 4–10 days for Staphylococcus
8The most common pathogen Both bullous and nonbullous are primarily caused by Staphylococcus aureus with Streptococcus also commonly being involved in the nonbullous form.
9Risk factors for Impetigo Atopic dermatitisparasitosisTraumaBurnsminor abrasionsSports(direct contact)
10Diagnosis usually clinically smear and culture definitely Leucocytosis … About 50 % patients
11Children who get impetigo: should not attend school or daycare. They should not have close contact, with other children
12limited uncomplicated impetigo Treatment(topical): Ointment mupirocinOintment retapamulinCream fusidic acidEqually as effective as oral Ab.
13Extensive or accompanied systemic symptoms or lymphangitis(systemic Ab Penicillins( dicloxacillin, flucloxacillin or Alternatively amoxicillin combined with clavulanateCephalosporinsClindamycinMacrolidsIn cases of severely ill/ immunocompromisedIV ceftriaxoneIv ampicillin/sulbactam/cefuroxime
14One major complication of impetigo: Post Strep GN
15Efficacy of treatment of strep.impetigo is not known.In eradication acute P-S-G-N
19a superifical staphyloccocal folliculitis with thin-walled pustules at the folliclular openings.
20Streptococcal intertrigo is a cutaneous condition seen in infants and young children, characterized by a fiery-red erythema and maceration in the neck, axillae or inguinal folds a distinctive foul odor and an absence of satellite lesions.
21Treatment strep.intertrigo eliminate friction, heat, and maceration by keeping folds cool and dryCompresses with Burow solution 1:40Treatment with penicillin V-K suspension, 125 mg orally 3 times a day 10 days
23The bacterial agent often responsible for folliculitis is Staphylococcus aureus The infection (hair follicles)can be shallow or deep can even lead to formation of inflammatory nodules or pustules which will surround the hair follicle.
24superficial folliculitis (the most common form) Deep folliculitis (sycosis)Folliculitis most commonly occurs://Beard area in menScalpUpper trunk (chest, under breasts, in armpits)ButtocksThighsGroin
25Pseudomonas aeruginosa folliculitis hot tub folliculitisThe infection is typically found in areas of the body, which are soaked under an improperly chlorinated hot tub or wirlpools.The typical body parts affected ::are buttocks, hips, legs and thighs ,face and neck are spared.It is self limited(7-14 Days)Sometimes for widespread infection or immunosuppressed or febrile ,ill patients:oral quinolone/topical gentamycin
26Folliculitis Treatment Superficial folliculitis may heal on its own within 1 to 2 weeksApplying antibiotic ointments like Bacitracin, (bacitracin + neomycin + polymyxin B), or (mupirocin), washing with antibacterial soaps may help in more resistant casesIn a deep folliculitis and recurrent cases, oral antibiotics (dicloxacillin, cephalosporins) may be needed.Folliculitis caused by MRSA requires treatment by antibiotics chosen on the basis of antibiotic sensitivity test (1).S. aureus carriers may be treated with mupirocin ointment in the nasal vestibule as previously said...Family members may be also treated by mupirocin to eliminate the carrier state and prevent re-infection
27(boil ) furuncleFuruncles are skin abscesses caused by staphylococcal infection, which involve a hair follicle and surrounding tissue.
28A carbuncleis a coalescence of several inflamed follicles into a single inflammatory mass with purulent drainage from multiple follicles. Constitutional symptoms, including fever and malaise, are commonly associated with these lesions but are rarely found with furuncles.
29Diff Dx furuncles or carbuncles Ruptured epidermal cysts or pilar cystsAcne conglobataHidradenitis suppur.
30Patients with recurrent furunculosis should be evaluated:predisposing factors such asobesity,diabetes,occupational or industrial exposure to inciting factors,nasal carriage of Staphylococcus aureus or ,/methicillin-resistant S. aureus (MRSA) colonization.
31Furuncles treat./Treatment with warm compresses antiseptic sol./ or incision and drainageSystemic antibiotics:(multiple furuncles,severe illness, systemic signs, immunosuppresed , cellulitis around lesions , Areas like nose, Ear canal ,face and genitalia and acral parts:Cloxacillin,dicloxacillin,CA-MRSA: (Cotrimoxazole , doxy, clinda )
33Cellulitis is a deep infection of the skin, (dermis/ subcutis) usually accompanied by generalized (systemic) symptoms such as fever and chills.
34streptococci , Staphylococcus and H streptococci , Staphylococcus and H.influenza, are the most common causes of cellulitis.
35Cellulitis causes the affected area of skin to turn red, painful, hot and swollen
36Risk factors for cellulitis a skin condition such as eczema or a fungal infection of the foot or toenails (athlete’s foot) can cause small breaks to develop in the surface of the skin.having a weakened immune system (as a result of health conditions such as HIV or diabetes, or as a side effect of a treatment such as chemotherapylymphoedema – a condition that causes swelling of the arms and legs, which can sometimes occur spontaneously or may develop after surgery for some types of cancerVenous insufficiencyintravenous drug abuse (injecting drugs such as heroin)
38Venous Insufficiency With Supra-Imposed Ulceration and Severe Cellulitis
39In healthy adultsisolation of an etiologic agent is difficult and unnecessary. If the patient has: diabetes, an immunocompromising disease, or persistent inflammation: blood cultures or aspiration of the area of maximal inflammation may be useful.
40Indications for IV antibiotics in cellulitis Severely ill patientsthose whose condition is unresponsive to standard oral antibiotic therapyImmunosuppressed patientsPatients with facial cellulitisAny patient with a clinically significant concurrent condition, including lymphedema and cardiac, hepatic, or renal failureIndividuals with newly elevated creatinine, creatine phosphokinase, and/or low serum bicarbonate levels or marked left-shift polymorphonuclear neutrophils
41In cases of cellulitis without draining wounds or abscess, streptococci continue to be the likely etiology,and beta-lactam antibiotics are appropriate therapy, as noted in the following:In mild cases of cellulitis treated on an outpatient basis, dicloxacillin, amoxicillin, and cephalexin are all reasonable choicesClindamycin or a macrolide (clarithromycin or azithromycin) are reasonable alternatives in patients who are allergic to penicillinfluoroquinolones are best reserved for gram-negative organisms with sensitivity demonstrated by cultureSome clinicians prefer an initial dose of parenteral antibiotic with a long half-life (eg, ceftriaxone followed by an oral agent)
43Antibiotics should be maintained for at least three days after the resolution of acute inflammation Adjunctive therapy includes:cool compresses;appropriate analgesics for pain;tetanus immunization; andimmobilization and elevation of the affected extremity
44more severe cases that require parenteral antibiotics to cover MRSA , vancomycin,daptomycin,tigecycline,ceftaroline, andlinezolid are appropriate choices.However, vancomycin continues to be the drug of choice because of its overall excellent tolerability profile, efficacy, and cost
46an acute streptococcus bacterial infection of the upper dermis and superficial lymphatics.
47Historically, the face was most affected; today the legs are affected most often The erythematous skin lesion enlarges rapidly and has a sharply demarcated raised edge.
48It appears as a red, swollen, warm, hardened and painful rash, similar in consistency to an orange peel. More severe infections can result in vesicles, bullae, and petechiae, with possible skin necrosis.
49Blood cultures are unreliable for diagnosis of the disease, but may be used to test for sepsis. Elevation of (ASO) titer occurs after around 10 days of illness. Erysipelas must be differentiated from: herpes zoster, angioedema, contact dermatitis, and diffuse inflammatory carcinoma of the breast.
51Acute cut,. infection with Erysipelothrix rhusiopathiae Acute cut,. infection with Erysipelothrix rhusiopathiae. This type of bacteria is found in fish, birds, mammals, and shellfish. It usually affects people who work with these animals (such asfishermen , farmers or butchers).
52Symptoms warmth, tenderness, and redness (non purulant cellulitis)on the skin Treatment Antibiotics, especially penicillin, are used to treat alternatives: erythromycin cephalosporine tetracyclines The infection rarely spreads. It may be self limited.
55The patches of erythrasma are initially pink, but progress quickly to become brown and scaly (as skin starts to shed), which are classically sharply demarcated. Erythrasmic patches are typically found in intertriginous areas (skin fold areas - e.g. armpit, groin, under breast) - with the toe web-spaces being most commonly involved. The patient is commonly otherwise asymptomatic. The diagnosis can be made on the clinical picture alone. It is prevalent among diabetics and the obese, and in warm climates; it is worsened by wearing occlusive clothes.