glycoprotein: LCMV-GPglycoprotein:IND-G rLCMV/INDGrVSV/LCMV-GP reverse genetic glycoprotein exchange between LCMV and VSV LCMVVSV-IND glycoprotein: LCMV-GPglycoprotein:IND-G
Only VSVG expressing viruses induce a neutralizing antibody response
Immunological memory Quicker (earlier) Greater (better) responses Immunity Protection against disease by reinfection First infection kills host: No memory needed Host survives first infection: Memory not needed neither
No protection by Memory B cells but protection by immune serum in IFN-aBR _ / _ against VSV VSV IND immune spleen cells T+B LCMV immune spleen cells VSV IND Ab Anti-VSV neutr. AB < 1 : 40 < 1 : 2500 % Survivors 0 100
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