Presentation on theme: "An Overview of the Research Institute 2015"— Presentation transcript:
1 An Overview of the Research Institute 2015 Prof Alicia El HajDirector, Institute for Science & Technology in Medicine, Keele University
2 www.keele.ac.uk Keele University A campus-based university located in the West Midlands of England, offering dual-honours degrees and research in science, social science and humanities.Founded as a University College in 1949, it received its Royal Charter in 1962.
3 Research Institute for Science & Technology in Medicine (ISTM) A multidisciplinary Institute formed in 2006 to underpin the new Medical School established between Keele and Manchester UniversitiesKeele Medical SchoolISTM brings together dispersed clinical and laboratory-based researchers from different departments and cultures.School of Life SciencesUniversity Hospital of North Staffordshire(PFI development)Guy Hilton Research CentreRJ&AH Orthopaedic Hospital
4 Facilitating Biomedical Research ISTM brings together clinicians and bio-scientists across four hospital sites and the Keele campus:University Hospital of North Staffordshire, Hartshill, Stoke-on-TrentThe Haywood Hospital, Burslem, Stoke-on-TrentRobert Jones & Agnes Hunt Orthopaedic Hospital, OswestryLeighton Hospital, CreweSchool of MedicineSchool of PharmacySchool of Health & RehabilitationSchool of Life SciencesSchool of Computing & MathematicsSchool of Chemistry & PhysicsISTM Away Day 2014
5 Translational Research “bench to bedside”IndustrialPartnershipIndustrialPartnershipPotentialClinical applicationClinical TrialBasic scienceCell biology/ Physics/Biological ChemistryBioengineering/Imaging/In vitro/ In vivomodelling
6 ISTM - Current Staff 91 full members: Professors: 27Readers, Senior Lecturers, Clinical Lecturers: 40Lecturers: 18Research Fellows: 650+ NHS clinicians run clinical trials through ISTM27 affiliated members from other Keele RI’sKey chair appointments of senior clinical/non clinical academics to expand capacity~20 career-young researchers in the Schools ofMedicine, Pharmacy and SHAR
7 ISTM – Executive Committee Director Clinical Co-DirectorProf Alicia El Haj Prof Simon DaviesAssociate DirectorsDr Nicholas Forsyth (GHRC)Prof Anand Pandyan (Keele campus)Prof James Richardson (RJ&AH)Director of Postgraduate StudiesDr Paul Horrocks
8 ISTM – Scientific themes Resulting from 2013/14 reviews Bioengineering and Regenerative MedicineBiomagnetics and NanomedicineCell & Molecular MedicineDiagnostics, Engineering and ProteomicsHealth Services Research UnitNeuroscienceRehabilitationSustainable Pharmacy
9 Bioengineering & Regenerative Medicine Theme leader: Dr Nick ForsythBasic research into cell physiology and pathology, to developing new therapies in the laboratory, translating to treatments in the clinic and then assessing their efficacy by running clinical trials.European Centre of Excellence in Tissue Engineering.ARUK Centre of Excellence (+ Newcastle, Aberdeen, York)EPSRC Doctoral Training Centre in Regenerative Medicine (+ Loughborough and Nottingham)Part of 2 UK Regenerative Medicine Platform (UKRMP) hubs
10 Biomagnetics & Nanomedicine Theme leader: Dr Neil TellingNew nanomaterials, surface design and nano-particle formulations, both magnetic and polymer based, coupled to a benchmarking approach in the development of nano-magnetic technology for drug, gene and cell targeting.Peer reviewed grant support from EPSRC, BBSRC, MRC, RCUK, NIH (USA), Royal Society and European FP7European and US networks
11 Cell & Molecular Medicine Theme leader: Prof Gwyn WilliamsIncludes genetics and epigenetics, structural biology, cell biology, including apoptosis and the control of cell growth and a wide range of analytical techniques such as proteomics and electromagnetic imaging.Dedicated Human Genomics facility
12 Diagnostics, Engineering & Proteomics Theme leader: Dr Josep Sulé-SusoExpertise in structural biology, proteomics and synchrotron radiation with a key aim of establishing biomarkers for clinical applications.Selected Ion Flow Tube Mass Spectrometry (SIFT-MS)Microwave ImagingStructural Biology, leads UK Midlands consortiumProteomics facility
13 Health Service Research Unit Theme leader: Prof Simon Davies A joint initiative between Keele's Research Institutes for Science & Technology in Medicine, Primary Care Sciences and a range of NHS partners in North Staffordshire. To identify and promote beacon pathways of care as exemplars for integrating programmes of education, training, evaluation and applied health research with service development and high quality care.
14 Neuroscience Theme leader: Prof Divya Chari Specialises in several related basic, translational and clinical areas.Stem cell therapy and implantable materials for neurological disease and injuryMechanisms of brain development including plasticity mechanismsApplication of nanotechnology and nanoscale devices for neural repairDevelopment of reductionist models of neurological injuryGenetic studies and clinical trials in Multiple Sclerosis & stroke.
15 Rehabilitation Theme leader: Dr Ed Chadwick Uses science and engineering principles to tackle the physical limitations brought on by neuromuscular and skeletal disease, injury and ageing:Investigating biomechanical and physiological causesDeveloping Assistive devices to restore functionMathematical and conceptual models for biomedical and rehabilitation engineering research
16 Sustainable Pharmacy Theme leader: Dr David Morgan Addresses sustainable healthcare and pharmacy issues identified by “Improving the use of Medicines (for better outcomes and reduced waste)”. These priorities include:Involvement of patients in decisions about their treatment to help them use their medicines effectivelyReduction of the scale and cost of medicines wasteOptimisation of the supply and use of medicines, including optimisation in the synthesis and production of medicines.Reduction in the harm associated with medication use.Enhanced use of the Pharmacist in the community and in the developing healthcare setting.
17 ISTM - Activity Metrics Manages ~185 live research grants and trialsReceives £5m / year income, incl £3.8m in grantsApplies for ~150 new research grants / yearOutputs ~280 peer-reviewed publications / yearRAE2008: 90% of staff rated of international quality in UoA 25 General EngineeringREF2014: UoA 15 General EngineeringUoA 3 Allied Health ProfessionsUoA 5 Biological SciencesPotentially academics submitted
18 ISTM Current Major Funding Sources Keele QR funding is +1.5% for 2014/15
19 ISTM – Training Researchers Mentoring early-career lecturers and fellowsResearch fellows transition to independence~35 research assistants and technical staffSupport and activities: eg Keele studentships, start-up funds incl. MRC Centenary Awards, HEFCE Capital Equipment funds, workshops.
20 International links to ISTM Examples incl. China, Malaysia, Brazil, India, Saudi Arabia, Mali and Burkina FasoMasters and PhD / MPhil levelResearcher exchangesFunded programmes – eg MRC African Leaders grant, HYANJI SCAFFOLD, NEMO, MagNETicFUN, Fellowships
21 ISTM - Enterprise Activities Industrial collaborations, eg:Technology Strategy Board collaborative projectsMRC and BBSRC CASE studentships, primarily with UK companiesEuropean joint projects involving Small & Medium Sized EnterprisesContract research and clinical trials with UK / European industry, eg:3M Healthcare Abbott Laboratories AstraZeneca Biogen Bose Bristol Myers Squibb Cellon SA ConMed Cordis Endovascular GlaxoSmithKline GW Pharma Merck Sharp & Dohme Novartis Oxitec PepTcell Pfizer Smith & Nephew Surgicraft Syngenta Teva Weleda AG Wella AG Wyeth Research XenoGesis ZimmerLicensing of Intellectual PropertyExamples of current spin-off companies from ISTM:NanoTherics (www.nanotherics.com) Mica Biosystems (http://micabiosystems.com/)
22 Web pages and contacts: Director: Prof Alicia El Haj+44 (0)PA to Director: Joseph Clarke+44 (0)Facilities & Administration Manager: Jeanette Forrester+44 (0)RI Manager: Mark Smith+44 (0)