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Jennifer Siegel

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Statistical background Z-Test T-Test Anovas

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Science tries to predict the future Genuine effect? Attempt to strengthen predictions with stats Use P-Value to indicate our level of certainty that result = genuine effect on whole population (more on this later…)

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Develop an experimental hypothesis H0 = null hypothesis H1 = alternative hypothesis Statistically significant result P Value =.05

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Probability that observed result is true Level =.05 or 5% 95% certain our experimental effect is genuine

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Type 1 = false positive Type 2 = false negative P = 1 – Probability of Type 1 error

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Let’s pretend you came up with the following theory… Having a baby increases brain volume (associated with possible structural changes)

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Z - test T - test

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Population

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Cost Not able to include everyone Too time consuming Ethical right to privacy Realistically researchers can only do sample based studies

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T = differences between sample means / standard error of sample means Degrees of freedom = sample size - 1

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H0 = There is no difference in brain size before or after giving birth H1 = The brain is significantly smaller or significantly larger after giving birth (difference detected)

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T=(1271-1236)/(119-113)

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http://www.danielsoper.com/statcalc/calc08.aspx Women have a significantly larger brain after giving birth

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One-sample (sample vs. hypothesized mean) Independent groups (2 separate groups) Repeated measures (same group, different measure)

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ANalysis Of VAriance Factor = what is being compared (type of pregnancy) Levels = different elements of a factor (age of mother) F-Statistic Post hoc testing

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1 Way Anova 1 factor with more than 2 levels Factorial Anova More than 1 factor Mixed Design Anovas Some factors are independent, others are related

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There is a significant difference somewhere between groups NOT where the difference lies Finding exactly where the difference lies requires further statistical analysis = post hoc analysis

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Z-Tests for populations T-Tests for samples ANOVAS compare more than 2 groups in more complicated scenarios

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Varun V.Sethi

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Objective Correlation Linear Regression Take Home Points.

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Correlation - How much linear is the relationship of two variables? (descriptive) Regression - How good is a linear model to explain my data? (inferential)

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Correlation Correlation reflects the noisiness and direction of a linear relationship (top row), but not the slope of that relationship (middle), nor many aspects of nonlinear relationships (bottom).

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Strength and direction of the relationship between variables Scattergrams Y X YY X Y YY Positive correlationNegative correlationNo correlation

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Measures of Correlation 1)Covariance 2) Pearson Correlation Coefficient (r)

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1) Covariance -The covariance is a statistic representing the degree to which 2 variables vary together {Note that S x 2 = cov(x,x) }

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A statistic representing the degree to which 2 variables vary together Covariance formula cf. variance formula

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2) Pearson correlation coefficient (r) -r is a kind of ‘normalised’ (dimensionless) covariance -r takes values fom -1 (perfect negative correlation) to 1 (perfect positive correlation). r=0 means no correlation (S = st dev of sample)

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Limitations: Sensitive to extreme values Relationship not a prediction. Not Causality

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Regression: Prediction of one variable from knowledge of one or more other variables

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How good is a linear model (y=ax+b) to explain the relationship of two variables? - If there is such a relationship, we can ‘predict’ the value y for a given x. (25, 7.498)

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Linear dependence between 2 variables Two variables are linearly dependent when the increase of one variable is proportional to the increase of the other one xx yy Samples: - Energy needed to boil water - Money needed to buy coffeepots

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Fiting data to a straight line (o viceversa): Here, ŷ = ax + b – ŷ : predicted value of y – a: slope of regression line – b: intercept Residual error (ε i ): Difference between obtained and predicted values of y (i.e. y i - ŷ i ) Best fit line (values of b and a) is the one that minimises the sum of squared errors (SS error ) (y i - ŷ i ) 2 ε iε i ε i = residual = y i, observed = ŷ i, predicted ŷ = ax + b

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Adjusting the straight line to data: Minimise (y i - ŷ i ) 2, which is (y i -ax i +b) 2 Minimum SS error is at the bottom of the curve where the gradient is zero – and this can found with calculus Take partial derivatives of (y i -ax i -b) 2 respect parametres a and b and solve for 0 as simultaneous equations, giving: This can always be done

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We can calculate the regression line for any data, but how well does it fit the data? Total variance = predicted variance + error variance s y 2 = s ŷ 2 + s er 2 Also, it can be shown that r 2 is the proportion of the variance in y that is explained by our regression model r 2 = s ŷ 2 / s y 2 Insert r 2 s y 2 into s y 2 = s ŷ 2 + s er 2 and rearrange to get: s er 2 = s y 2 (1 – r 2 ) From this we can see that the greater the correlation the smaller the error variance, so the better our prediction

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Do we get a significantly better prediction of y from our regression equation than by just predicting the mean? F-statistic

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Prediction / Forecasting Quantify strength between y and Xj ( X1, X2, X3 )

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A General Linear Model is just any model that describes the data in terms of a straight line Linear regression is actually a form of the General Linear Model where the parameters are b, the slope of the line, and a, the intercept. y = bx + a +ε

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Multiple regression is used to determine the effect of a number of independent variables, x 1, x 2, x 3 etc., on a single dependent variable, y The different x variables are combined in a linear way and each has its own regression coefficient: y = b 0 + b 1 x 1 + b 2 x 2 +…..+ b n x n + ε The a parameters reflect the independent contribution of each independent variable, x, to the value of the dependent variable, y. i.e. the amount of variance in y that is accounted for by each x variable after all the other x variables have been accounted for

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Take Home Points - Correlated doesn’t mean related. e.g, any two variables increasing or decreasing over time would show a nice correlation: C0 2 air concentration in Antartica and lodging rental cost in London. Beware in longitudinal studies!!! - Relationship between two variables doesn’t mean causality (e.g leaves on the forest floor and hours of sun)

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Linear regression is a GLM that models the effect of one independent variable, x, on one dependent variable, y Multiple Regression models the effect of several independent variables, x 1, x 2 etc, on one dependent variable, y Both are types of General Linear Model

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Thank You

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