Presentation on theme: "Introduction to Medical Imaging Introduction to Medical Imaging MRI – Magnetic Resonance Imaging Guy Gilboa Course 046831."— Presentation transcript:
Introduction to Medical Imaging Introduction to Medical Imaging MRI – Magnetic Resonance Imaging Guy Gilboa Course 046831
MRI invention Several involved: ◦ Raymond Damadian – 1971, idea still very sketchy, no images produces. ◦ Paul Lauterbur – 1973-4, mature technique for 2D and 3D imaging. Produced first image of a living mouse. ◦ Peter Mansfield - developed a mathematical technique where scans take seconds rather than hours also producing clearer images. Nobel prize 2003, ◦ Paul Lauterbur ◦ Sir Peter Mansfield ◦ (Damadian left out, protests of him and colleagues). From top: Damadian, Lauterbur, Mansfield.
MRI scanner The lecture is based mainly on:  http://www.medphysics.wisc.edu/~block/bme_530_lectures.html  Ch. 5 of the book by N. B. Smith and A. Webb, Introduction to Medical Imaging, Cambridge University Press, 2011.
Typical brain MRI
MRI – basic operation principle The MRI is comprised of 3 main components: A superconducting primary magnet 3 magnetic field gradient coils RF transmitter and receiver Taken from https://wiki.engr.illinois.edu/display/BIOE414/Team+4+ -+MRI+Radio+Frequency+Coils https://wiki.engr.illinois.edu/display/BIOE414/Team+4+ -+MRI+Radio+Frequency+Coils
Movie – how MRI works (8.5 min.) https://www.youtube.com/watch?v=Ok9ILIYzmaY
Energy units V=volt; s=second; m=meter; J=joule; A=ampere; Wb=webber; N=newton; C=coulomb; g=gauss.
Magnetic Fields used in MR: 1) Static main field B o 2) Radio frequency (RF) field B 1 3) Gradient fields G x, G y, G z
Very strong magnets used in MRI Ohio Akron Children’s Hospital: 3T MRI (Magnetom Skyra, Siemens). Weight ~7,500kg. Cost $3.5M (2011).
Over 3T magnets very large and expensive 7T (Stanford) 9.4T (Siemens) http://news.stanford.edu/news/2005/may18/med-mri-051805.html http://www.siemens.com/press/en/pressrelease/?press=/en/pressrelease/2008/imaging_it/juelich.htm
Gradient coils Create a weak magnetic field in any direction in space. Magnetic field strength approximately 100 times lower than the main field.
Reference Frame z x y
Magnetic Moments MR is exhibited in atoms with odd # of protons or neutrons. Spin angular momentum creates a dipole magnetic moment Intuitively current, but nuclear spin operator in quantum mechanics Planck’s constant / 2 Model proton as a ring of current. Which atoms have this phenomenon? 1 H - abundant, largest signal 31 P 23 Na = gyromagnetic ratio : the ratio of the dipole moment to angular momentum
Energy states Hydrogen has two quantized currents, B o field creates 2 energy states for Hydrogen where Energy of Magnetic Moment in energy separation resonance frequency f o
Nuclei spin states There are two populations of nuclei: n + - called parallel n - - called anti parallel n+n+ n-n- lower energy higher energy Which state will nuclei tend to go to? For B= 1.0T Boltzman distribution: Slightly more will end up in the lower energy state. We call the net difference “aligned spins”. Only a net of 7 in 2*10 6 protons are aligned for H + at 1.0 Tesla. (consider 1 million +3 in parallel and 1 million -3 anti-parallel. But...
There is a lot of a water! 18 g of water is approximately 18 ml and has approximately 2 moles of hydrogen protons Consider the protons in 1mm x 1 mm x 1 mm cube. 2*6.62*10 23 *1/1000*1/18 = 7.73 x10 19 protons/mm 3 If we have 7 excesses protons per 2 million protons, we get.25 million billion protons per cubic millimeter!!!!
Torque – mechanical analogy Spins in a magnetic field are analogous to a spinning top in a gravitational field. (gravity - similar to B o ) Top precesses about Magnetic Torque
Precession rotates (precesses) about Precessional frequency: is known as the Larmor frequency. for 1 H 1 Tesla = 10 4 Gauss Usually, B o =.1 to 3 Tesla So, at 1 Tesla, f o = 42.57 MHz for 1 H or
Precession – Movie (7 min.) https://www.youtube.com/watch?v=7aRKAXD4dAg
RF Magnetic field The RF Magnetic Field, also known as the B 1 field To excite nuclei, apply rotating field at o in x-y plane. (transverse plane) B 1 radiofrequency field tuned to Larmor frequency and applied in transverse ( xy ) plane induces nutation (at Larmor frequency) of magnetization vector as it tips away from the z -axis. - lab frame of reference
RF general excitation (rotating frame) By design, In the rotating frame, the frame rotates about z axis at o radians/sec 1) B 1 applies torque on M 2) M rotates away from z. (screwdriver analogy) 3) Strength and duration of B 1 determines flip angle. This process is referred to as RF excitation. x y z
Coils diagram Simplified Drawing of Basic Instrumentation. Body lies on table encompassed by coils for static field B o, gradient fields (two of three shown), and radiofrequency field B 1. Image, caption: copyright Nishimura, Fig. 3.15
Detection - Switch RF coil to receive mode. Precession of M induces EMF in the RF coil. (Faraday’s Law) EMF time signal - Lab frame t Voltage (free induction decay) x y z M for 90 degree excitation
T1 and T2 relaxation times Application of RF pulse creates non- equilibrium state (adding energy to the system). After the pulse is switched off, the system is relaxed back to equilibrium. There are 2 relaxation times which govern the return to equilibrium: ◦ T1 (spin-lattice), equilibrium of z component. ◦ T2 (spin-spin), x and y components.
Tissue relaxation times for 1.5 Tesla Table: 5.1 from  TissueT 1 (ms)T 2 (ms) White matter79090 Gray matter920100 Liver50050 Skeletal muscle87060 Lipid (מסיס שומן)290160 Cartilage (סחוס)106042
Bloch Equation Solution: Longitudinal Magnetization Relaxation Component The greater the difference from equilibrium, the faster the change Solution: Initial Mz Doesn’t have to be 0! Return to Equilibrium
Transverse time constant T2 - spin-spin relaxation T 2 values: < 1 ms to 250 ms What is T 2 relaxation? - z component of field from neighboring dipoles affects the resonant frequencies. - spread in resonant frequency (dephasing) happens on the microscopic level. - low frequency fluctuations create frequency broadening. Image Contrast: Longer T2’s are brighter in T2-weighted imaging, darker in T1-weighted imaging
MR: Relaxation: Some sample tissue time constants - T 1 Image, caption: Nishimura, Fig. 4.2 fat liver kidney Approximate T 1 values as a function of B o white matter gray matter muscle
Gradient Fields - key for imaging - Paul Lauterbur Gradient coils are designed to create an additional B field that varies linearly across the scanner as shown below when current is driven into the coil. The slope of linear change is known as the gradient field and is directly proportional to the current driven into the coil. The value of B z varies in x linearly. z BzBz BoBo slope = G z Whole Body Scanners: |G| = 1-4 G/cm (10-40 mT/m) Gz can be considered as the magnitude of the gradient field, or as the current level being driven into the coil.
Basic Procedure 1)Selectively excite a slice ( z) - time?.4 ms to 4 ms - thickness?2 mm to 1 cm 2) Record FID, control G x and G y - time?1 ms to 50 ms 3) Wait for recovery - time?5 ms to 3s 4)Repeat for next measurement. - measurements?128 to 512 - in just 1 flip 5) Next: More on spatial encoding
Phase and frequency encoding It is not important which dimension encodes frequency and which phase. We assume: ◦ X encodes frequency ◦ Y encodes phase
K-space formalism (5.10)
Phase Direction Frequency Direction One line of k-space acquired per TR k-Space Acquisition Phase Encode DAQ Sampled Signal kxkx kyky Taken from 
Fast Fourier Transform FFT
8 x 8 512 x 512
16 x 16 512 x 512
32 x 32 512 x 512
64 x 64 512 x 512
128 x 128 512 x 512
256 x 256512 x 512
Signal Intensity and SNR
Multiple slice imaging The TR time required between successive RF excitations for each phase encoding step is much longer than TE. In this time other adjacent slices are usually acquired (maximum of TR/TE) Usually this is done in an interlacing fashion – od numbered slices are followed by even-numbered slices.
Spin-echo imaging sequence SS – Slice selection, PE – Phase encoding, FE – Frequency encoding, TR – Time of repetition, TE – Time of echo.
T1, T2, PD A long TR and short TE sequence is usually called Proton Density (PD) –weighted. A short TR and short TE sequence is usually called T1- weighted A long TR and long TE sequence is usually called T2-weighted Taken from http://www.imaios.com/en/e-Courses/e-MRI/MRI-signal-contrast/Signal-weighting
MR angiography Increase signal difference between flowing blood and tissue Based on TOF (time-of-flight) technique, shorter effective T1 due to flow if the slice is oriented perpendicular to the direction of flow.
Functional MRI Determines which areas of the brain are involved in cognitive tasks and brain functions such as speech and sensory motion. Based on the fact that MRI signal intensity changes depending upon the level of oxygenation of the blood in the brain (indicating increased neuronal activity). Uses fast scans which can cover the brain in a few seconds.
Example of fMRI Brain activity changes of teenagers playing violent video games. Taken from http://www2.rsna.org/timssnet/media/pressreleases/pr_target.cfm?ID=304 http://www2.rsna.org/timssnet/media/pressreleases/pr_target.cfm?ID=304
MR contrast agents Positive ◦ Paramagnetic contrast agents, shorten the T1 of tissue in which they accumulate. ◦ Based on gadolinium ion (Gd). ◦ Used to detect tumors, lesions in the central nervous system (brain and spine). Negative ◦ Superprparamgnetic (iron oxides), reduce T2 relaxation time. ◦ Used in detection of liver lesions.
Image characteristics (5.20)
Characteristics (cont’) Contrast to noise ◦ Contrast is based on T1, T2, PD scans. ◦ Can be manipulated by choices of TR, TE. ◦ For small lesions, the contrast is increased by having higher spatial resolution to minimize partial volume artifacts.
Examples – brain Comparison of PD, T1, T2 and angiography.
Cardiology 4 chamber view MR angiography of the chest (18 sec scan time)
Some clinical applications of MRI Used widely to scan almost every organ in the body, popular uses are: Neurological applications ◦ Can diagnose both acute and chronic neurological deseases. ◦ Method of choice for brain tumor detection. ◦ Most protocols involve administration of Gd. ◦ Many pathological conditions in the brain result in increased water content, which gives high signal intensity on T2-weighted sequences.
Clinical apps (cont’) Liver and Muscoloskeletal ◦ Can diagnose well lesions in fatty liver. Also iron overload, liver cysts, several lesions. ◦ Muscle-skeleton system. Knee scans to diagnose arthritis (joint inflammation). Cardiology ◦ To reduce motion artifacts - scans are gated according to the cardiac cycle, based on electrocardiograms (ECG). ◦ Detects myocardial infarcts, can measure left ventricular volume and ejection fraction. Good contrast between blood and myocardial wall. ◦ Diagnose coronary artery stenosis using angiography.
MRI vs CT – Brain image Better contrast in MRI for soft tissues, easy to distinguish between gray and white matter.
Comparison between MRI and CT CTMRI Ionizing radiationYesNo CostlowerHigher (x3?) Speed10-30 s (full scan 5- 10 min). Several minutes (full scan 30-60min) Data modesFewMany 3D imagesYes Resolution~7 lp/cm~3 lp/cm Work with metal in the body YesNo SNR increases asRadiation increases, or body is smaller. Primary magnet is stronger (also acquisition time)