Adrenaline acts by binding to a variety of adrenergic receptors. Adrenaline is a nonselective agonist of all adrenergic receptors, including the major subtypes α 1, α 2, β 1, β 2, and β 3.adrenergic receptorsagonistα 1α 2β 1β 2β 3 Increase cardiac output (β 1 receptors) Vasoconstriction ( ά 1 receptor)
β-receptor activation results in increased : 1. calcium influx in cardiac cells. 2. Premeblety of membrane to sodium
vagus nerve Ringer’s solution frog’s heart Dale’s Experiment 1. Stimulate the vagus nerve and the heart slows down 2. Add acetylcholine to the Ringer’s solution and the heart slows down
vagus nerve Ringer’s solution frog’s heart Loewe’s Experiment 1. Stimulate the vagus nerve and the heart in beaker A slows down THEN 2. Transfer Ringer’s solution from A to B and heart in B slows down A B transfer Ringer’s
Mechanism of Action Inhibits the actions of acetycholine on structures innervated by postganglionic sites (smooth/cardiac muscle, SA/AV nodes)
Digoxin: inhibit of Na/K ATPase pump K ion Ca ion
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